PubMed Health⌕ Search

Biomedical subjects

J J FRANKS

Publications and source records attributed to J J FRANKS.

12 recordsLinked to original sources
PubMed1963

Calculation of the albumin catabolic rate in the non-steady state.

Methods which are in current use for the calculation of the albumin breakdown rate apply only to the steady state animal. In this paper a simple but more general method based on analyses of I(131)-albumin tracer data is presented. It utilizes easily measured plasma specific activity and excretory data and is equally applicable to the steady and non-steady states.

Albumins↗
PubMed1963

The role of the gut in albumin catabolism. I. Studies in the jejunoileectomized rabbit.

I(131)-albumin metabolic studies were carried out in 5 rabbits before, 3 weeks after, and several months after removal of 70 to 90 per cent of the jejunum and ileum. A sixth animal was studied before and 11 weeks after a sham operation. During postoperative experiments, the animals were found to be in a highly unsteady state with large losses of albumin from the vascular compartment. Despite these losses, the plasma albumin concentration was maintained at a relatively constant level. No decrease in the albumin efflux occurred following nearly complete jejuno-ileectomy. The data suggest that albumin catabolism is a first order process.

Albumins↗
PubMed1963

The role of the gut in albumin catabolism. II. Studies in enterectomized rabbits.

Using I(131)-albumin tracer methods, albumin breakdown rates were estimated in 7 rabbits following extensive gastrointestinal resection, including 5 with nearly complete enterectomy, 1 with total gastroenterectomy, and 1 with gastrectomy only, and in 4 sham operated rabbits. Breakdown rates in the resected animals varied from 48 to 187 per cent of the corresponding controls, with an average of 96 per cent. It is concluded that no more than one-half, and probably much less, of albumin breakdown occurs in the gastrointestinal tract.

Albumins↗