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Biomedical subjects

J J Daly

Publications and source records attributed to J J Daly.

At least 55 records · Page 3Linked to original sources
PubMed1979

Intravesical thio-tepa: a study of 3H-thymidine uptake in normal urothelium and FANFT-induced tumors in rats.

Treatment of superficial low-grade bladder cancer often incorporates intravesical instillations of the alkylating agent thio-TEPA. Current dosages and administration schedules are empiric inasmuch as cytokinetic data are sparse. The FANFT-induced bladder rat tumor model closely approximates human bladder cancer. This study measuring 3H-thymidine uptake identified peaks of maximal synthetic activity at 3 and 9 days after thio-TEPA exposure in both normal and neoplastic urothelium. Thus, repeat instillation at these intervals may improve cytotoxicity and overall response rate.

Animals↗
PubMed1978

The effect of intravesical thio-tepa on normal and tumor urothelium.

Intravesical thio-tepa instillations for 55 patients with superficial transitional cell carcinoma were evaluated prospectively in the treatment of residual disease (therapeutic) and the prevention of recurrence (prophylactic). The over-all response rate to therapeutic thio-tepa was 56 per cent, with toxicity observed in 26 per cent of the cases. Patients with microscopic residual tumor showed better response and less toxicity than those with gross residual tumor. Prophylactic thio-tepa had no effect in lowering recurrence rates. Examination of pre-treatment and post-treatment biopsies showed no worsening of atypia and no correlation between improvement in atypia and gross tumor response. A charcteristic post-treatment thio-tepa effect was observed in non-tumorous urothelium but not in tumor biopsies. The differentiation of such thio-tepa effect cells from pre-malignant atypical cells is discussed.

Carcinoma, Transitional Cell↗
PubMed1978

Altered androgen metabolism in metastatic prostate cancer.

Admixture of androgen-sensitive elements from normal or hyperplastic prostatic tissue interferes with biochemical studies of prostate cancer in its primary site. Heterogeneity of cancer tissues, varying in stromal and epithelial elements, also complicates interpretation of data relating to androgen metabolism. Accordingly, we have compared metastatic deposits composed of epithelial cancer cells to the primary biopsies of 4 patients in respect to uptake of 3H-testosterone and its conversion to 5-alpha-dihydrotestosterone during in vitro incubation. 3H-testosterone uptake was similar for both tissue sites but 3H-dihydrotestosterone formation was reduced by 76% in the metastases compared to primary tissues. This group was not large enough to show statistical significance, whereas a total of 11 such primary studies compared to 6 metastatic specimens was significant. When either primary or secondary tissue results were compared to 12 cases of benign prostatic hyperplasia similarly studied the differences were highly significant. These results demonstrate a major impairment in the formation of dihydrotestosterone by metastatic prostatic cancer and a similar but less evident alteration in the primary site. This abnormality in testosterone metabolism is of major importance in the attempt to obtain effective hormonal control of human prostatic cancer.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1978

Free-living fungi as artifacts on hematology preparations.

The appearance of Helicosporium sp., a free-living fungus, is reported as a contaminant resembling nematode microfilaria on a Wright's stained blood smear. Also, an unidentified object with structures resembling the septate hyphae of the Fungi Imperfecti and two other forms with some features similar to the fungal genus Fusarium were found on leukocyte alkaline phosphatase preparations of blood smears. The possible incorrect identification of these pseudoparasites is discussed and a review of the pertinent literature included.

Hematologic Tests↗
PubMed1978

In vivo growth of human bladder cancer cell lines.

Two human bladder cancer cell lines grew predictably in rats immunosuppressed with antilymphocyte serum. Intraperitoneal inoculation of tumor cell suspensions resulted in diffuse intraabdominal carcinomatosis with consequent host death after 10 to 20 days. Subcutaneous inoculation of tumor cell suspensions resulted in local tumors which grew exponentially for 20 to 30 days before eventual regression after 40 to 50 days; lung metastases developed in at least 13 per cent of the animals with subcutaneous tumors. The histologic appearance of the xenografted tumors closely resembled that of the original tumors. Subsequent in vitro culture of the xenografted tumors provided cell lines that were morphologically identical to the primary lines and that retained a human karyotype. It is proposed to employ this model of human bladder cancer to evaluate chemotherapeutic agents for possible use in the clinical disease.

Animals↗
PubMed1977

Exertion-induced rhabdomyolysis with acute renal failure and disseminated intravascular coagulation in sickle cell trait.

From 1970 to 1974, among thousands of trainees seen at two large military installations who were subjected to the same physical and environmental stresses, only four recruits were hospitalized because of acute exertional rhabdomyolysis, renal failure and coagulopathy. The illness followed the performance of vigorous exercise. These four patients had sickle cell trait. In an attempt to explain this association, the data in these four cases are summarized. The hypothesis is then developed that rhabdomyolysis and endothelial damage, terminating in severe coagulopathy, may more likely occur in patients with sickle cell trait who are subjected to virorous physical exertion.

