PubMed Health⌕ Search

Biomedical subjects

J J Fath

Publications and source records attributed to J J Fath.

22 records · Page 2Linked to original sources
PubMed1984

Metabolism during hepatic transplantation: indicators of allograft function.

In an attempt to determine the initial function of hepatic allografts, several metabolic indicators of hepatic function were studied intraoperatively in 12 cases of hepatic transplantation. The operation was divided into three sampling periods: baseline, anhepatic, and reperfusion. During the baseline period plasma lactate levels rose at 2.6 mmol/L/hr and continued to rise at a similar rate during the anhepatic period. Baseline period total free plasma amino acid levels (TFPAA) rose at a moderate rate of 0.4 mmol/L/hr. During the anhepatic period TFPAA levels rose at a fivefold greater rate than during baseline (p less than 0.01). The ability of the hepatic allograft to reduce abnormal levels of TFPAA and lactate during the reperfusion period was associated with reduced morbidity in the first 48 hours after transplantation. Intraoperative clearance of accumulated TFPAA is currently the best means of assessing initial allograft function. Elevated preoperative total serum bilirubin levels were also associated with increased early morbidity in hepatic transplant recipients.

Adult↗
PubMedDate not supplied

Antibiotics for penetrating abdominal trauma: a prospective comparative trial of single agent cephalosporin therapy versus combination therapy.

In this prospective, comparative study, 129 patients who sustained penetrating abdominal trauma were randomized to receive preoperatively, and for 3-5 days postoperatively, one of three antibiotic regimens: Group I--cefotaxime (CTX) (2 Gm Q8H), Group II--cefoxitin (2 Gm Q6H), or Group III--clindamycin (900 mg Q8H) and gentamicin (3-5 mg/kg/day in divided doses Q8H). The three groups were similar in terms of the following: age, sex, severity of injury, number of organs injured, colon injuries, shock, blood transfusions, or positive intraoperative cultures. Septic complications occurred as follows: Group I--6.9%, Group II--2.3%, and Group III--6.9%. The three regimens ranked as follows in terms of therapy costs: CTX less than cefoxitin less than clindamycin and gentamicin. It is concluded that single agent therapy with a cephalosporin is preferable to combination therapy on the basis of equivalent effectiveness, lower toxicity, and lower costs.

Adult↗
PubMedDate not supplied

Amino acid abnormalities in infants with extrahepatic biliary atresia and cirrhosis.

We measured fasting plasma amino acids in 26 children aged 6 months to 5 years with extrahepatic biliary atresia and cirrhosis and compared them with fasting values in 95 normal control children aged 4 months to 12 years. We found that the cirrhotic children had elevations of total free plasma amino acids implying reduced hepatic metabolism of amino acids and that the molar ratio of the branched chain amino acids (isoleucine, leucine, and valine) to the aromatic amino acids (phenylalanine and tyrosine) was significantly depressed. Methionine was also markedly elevated, and taurine concentrations were significantly decreased. Manipulation of the amino acid distribution in dietary protein to normalize plasma amino acids prior to orthotopic hepatic transplantation may be helpful in improving amino acid utilization.

Amino Acids↗