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Biomedical subjects

J J Buneaux

Publications and source records attributed to J J Buneaux.

At least 19 recordsLinked to original sources
PubMed1978

[Zinc and enzymes in the synovial fluid and blood in various types of rheumatism].

It appears that in rheumatoid arthritis and, to a lesser extent, in the other forms of inflammatory rheumatism, the level of zinc in the blood serum is lowered, whereas synovial zinc is increased. In the synovial fluid, there is a very significant correlation between enzyme activity and the concentration of zinc. Practical experiments aimed at demonstrating in vitro the action of zinc on lacticodeshydrogenase, acid phosphatase, lysozyme and beta-glucuronidase did not produce the anticipated results and do not explain the metabolic disorders of zinc seen during inflammatory rheumatisms.

Acid Phosphatase↗
PubMed1977

[Automated measurement of elastase activity and elastase inhibitory capacity of serum].

A technic of autoanalysis of the elastase activity and the capacity of elastase inhibition of the serum is described. This estimation depends on the hydrolysis by elastase of N-ter-butoxycarbonyl-L-nitrophenyl ester with liberates p.nitrophenol the colour of which is read at 405 nm. The means of this sample estimation are reported in a few cases of respiratory, dermatological and pancreatic disease.

Animals↗
PubMed1977

[The effect of osmic acid on synovial and serum beta-glucuronidase activity].

The authors report that osmic acid, in vitro, increases the activity of beta-glucuronidase in serum and synovial, ascitic and pleural fluids, whereas five other metals of similar molecular weight (platinum, gold, mercury, thallium and lead) are either inactive or inhibitory. By contrast the osmium diminishes the activity of LDH and acid phosphatases in serum and synovial fluid. This effect on beta-glucuronidase is thought to be due to inhibition of a natural inhibitor present in biological fluids, a protein found by several authors.

Acid Phosphatase↗
PubMed1976

[New research on synovial enzymology].

After reviewing previous work on the subjects, the authors show that the synovial fluid in subjects with inflammatory rheumatism contained higher levels of lysozyme and of beta-glucuronidase comparable with those of the acid phosphatases and of lacto-dehydrogenase that they were interested in previously.

Acid Phosphatase↗
PubMed1976

[Complete alpha-1-antitrypsin deficiency in a patient with Ehlers-Danlos syndrome].

Complete alpha-1-antitrypsin deficiency of the type PiOO associated with chronic obstructive lung disease, cutaneous hyperextensibility and hyperlaxity of joints were found in a nineteen-year-old Moroccan boy. On a nosological point of view, this patient could be included as a 8th form, in the Ehlers-Danlos syndrome which now groups seven clinical variants. A causal relationship between the biological deficiency and the clinical alterations (pulmonary, cutaneous and articular) could be assumed according to the biological and ultrastructural findings.

Adult↗
PubMed1975

[Several synovial enzymes in rheumatoid arthritis].

The authors show that although the enzyme variations are nil or unimportant in the mechanical joint fluids, they are of some importance in the inflammation fluids, particularly in cases of rheumatoid arthritis. Of those studied so far, the variations are most notable in the dehydrogenases and the phosphatases, the variations being highly significant and related to one another and to the sedimentation rate.

Acid Phosphatase↗
PubMed1975

Study of glucagon secretion using in vitro perifusion of rat pancreas pieces.

The in vitro perifusion technique of rat pancreatic tissue has been studied in respect of sensitivity and reproducibility regarding alpha-2-cell function. Convenient and quickly performed, it allows the kinetic analysis of humoral factors of glucagon release when the blood vessels are too small to be cannulated, for instance in case of fetal pancreas and of tumor tissue. A2 cells in the perifused pancreatic tissue release glucagon in response to arginine, norepinephrine and the decrease of glucose concentration in the medium. The sensitivity of this preparation is lower than that of the perfused pancreas: this may be related to unphysiological conditions of fluid circulation, of the degradation of the stimuli and degradation of the hormone released. Satisfactory conditions of perifusion flow rate and amount of panceatic tissue have been defined and several protective agents have been tested.

Acetylcholine↗