Acute Kidney Injury↗
PubMed1977

Prognosis of clinically undiagnosed prostatic carcinoma and the influence of endocrine therapy.

A 10-year series of 100 patients with clinically undiagnosed prostatic adenocarcinoma is presented. In 50 per cent of these patients the tumor was well differentiated and the survival was normal, while the remainder of the patients had moderately to poorly differentiated tumors and survival rates significantly less than normal. Of 8 deaths caused by cancer 7 were associated with less-than-well differentiated tumor. Patients who received endocrine therapy and died of causes other than cancer had a significantly shorter interval to death and a higher incidence of cardiovascular deaths than those who were untreated. While the majority of patients with incidental, clinically undiagnosed prostatic carcinoma is not at risk from the disease a minority exists who may benefit from radical therapy.

Adenocarcinoma↗
PubMed1977

Positive urinary cytology in patients without evident tumor.

Of 267 patients with a positive urinary cytology during a 5-year period 9 did not have a tumor identified at the initial diagnostic stidy, which included cytoscopy. However, a tumor was documented in 8 of these 9 patients between 1 and 61 months later.

Biopsy↗
PubMed1977

Evidence against gastrointestinal pseudoparasitism by the land planarian, Bipalium kewense Moseley 1878.

The possibility of gastrointestinal pseudoparasitism by the free-living land planarian, Bipalium kewense, was tested by feeding and survival experiments. The intestinal tracts of three dogs were negative for B. kewense after the individual dogs were fed eight, three, and four large worms and autopsied at 12 h, 3 h, and 45 min, respectively. Survival of the worms in Warburg flasks, under N2, AT 27 C, was 2 h or less.. In Gas Pak jars (CO2 + H2) at 37 C, survival was less than 60 min. Aerobically, at 37 C, survival varied from 45 to 60 min. Attra-tion of the worms to stool material was examined by placing planaria inside square whose boundries were constructed of fecal smears. Bipalium kewense exposed to canine feces showed strong avoidance reactions. Urea, a nitrogen end product of these worms, was also shown to be a negative stimulus for B. kewense. Failure to establish even short term passage in the digestive tract, lethality of 37 C and anaerobic environments, and sensitivity to feces makes gastrointestinal pseudoparasitism unlikely in these organisms.

Anaerobiosis↗
PubMed1977

Venomous animals and their victims: a program for sophomore medical students.

As Americans increase their outdoor activities, the possibility of contact with venomous animals becomes greater. At the University of Arkansas for Medical Sciences a program has been developed for sophomore medical students to help meet this potential health threat. Lectures are given on the recognition and general biology of dangerous reptiles and anthropods, the nature of animal venoms, immunological aspects of envenomation, and the treatment of bites and stings. Both first-aid and clinical management are included. Laboratory demonstrations consist of both live and preserved specimens of venomous animals. Live specimens of reptiles, as well as informed curators, are provided by the Little Rock Zoological Gardens in what may be a unique cooperative effort between a medical school and a zoo. The program has been judged to be a success on the basis of the response of the medical students.

Animals↗
PubMed1976

The liver in hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease).

The livers of four patients with hereditary hemorrhagic telangiectasia--including the original case of Osler--were examined at autopsy. Characteristic random focal fibrovascular lesions were found in all. The importance of recognizing the apparently common and seemingly benign hepatic involvement in this disease is emphasized in view of its possible confusion with more serious types of liver disease that may complicate the condition.

Aged↗
PubMed1976

Endocrine changes after diethylstilbestrol therapy. Effects on prostatic neoplasm and pituitary-gonadal axis.

This study was undertaken to determine the effects of DES (diethylstilbestrol) on prostatic neoplasms and of different dosage levels on the pituitary-gonadal axis. It is recommended that when DES is chosen for treatment plasma testosterone be monitored carefully and for long periods of time to evaluate the ability of the dose to achieve levels comparable to castration in each patient.

Diethylstilbestrol↗
PubMed1976

Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ.

We evaluated 129 patients with low grade, low stage transitional cell carcinoma of the bladder with a minimum followup of 5 years. In addition to the phenomena recognized as indicators of a serious clinical problem (grade greater than I, rapid recurrence, multiple tumors and lamina propria invasion) the identification of carcinoma in situ and/or atypia in normal, incidentally resected mucosa adjacent to the tumor was found to be a positive predictor for subsequent muscle invasion. Ten of 12 patients with carcinoma in situ and 9 of 25 patients with atypia were among 39 who experienced invasion.

Adult↗