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Biomedical subjects

J J Barboriak

Publications and source records attributed to J J Barboriak.

At least 55 records · Page 3Linked to original sources
PubMed1984

Correlation of the extent of coronary occlusion with Apo B levels. Application of a new enzyme immunoassay technique for Apo B.

A new rapid and sensitive method for measurement of apolipoprotein B (Apo B) in plasma has been developed. This method, based on a Competitive Enzyme-Linked Immunoassay (CELIA), has been used to study the association between the extent of coronary artery occlusion as measured by coronary arteriography and the levels of plasma Apo B. The correlation between Apo B levels and some other plasma lipids was also determined. Significant relationship was found between the extent of coronary artery occlusion and Apo B, as well as between Apo B and plasma total cholesterol and plasma triglyceride levels.

Adult↗
PubMed1983

Examination of a competitive enzyme-linked immunoassay (CELIA) technique and a laser nephelometric immunoassay technique for the measurement of apolipoprotein B.

A competitive enzyme-linked immunoassay (CELIA) technique for quantitative measurement of apolipoprotein B (Apo B) was developed. The method is a non-isotopic immunoassay that utilizes a soluble enzyme/antibody complex as a universal labeling reagent. The method was characterized according to precision, sensitivity, recovery and parallelism. The CELIA Apo B method was compared to a commercially available laser nephelometric immunoassay. We found that the nephelometric results were highly correlated with triglyceride levels and the nephelometric assay was susceptible to interference from lipemia or turbidity. The range of values obtained on 56 apparently healthy, fasting young adults was 0.35-1.25 g/l by the CELIA method and 0.40-1.00 g/l by the nephelometric immunoassay. The nephelometric method was more precise (coefficient of variation 5%) than the CELIA technique (CV 10%); however, the CELIA method seems to be less sensitive to interferences.

Adult↗
PubMed1983

Improvement in heart disease risk factors after gastric bypass.

Fasting blood levels of three lipid classes (high-density lipoprotein-cholesterol [HDL-C], total cholesterol, and triglycerides) were measured in morbidly obese patients before, and six and 12 months after, Roux-en-Y gastric bypass. Weight above ideal in 31 women averaged 72 kg, and in 12 men, 78 kg. Excess weight lost after six months was 49.7%. Total cholesterol levels and abnormally high triglyceride levels (183 +/- 106 mg/dL [SD]) decreased and became normal after six months. Low-normal HDL-C levels in 31 women (45 +/- 13 mg/dL) improved by six months to 54 +/- 19 mg/dL; similarly, HDL-C levels in 12 men (38 +/- 9 mg/dL) increased to 57 +/- 17 mg/dL. One of eight diabetic patients remained hyperglycemic; ten of 15 patients who were hypertensive, requiring medication preoperatively, became normotensive by six months. Lipid levels measured again at one year showed little change. Risk factors of coronary heart disease were improved by gastric bypass in these morbidly obese patients, and the changes were clearly established by six months after operation.

Adult↗
PubMed1983

The relationship between vasectomy and angiographically determined atherosclerosis in men.

Long-term prospective studies in monkeys have shown that vasectomy is associated with an increase in atherosclerotic disease. The purpose of the present investigation is to evaluate whether vasectomy in men is associated with atherosclerotic disease in the coronary arteries. In this study information was obtained on the vasectomy status in a series of 7,420 men who had previously been referred for coronary angiography because of cardiovascular symptomatology and have been followed for as long as 9 years to evaluate coronary artery bypass surgery and the natural history of the disease. It was found that 5.0% had a vasectomy prior to angiography. Two different data analysis procedures were used to determine whether the vasectomized men had a greater degree of angiographically determined coronary occlusive disease than the nonvasectomized men. Subgroups with minimal and extensive coronary artery disease were also analyzed. Results of all analyses show that the vasectomized men did not have more coronary occlusive disease. Possible patient selection biases in this study are discussed.

Adult↗
PubMed1983

Nutrition in spinal cord injury patients.

