Biomedical subjects
J J Ellis
Publications and source records attributed to J J Ellis.
A multidisciplinary approach to the evaluation and treatment of temporomandibular joint and cervical spine dysfunction.
This article presents a multidisciplinary approach to the management of temporomandibular joint (TMJ) and cervical spine dysfunction in a heterogeneous population of patients. A methodology for the systematic evaluation and treatment of patients is outlined; case histories are used to illustrate the workings of the model. A study to assess the efficacy of treatment was performed on 27 female and three male adult patients. Results indicated that patients achieved an 87% recovery rate at discharge with an 83% success rate six months after discharge. A control study was undertaken using 16 female and three male adults to establish indications for TMJ occlusal splint therapy in patients who present with questionable TM dysfunction. The multidisciplinary model presented in this article provides a system of patient evaluation and treatment that can be easily adopted by clinicians involved in a team approach to TMJ and cervical spine dysfunction.
Psychotherapy with physicians' families: when attributes in medical practice become liabilities in family life.
Personality attributes typically found in successful physicians can lead to difficulties in family life. This paper identifies physicians' positive characteristics and demonstrates with case-history material how these characteristics can contribute to interactional problems with family members. Ways of engaging physicians in treatment and avoiding some of the common pitfalls in working with this group are discussed.
Production of deoxynivalenol and zearalenone by isolates of Fusarium graminearum Schw.
The production of deoxynivalenol (DONI) on rice, corn, wheat, and barley grains by Fusarium graminearum Schw. NRRL 5883 was investigated. Highest yields (91.9-202 ppm) were obtained on rice; yields on the other substrates were: corn (34.1-84.5 ppm), wheat (3.6-24.4 ppm), and barley (0-6.6 ppm). Fifty isolates of Fusarium from corn inoculated in the field in 1979 with a mixture of strains of F. graminearum, originally collected from corn plants infected with stalk rot, were tested for DONI production on corn. Twenty of these were also tested for zearalenone production. One isolate produced more than 200 ppm DONI, 13 produced 20-50 ppm, 17 produced 10-20 ppm, and the rest produced less than 10 ppm. The only isolate that did not produce DONI was not identified as F. graminearum. All 20 isolates tested produced zearalenone; 18 produced higher levels of zearalenone (15.4-369 ppm) than of DONI. The other 2 isolates formed essentially the same levels of zearalenone and DONI-37 and 30 ppm, and 15 and 16 ppm, respectively.
Group therapy with anorexic and bulimic patients: implications for therapeutic intervention.
The incidence of anorexia nervosa and bulimia has increased markedly during the last decade. Although numerous studies have appeared regarding the dynamics of the eating-disordered patient, few have attempted to link the unique pathology of these patients to specific psychotherapeutic interventions. This paper is based on the authors' experience as co-therapists with a group of eating-disordered patients over an eight months' period. It addresses itself to therapeutic interventions related to the particular dynamics of bulimics and anorexics.
Computed tomography of bowel perforation.
The authors present 2 cases of intestinal perforation which were not associated with free intraperitoneal air detectable on abdominal radiographs. Computed tomography demonstrated evidence of intraperitoneal leakage of orally administered contrast material and thereby provided the correct diagnosis.
Abnormal accumulation of technetium-99m hepatobiliary agent in a case of idiopathic bile peritonitis.
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Feed refusal in cattle associated with Fusarium moniliforme in corn.
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Production of vomitoxin on corn by Fusarium graminearum NRRL 5883 and Fusarium roseum NRRL 6101.
Two vomitoxin-producing isolates of Fusarium spp. were grown on cracked corn for 1 to 8 weeks at 15, 20, 25, 28, and 32 degrees C. Maximum production of vomitoxin by Fusarium graminearum Schw. NRRL 5883 occurred at 30 degrees C and 40 days, and that by Fusarium roseum Schw. NRRL 6101 occurred at 26 degrees C and 41 days. These optimum production points were determined from response surface contour graphs in relation to temperature and time. Only small amounts of vomitoxin were produced at 15 and 20 degrees C by each strain. A 133-microgram quantity of vomitoxin, with an indicated purity of 95%, was isolated per gram of corn fermented with F. graminearum NRRL 5883.
Experimental cerebral zygomycosis in alloxan-diabetic rabbits: variation in virulence among zygomycetes.
