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Biomedical subjects

J J Doeven

Publications and source records attributed to J J Doeven.

6 recordsLinked to original sources
PubMed1977

Lobular carcinoma of the breast.

Lobular carcinoma of the breast, both the in situ and the infiltrating type, is discussed on the basis of three observations. Mammography may be useful, although if often leads to the diagnosis of mastopathy. In cases of in situ lobular carcinoma, ablation of the breast constitutes an adequate therapy. The adequacy of subcutaneous removal of the mammary parenchyma is doubtful. In infiltrating lobular carcinoma, radical mastectomy by Halsted's or Patey's method is the treatment of choice. In view of the frequent bilaterality of the condition, an ample elective biopsy of the identical quadrant of the contralateral breast should be performed in every case.

Adult↗
PubMed1975

Penile cancer.

A retrospective study was made of the case histories of 91 patients with a penile tumor. The tumor histology of 56 patients could be re-evaluated, confirming the diagnosis: epidermoid cancer. Fifty three of these 56 patients were treated more than five years before the retrospective evaluation. Penile carcinoma has not increased in frequency during the last few decades. No correlation could be found between venereal diseases and penile carcinoma, nor between the duration of symptoms before treatment and the development of metastases. Amputation is the treatment of choice. Lymph node dissection must be performed when metastatic disease is suspected. When patients die of tumor, this is caused by metastatic disease, but in about 50 percent of cases the patients can be saved by dissection of positive nodes, preventing a further extension. More than 70 percent of 53 patients have survived for at least five years without evidence of recurrence or metastatic disease including six (out of 11) patients in whom the dissected inguinal lymph nodes showed involvement. In this series of patients cytostatic therapy was not used. Bleomycin is known to have a definite action on these tumors, but only the far future can show if better results are to be expected with a combination of the described therapy with cytostatic drugs.

Adult↗
PubMed1975

Results of treatment of incisional hernias with extractable prostheses.

A series of 80 patients with an incisional ventral hernia were treated with an extractable prosthesis in the period 1 January 1965--1 January 1974. The results are discussed. After a description of the advantages of an extractable prosthesis, attention is given to a number of factors which are possibly of importance in the development of such a hernia. This is most probably a multifactorial process, in which suturing technique, wound infection, obesity and postoperative rise of intra-abdominal pressure may play a part. The technique of inserting the extractable prosthesis is accurately described and illustrated with drawings and photographs. Success was ultimately obtained in 86.25% of the cases. The failure rate was 13.75%. In comparison with the data from the literature, this is a low percentage, the more so because the author's series consisted mainly of large incisional hernias. Recurrences can be treated successfully several times with an extractable prosthesis. This is, in general, easy in view of the smaller dimensions of the hernial orifices. The extractable prosthesis is recommended both for the treatment and prevention of incisional ventral hernia.

Abdominal Muscles↗
PubMed1975

A case of embryonal sarcoma (rhabdomyosarcoma) of the prostate treated with combined surgical and cytostatic therapy.

The case history of a 22-months old boy with a malignant embryonal tumor of the prostate is given. Five years after initiation and three years after termination of a combined therapy with cytostatic drugs (actinomycin D, vincristine sulfate and cyclophosphamide) and surgery he is in good health without any signs of recurrence or metastatic disease. On this moment it is still impossible to be certain whether this therapy is the key for treatment of these tumors, but the successes published and the result till now in this case can be an indication that we are going in the right direction. Perhaps we may even hope that in the future we will have cytostatic drugs and combinations of therapy which will enable us to avoid mutilating operations.

Child, Preschool↗