Primary evaluation of patients suspected of having interstitial cystitis (IC).
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Cystitis, Interstitial↗
Biomedical subjects
J J Bade
Publications and source records attributed to J J Bade.
A placebo-controlled study of intravesical pentosanpolysulphate for the treatment of interstitial cystitis.
OBJECTIVE: To evaluate the therapeutic efficacy of intravesical pentosanpolysulphate (PPS) compared with placebo in patients with interstitial cystitis (IC). PATIENTS AND METHODS: Twenty patients who fulfilled the diagnostic criteria for IC participated in a double-blind placebo-controlled study; 10 received intravesical PPS (300 mg in 50 mL of 0.9% sodium chloride) applied twice a week for 3 months and the other 10 received a placebo. Symptomatic relief and objective variables (bladder capacity voiding volumes and urinary frequency) were assessed after 3 months and the long-term outcome of those continuing treatment was determined. RESULTS: Of the patients treated with PPS, four gained significant symptomatic relief compared with only two receiving placebo. Only the urodynamic bladder capacity showed a statistically significant increase in patients treated with PPS (P = 0.047). At 18 months from the start of the study, the symptoms were relieved in eight patients while still receiving PPS instillations and in four without treatment. CONCLUSIONS: These results suggest that intravesical PPS is an effective option for the treatment of IC and shows that the intravesical application of PPS is a safe treatment with no important side-effects.
Administration, Intravesical↗
Is the diet of patients with interstitial cystitis related to their disease?
OBJECTIVE: The dietary habits of interstitial cystitis (IC) patients compared to the average food and fluid consumption of the general population were evaluated and any spontaneous preference or avoidance of specific foodstuffs and fluids of IC patients was investigated. METHODS: A verbal interview with 16 IC patients provided information on the consumption of foodstuffs and fluids as well as dietary habits. Prior to the dietary interview none of the IC patients were aware of any possible dietary measures in relation to their IC symptoms. The results were compared to the averages of the general population. RESULTS: IC patients consumed statistically significantly less calories and fat (p < 0.05), and statistically significantly more fibers (p < 0.01) than the general population. Among the IC patients there were significantly fewer consumers of coffee (p < 0.01) and significantly more consumers of (herbal) tea (p < 0.05). The difference in orange juice consumption was not significant. CONCLUSIONS: According to general standards, IC patients had a more healthy daily diet than the general population. The observation that IC patients consumed less coffee (caffeine) than the general population is consistent with previous reports on irritative IC symptoms exacerbating after caffeine consumption. No rationale for other dietary or fluid intake changes was found.
Adult↗
Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.
PURPOSE: We investigated the role of Tamm-Horsfall protein in interstitial cystitis. MATERIALS AND METHODS: Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein. RESULTS: Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases. CONCLUSIONS: The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.
Adult↗
Interstitial cystitis in The Netherlands: prevalence, diagnostic criteria and therapeutic preferences.
PURPOSE: We determine the prevalence of interstitial cystitis in The Netherlands, and analyze the most common diagnostic and therapeutic approaches among Dutch urologists. MATERIALS AND METHODS: A questionnaire was completed by urologists and analyzed with the help of a statistical computer program. RESULTS: The prevalence of interstitial cystitis was calculated to be 8 to 16/100,000 female patients. Pathology of bladder biopsies and the presence of mast cells were the main diagnostic criteria. Dimethyl sulfoxide instillations, bladder hydrodistension and surgery were the most frequently applied therapies. CONCLUSIONS: The prevalence of interstitial cystitis in The Netherlands is in line with that of other reports from Europe but low compared to the United States findings. The importance of pathology and the presence of mast cells in the diagnosis, as well as less awareness might contribute to this difference.
Cystitis, Interstitial↗
Intravesical treatment of interstitial cystitis with a heparin analogue.
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Administration, Intravesical↗
A pelvic mass: bladder diverticulum with haemorrhage in Ehlers-Danlos patient.
We report on a case of haemorrhage in a large bladder diverticulum, impressing as a pelvic mass, in a patient with the Ehlers-Danlos syndrome. A review of the literature revealed 14 other cases of bladder diverticula and the Ehlers-Danlos Syndrome. Conservative treatment is first choice, unless complications occur.
Adult↗
The Hartmann procedure, five years' experience.
During a 5-year period (1985-1990) a Hartmann procedure was performed in 66 patients. Retrospective analysis was done to analyse circumstances influencing mortality, restoration of bowel continuity, prognostic value of per-operative peritonitis and results of open wound treatment. Thirteen patients (19.6%) died post-operatively. Colorectal continuity was subsequently restored in 27 patients of 44 potential candidates (61%). Peroperative purulent or faecal peritonitis and acute diverticulitis was found to significantly influence (p < 0.05) the mortality rate. Resection below the sigmoid level gave a significant lower frequency of reanastomosis. Open wound treatment in selected patients proved to be effective: only two (3.0%) cases of wound infection were seen in 66 patients.
Adolescent↗