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Biomedical subjects

J Ivić

Publications and source records attributed to J Ivić.

15 recordsLinked to original sources
PubMed1979

Growth and treatment of Ehrlich tumor in mice with alloxan-induced diabetes.

Hypoglycemia and hypoinsulinemia accompanied i.p. or i.m. growth of the Ehrlich tumor in CBA/H and BALB/c mice. Simultaneously, insulin accumulated in the ascitic fluid of tumor-bearing mice. In hosts rendered diabetic by means of alloxan, the tumor decreased the blood glucose almost to the level seen in nondiabetic mice. Tumor growth was retarded in diabetic hosts, but cells from such tumors, transplanted into secondary diabetic recipients, grew faster than in their primary diabetic hosts, similarly to "nondiabetic" tumor cells growing in nondiabetic hosts. This phenomenon of "adaptation" of the tumor to the diabetic state was prevented if diabetic tumor-bearing mice were daily treated with insulin. The tumor did not grow in all diabetic recipients; the frequency of takes correlated with severity of the diabetes, i.e., with the dose of alloxan given to induce it. The greater the dose, the less mice accepted the tumor. Insulin injection into diabetic tumor-bearing mice promoted the tumor growth. Simultaneous treatment of diabetes and the tumor afforded the best antitumor effect.

Adaptation, Physiological↗
PubMed1979

[Menstrual cycle after artificial abortion].

In 84 women the establishment of the menstrual cycle after artificial abortion was observed by measuring basal temperature, examining the cervical mucus, and by cytologically analysing smears from the lateral vaginal fornix. Out of 3 women with the cycle up to 24 days before abortion, none had a cycle after abortion lasting less than 25 days. Of 31 women with the cycle exceeding 45 days before abortion, only 25 had such a long cycle after abortion. In the subsequent three cycles the menstruation appeared regularly, at the interval of 25--32 days, in 67 women. Before abortion such a cycle existed in 36 women. In most patients (56) the luteinic phase in the first cycle was shorter, it lasted 10 to 12 days.

Abortion, Induced↗
PubMedDate not supplied

[Significance of variations in the size of Trichomonas vaginalis in patients with dysplasia, intrapithelial and invasive planocellular carcinoma of the uterine cervix].

The study of the size of Trichomonas vaginalis in 100 patients with dysplasia and intraepithelial or invasive planocellular carcinoma of the uterine cervix and in 100 controls with trichomoniasis alone has shown that the parasites are of a significantly smaller diameter in carcinoma in situ (9.57 +/- 0.35 mu) and invasive carcinoma (10.44 +/- 0.66 mu) than in dysplasia (13.71 +/- 0.35 mu). The analysis of the variance has shown that this difference is statistically significant. In the control group with trichomoniasis alone, the diameter of Trichomonas vaginalis was twice as large (21.46 +/- 0.66 mu) as that in carcinoma and still larger than that in dysplasia. This indicates that small forms of Trichomonas vaginalis are more pathogenic than large ones and might be one of the causative agents of the atypical transformation of the squamous epithelium of the uterine cervix.

Carcinoma↗
PubMedDate not supplied

[Intraoperative cytodiagnosis of ovarian tumors].

The authors report on their experience in applying rapid intraoperative cytologic analysis in 83 benign and 54 malignant ovarian tumors of various pathohistologic types. The entire procedure, from the receiving of the material, fixing and staining, up to the cytologic diagnosis, did not last longer than 6 minutes. The cytologic findings were negative in all benign tumors except one (99.3%). In cases of malignant tumors the cytologic diagnosis was correct in 49 cases (96.4%). On the basis of cytomorphologic criteria it was also possible to predict the pathohistologic type of most of investigated tumors. The high overall accuracy rate of intraoperative cytologic examination permits the surgeon to make a quick and adequate therapeutic decision concerning the extent of intervention.

Adult↗