[Nitrates and tolerance].
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Delayed-Action Preparations↗
Biomedical subjects
J J Bonnier
Publications and source records attributed to J J Bonnier.
Systemic effects of BRL 26921 during thrombolytic treatment of acute myocardial infarction.
The effects of BRL 26921, an active-site acylated streptokinase-plasminogen complex, on the fibrinolytic and coagulation systems were studied in 13 patients treated for acute myocardial infarction with a short intravenous infusion of 30 mg of the new drug. In 12/13 patients (92%) significant changes were observed in the concentrations of fibrinogen, fibrin(ogen) degradation products, plasminogen, alpha 2-antiplasmin and F VIII:C; all changes indicating a substantial degree of systemic fibrinolysis. In only one patient were no signs of systemic activation of the fibrinolytic system observed. The therapeutic efficacy of the drug was 85% in this study.
Adult↗
Improved success rate of percutaneous transluminal graft and coronary angioplasty with the El Gamal guiding catheter.
In the period between October 1980 and December 1982 we evaluated the outcome of percutaneous transluminal graft and coronary angioplasty when a Judkins type guiding catheter (J gc) was initially used, but the lesion could not be passed and a subsequent attempt was made with the El Gamal guiding catheter (EG gc). Seven of twelve attempts to dilate stenotic coronary artery bypass grafts failed. The EC gc was tried in six, five were successfully dilated; one failed. Our initial attempts to dilate a stenosed right coronary artery failed in 16 of 68 attempts. The EG gc was attempted in 14. We successfully dilated ten, two dissections required emergency coronary artery bypass grafting (CABG); two failed. Our initial attempts to dilate a left anterior descending artery stenosis failed in 14 of 109 attempts. Six lesions were passed when the EG gc was tried. Five were successfully dilated, and one acute dissection required emergency CABG; eight failed. The EG gc is useful for transluminal angioplasty of stenosed aortocoronary bypass grafts. It increased the success rate of right coronary artery dilatation from 76-91%, but was of limited use in dilatation of left anterior descending lesions.
Angioplasty, Balloon↗
Modeling of (coronary) laser-angioplasty.
A first attempt to describe (coronary) laser angioplasty is presented using simplified but standard optical and thermal modeling of tissue in interaction with a laser. Ablation behavior of blood thrombi and plaque has been approximated from numerical computations for various wavelengths representing the Ar, Nd-YAG, and CO2 lasers. The overall results, in terms of calculated depth of ablation versus laser irradiation time, show a relatively fast initial process followed by a very slow one. The analysis suggests that a sequence of laser pulse-catheter tip flushing should substantially increase the overall ablation velocity. The physics of threshold laser power and influence of laser beam diameter is discussed. A comparison between experimental results is made when possible. Suggestions for further test experiments are made.
Coronary Disease↗
Optical properties of human blood vessel wall and plaque.
Optical properties of blood vessel wall and plaque from human cadaver material are presented for the argon laser (514.5 nm), He-Ne laser (633 nm), and the Nd-YAG laser (1,060 nm) wavelengths. Measurements were performed with an integrating sphere arrangement and analyzed in terms of Kubelka-Munk absorption and scattering coefficients.
Arteriosclerosis↗
Balloon inflation caused by contrast injection through the guiding catheter: an unusual observation during coronary angioplasty.
Balloon inflation caused by contrast injection through the guiding catheter has been observed during several angioplasty procedures. The phenomenon is observed when employing an 8F USCI guiding catheter in combination with an ACS dilatation catheter. Two cases demonstrating the phenomenon are described in detail, together with an in vitro experiment that illustrates and quantifies the mechanism.
Aged↗