The nutrient intake and some indices of nutritional state were studied in 22 quadriplegic and 15 paraplegic patients. When measured over two 5-day periods, the average caloric intake recommended for comparable healthy men (2,700 kcal/day) was not achieved by 75% of the quadriplegic and 47% of the paraplegic patients. No overt signs of malnutrition or vitamin deficiencies were observed, but the average hematocrit and serum albumin levels were at the lower limits of normal. The reduced energy needs of spinal cord patients should be considered in the development of desirable nutritional norms for this patient population.

Adult↗
PubMed1983

Alcohol consumption and the diet-heart controversy.

The effectiveness of dietary changes as a means of reducing blood lipid levels and ultimately controlling the development of coronary heart disease has been debated for many years. The possible effects of alcohol consumption on blood lipids were usually not considered. Our findings indicate a significant positive correlation between the extent of coronary artery occlusion and total plasma cholesterol levels and a negative association between the coronary occlusion and high density lipoprotein (HDL) cholesterol. Since moderate alcohol consumption increases the HDL cholesterol levels, one can also postulate that it affects coronary artery lesions. The attenuating effect of alcohol on the coronary occlusion was negated by sporadic drinking of large amounts of alcohol. In evaluating the possible effect of alcohol on coronary artery disease, it is also necessary to consider its addictive potential as well as other untoward sequelae of alcohol consumption such as hypertension, damage to the myocardium, and increased prevalence of malignancies.

Alcohol Drinking↗
PubMed1982

Association between plasma high density lipoprotein cholesterol and antipyrine metabolism in alcoholics.

Seven patients entering an alcoholic detoxification and treatment unit exhibited elevated levels of plasma high density lipoprotein cholesterol (HDLC) and enhanced metabolic disposal of antipyrine. Following a 2-week abstinence treatment, the HDLC levels were reduced by 28% (from 64 to 47 mg/100 ml) and the t 1/2 of antipyrine was extended from 12.4 to 13.7 hours. The extent of the HDLC reduction correlated with the antipyrine t 1/2 changes (r = -0.753, P = 0.05).

Adult↗
PubMed1982

Risk factors and late recurrence of angina following myocardial revascularization.

To assess the influence of risk factors on the recurrence of angina several years after myocardial revascularization, 316 patients were studied. We report that 249 patients obtained relief of angina from coronary bypass surgery and remained free of angina up to 4 years later. The remaining 67 patients experienced initial relief of angina 1 year following bypass surgery and then, subsequently, redeveloped angina 4 years postsurgery. There was no statistical difference in any risk factor between patients who remained free of angina after myocardial revascularization and those who developed angina. Of the total 316 patients, 79% were free of angina 4 years after coronary bypass surgery.

Adult↗
PubMed1982

Smoking, alcohol and coronary artery occlusion.

The effects of smoking and alcohol intake on the extent of coronary artery occlusion were studied in 2989 men undergoing a diagnostic coronary arteriography. Smoking showed an exposure-related enhancing effect on the extent of coronary artery occlusion. Conversely, alcohol consumption demonstrated an attenuating dose-related effect, offsetting the increased coronary occlusion associated with smoking. Alcohol intake should be considered in studies evaluating the risk factors--coronary artery disease interaction.

Alcohol Drinking↗
PubMed1982

Effects of drinking patterns on the relationship between alcohol an coronary occlusion.

Previous reports have described an inverse relationship between alcohol consumption and the prevalence of myocardial infarction or the extent of coronary artery occlusion. The study reported here explored the relationship between patterns of alcohol intake and coronary occlusion in 526 patients who have had coronary arteriography. Patients were characterized as regular drinkers, occasional drinkers and non-drinkers. Regular drinkers were further characterized as drinking relatively consistent amounts or variable amounts. The inverse correlation between amounts of alcohol consumed and coronary occlusion found in previous studies was reaffirmed. It was also observed that the pattern of alcohol intake was related to the degree of occlusion. Higher levels of occlusion were found among non-drinkers, occasional drinkers, and regular drinkers with patterns of variable intake, while significantly lower levels of occlusion were observed for regular drinkers who drank relatively consistent amounts (P = 0.014). Furthermore, while occlusion scores were inversely correlated with amounts consumed by regular drinkers with consistent intake (P = 0.019), drinkers with variable drinking patterns had higher occlusion scores regardless of amounts consumed. Analyses of serum lipids according to drinking patterns showed a significant association between the total/HDL cholesterol ratio and drinking patterns. These findings suggest that whatever attenuating effect alcohol consumption might exert on coronary occlusion, it appears to be reversed by a variable or sporadic pattern of alcohol intake.

