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J J Dizon

Publications and source records attributed to J J Dizon.

15 recordsLinked to original sources
PubMed1967

Studies on cholera carriers.

Cholera carrier studies in the Philippines in 1964-66 showed a prevalence rate of 21.7% among household contacts of cholera patients, and 8.4% in occupants of houses next door to one where a cholera patient lived, as opposed to 0.34% in the general population. The duration of the carrier state among 19 household carriers isolated for examination varied from 5 to 19 days. The vibrio concentration in the stool of contact carriers was 10(2)-15(5) per gram, as compared with 10(6)-19(9) per ml of rice-water stool in cholera cases.The agglutinin titre increased with time for carriers, as it does for patients. It declined to a very low level 8-12 weeks after recovery, with the exception of one proved long-term carrier.The strains isolated from carriers were identical in all respects, including virulence in infant rabbits, with strains isolated from patients-except that 3 carrier strains were rough.

Adolescent↗
PubMed1967

A long-term carrier of cholera: cholera Dolores.

The first known long-term carrier of cholera, found in the Philippines, is described. The carrier, Dolores M., who had suffered from El Tor cholera in August 1962, continued intermittently to excrete vibrios of the same characteristics as the original isolates until the date of reporting (1966). Duodenal intubation proved that the vibrios are lodged in her biliary tract. Her serum antibody titre continued to remain high in the absence of vaccination against cholera.

Biliary Tract↗
PubMed1965

Studies of cholera El Tor in the Philippines. I. Characteristics of cholera El Tor in Negros Occidental Province, November 1961 to September 1962.

After freedom from cholera for over a quarter of a century, the Philippines in 1961 experienced an epidemic of cholera. The disease, shown to be caused by the El Tor strain of cholera vibrio, was clinically indistinguishable from classical Asian cholera. Studies were undertaken in Negros Occidental Province from August to October 1962 to characterize various aspects of the epidemics in this province. This paper describes the general characteristics of the epidemics in Negros Occidental from November 1961 through September 1962.Two types of epidemic occurred. The first, explosive in nature, suggested a common source of spread of infection; the second, with a more protracted course, seemed to be due to person-to-person spread of disease. In the second epidemic, a single hospitalized case in a household and a single hospitalized case in a community were the most common findings, suggesting that infection did not spread easily or, if easily spread, caused significant disease on rare occasions only.

Adolescent↗
PubMed1965

Studies of cholera El Tor in the Philippines. 2. A retrospective investigation of an explosive outbreak in Bacolod City and Talisay, November 1961.

The introduction of cholera into many of the islands of the Philippines in 1961 often occurred in an explosive manner. The disease was introduced into Bacolod City and Talisay in Negros Occidental Province in such a manner in November 1961. The authors describe the results of an analysis of hospital and health department records in Bacolod City and Talisay and the results of interviews conducted with adult patients 10 months after the explosive outbreak.The results suggest that infection during the initial explosive wave of cases in Bacolod City and Talisay in November 1961 was transmitted principally by shrimp that were consumed raw.

Adolescent↗
PubMed1965

Studies of cholera El Tor in the Philippines. 3. Transmission of infection among household contacts of cholera patients.

As part of a broad epidemiological investigation of cholera El Tor in the Philippines, the authors cultured rectal swabs obtained from the household contacts of cholera patients hospitalized in the Negros Occidental Provincial Hospital from August through October 1962. Additional infected persons were found in 25 (60%) of the 42 households with confirmed cases and in 55 (18%) of 302 household contacts of confirmed patients. Since only five of the 55 infected household contacts developed illness severe enough to require hospitalization, it was apparent that those with severe illness accounted for but a small proportion of the total infections. Asymptomatic infections were rarely found outside the households with proven cases, suggesting that close person-to-person contact was necessary for the spread of infection. Asymptomatic carriers as well as symptomatic patients appeared to play significant roles in the transmission of infection.

Adolescent↗
PubMed1965

Studies of cholera El Tor in the Philippines. 4. Transmission of infection among neighbourhood and community contacts of cholera patients.

As part of a broad study on the epidemiology of cholera El Tor in the Philippines, the authors conducted bacteriological surveys among the community contacts of suspect cholera patients hospitalized in the Negros Occidental Provincial Hospital from August through October 1962. Fourteen (2%) of 698 community contacts of persons with confirmed cholera patients were found on initial culture to be infected.Intensive studies in two communities suggested that infection was spread primarily by close personal contact; in a third community, contamined well-water presumably served as a vehicle for the transmission of infection. Diagnosed and undiagnosed cases, undiagnosed cholera deaths and asymptomatic infections all played a role in cholera transmission.The studies tend to confirm that the second or recurrent epidemic in Negros Occidental was primarily caused by person-to-person spread. Although the seemingly isolated or sporadic cases were sometimes associated with a more general distribution of the cholera vibrio, the cholera infections invariably were highly localized among close contacts even within densely populated areas with poor sanitation.

Adult↗