We investigated the potential of 33 different zygomycete isolates to cause cerebral disease following the intranasal instillation of their spores into ketotic rabbits with alloxan induced diabetes. The isolates represented six thermotolerant species of Rhizopus (R. arrhizus, R. chinensis, R. microsporus, R. oligosporus, R. oryzae, and R. rhizopodiformis), Absidia corymbifera, Cunninghamella bertholletiae, and Rhizomucor pusillus. All 13 isolates of the thermotolerant Rhizopus species proved to be cerebral pathogens as confirmed by culture and histopathology. One isolate of R. oligosporus and one isolate of R. rhizopodiformis, however, were less pathogenic than isolates of other Rhizopus species tested. Cerebral pathogenicity was noted with 2 of 5 isolates of Rh. pusillus and only 1 of 13 A. corymbifera isolates. Two thermotolerant C. bertholletiae cultures, recovered from human lesions, did not cause either cerebral or pulmonary disease in ketotic rabbits. The incidence of pulmonary zygomycosis caused by the isolates of the species of the four genera under study was as follows: Rhizomucor 24%, Rhizopus 22%, Absidia 9%, and Cunninghamella 0%. This study confirms the pathogenic potential of the thermotolerant species of Rhizopus to cause cerebral zygomycosis in ketotic diabetic rabbits and also revealed the potential of Rh. pusillus and A. corymbifera occasionally to cause the same disease in animals and humans.
Swine refusal factors elaborated by Fusarium strains and identified as trichothecenes.
Fusarium poae (Peck) Wollenw. NRRL 3287, F. nivale (Fr.) Ces. NRRL 3289, and F. moniliforme Sheldon NRRL 3197, each grown on cracked corn (13 days at 28 degrees C), produced refusal factors in pig bioassays. Substantial quantities of trichothecenes were detected in the refused corn: T-2 toxin (30 micrograms/g) was detected in corn fermented with the F. poae strain; the level of vomitoxin (1 microgram/g) in corn cultured with F. nivale did not account for the 48% refusal response in the pigs tested. The F. moniliforme concomitantly produced T-2 toxin (33 micrograms/g) and vomitoxin (1.5 micrograms/g). This strain's taxonomic position was reexamined, and it is shown to be a cultural variant of the species F. tricinctum (Cda.) Sacc.
Elaboration of vomitoxin and zearalenone by Fusarium isolates and the biological activity of Fusarium-produced toxins.
Sixteen Fusarium isolates belonging to F. graminearium Schw. and F. culmorum (W.G. Smith) Sacc. produced vomitoxin and zearalenone on cracked corn at 28 degrees C. Quantitation for vomitoxin was by gas-liquid chromatography. This toxin was produced in quantities of 5 to 236 microgram/g of fermented corn. Vomitoxin showed weak antibiotic activity against Penicillium digitatum Sacc., Mucor ramannianus Möller, and Saccharomyces bayanus Sacc., but did not inhibit gram-positive, gram-negative, or acid fast bacteria. The two molds and the yeast were inhibited by T-2 toxin at 5 micrograms, and diacetoxyscirpenol inhibited the molds at 5 micrograms and the yeast at 50 micrograms.
Antibiotic-producing fungi: current status of nomenclature.
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Toxic effects of a butenolide mycotoxin and of Fusarium tricinctum cultures in cattle.
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Studies of the toxicity of Helminthosporium maydis.
Isolates of Helminthosporium maydis from blighted corn were tested for toxicity in mice, rats, swine, rabbits, microorganisms, and tissue culture. Extracts of grains, mycelia, and culture supernatant fluids killed mice on intraperitoneal (ip) injection, but were nontoxic on administration by mouth to swine. The toxin was partially purified and appears to be a glycophospholipid. Histopathological examination revealed that the toxin acted as a severe irritant on ip injection, causing death in laboratory animals. In skin tests with rabbits, considerable exudation occurred, rather than necrosis.
Survey for fusaria that elaborate T-2 toxin.
Of the 136 strains of Fusarium examined, T-2 toxin was confirmed by thinlayer chromatography in 13 of the 21 extracts that inhibited either Rhodotorula rubra or Pencillium digitatum.
Correlation of biological to chromatographic data for two mycotoxins elaborated by Fusarium.
Thirty-seven identified strains of Fusarium, most of them isolated from fescue grass, were tested for their ability to elaborate mycotoxins in laboratory culture. The presence of the toxins was determined by infrared light, thin-layer chromatography, mouse toxicity, fungistatic effects, and phytotoxic properties. A good correlation was demonstrated between T-2 toxin detection by thin-layer chromatography and inhibition of Rhodotorula rubra by culture extracts. All of the strains producing either butenolide or T-2 toxin were toxic to mice with but one exception; those producing T-2 toxin inhibited growth of the yeast.