Adult↗
PubMed1982

Effect of cold exposure on thyroid hormone in Fischer 344 rats of increasing age.

Male rats aged 6 weeks, 6 months, and 18 months were kept at 4 to 5 degrees C for 12 days and compared with age-matched controls at room temperature as to survival, weight change, food consumption, core body temperature, and several parameters of thyroid hormone economy. After 12 days in the cold, 14%, 50%, and 71% of 6-week-, 6-month-, and 18-month-old rats, respectively, were living. Weight declined in both older groups, though at a faster rate in the oldest. Increasing age did not affect serum T3, rT3, TSH, or the ability to convert T4 to T3 by 20% liver homogenate. Cold exposure, however, resulted in an increase in serum T3 and a decrease in T4 to T3 conversion by liver homogenate in a similar magnitude both in mature and early senescent rats.

Adaptation, Physiological↗
PubMed1982

Blood pressure and alcohol intake in heart patients.

The association between alcohol consumption and blood pressure has been studied in 2025 male and 282 female patients undergoing diagnostic coronary angiography. The increase in amount of alcohol consumed correlated with higher systolic and diastolic blood pressure; this effect was especially pronounced in men over 50 years of age. The association was less marked in male patients under 50 years old, in women, and in patients on antihypertensive medication. Readings in the range of definitive hypertension were more prevalent among older patients consuming six or more drinks daily than in abstainers of the same age group.

Adult↗
PubMed1982

Reliability of a brief scale for assessment of coronary-prone behavior and standard measures of type A behavior.

45 male volunteers were classified by the Structured Interview for Type A behavior and also by the Jenkins Activity Survey. Each subject also responded to a series of 10 questions taken from the Milwaukee Cardiovascular Life Quality Questionnaire. 10 items of the questionnaire were tested to form a scale, the Milwaukee questionnaire--10 for the classification of Type A and B coronary-prone behavior. Each response was rated as one if it was in the previously defined direction of Type A or as zero if in Type B direction. The mean response in this population was 3.56. Subjects scoring 0 to 3 were then classified as Type B and those scoring 4 and more as Type A. Subjects were also given two standard measures of Type A behavior, the Jenkins survey and the structured interview. Comparisons of Type A vs B classes were made between the Milwaukee questionnaire and the interview and the Jenkins survey. High agreement rating Type A behavior was found among instruments. The 10 items appear to provide a reliable and brief scale for rating Type A coronary-prone behavior.

Adolescent↗
PubMed1981

Smoking, coronary artery occlusion, and nonfatal myocardial infarction.

The association of smoking with a history of myocardial infarction (MI) was studied in 3,997 men who had coronary arteriography. The patients were subdivided into groups based on coronary occlusion (minimal, moderate, or severe) and plasma cholesterol level (low, moderate, or high). For men older than 50 years, smoking was significantly associated with MI in each occlusion group. For men younger that 50 years, the association was significant for men with moderate or severe occlusion. In the presence of higher cholesterol levels there was a stronger association of smoking with MI, but weaker association association of smoking with coronary occlusion. These results suggest that the association of smoking with MI does not depend primarily on the atherogenic effect of smoking. The association seems to be enhanced by high levels of coronary occlusion and cholesterol.

Adult↗
PubMed1981

Abstinence-induced changes in plasma apolipoprotein levels of alcoholics.

Plasma lipids, including total cholesterol, plasma triglycerides, high density lipoprotein cholesterol and several apolipoproteins were measured in eight otherwise healthy male alcoholics at the beginning and during a 4-week inpatient abstinence treatment program. The initial triglyceride and apolipoprotein A-11 levels were higher and apolipoprotein B was lower in alcoholics than in 12 nondrinking control subjects. During the alcohol abstinence there was a parallel fall in the levels of high density lipoprotein cholesterol, and apolipoproteins A-I and A-II and a rise in apolipoprotein B. The changes in apolipoproteins C-III and E were less consistent. These findings suggest that, even in otherwise healthy alcoholics, elevated levels of apolipoproteins A-I and A-II on admission are ameliorated during abstinence of several weeks.

Adult↗