PubMed Health⌕ Search

Biomedical subjects

J J Ferguson

Publications and source records attributed to J J Ferguson.

143 records · Page 8Linked to original sources
PubMed1986

Systolic, diastolic, and combined hypertension. Differences between groups.

We used a classification system of systolic, diastolic, and combined (both systolic and diastolic) hypertension to ascertain whether there were significant differences between the groups. The study involved 182 consecutive outpatients for whom no secondary cause of hypertension could be found. There were 96 male and 86 female patients, with a mean age of 45.8 years. There were significant differences in age, with the systolic group being the oldest and the diastolic group the youngest. There were also differences in the prevalence of complications among the categories. Peripheral vascular disease, retinopathy, and coronary artery disease were more prevalent in the systolic and combined groups, while diabetes was more prevalent in the systolic group. We conclude that there appear to be clinical differences between systolic, diastolic, and combined hypertension with respect to presenting characteristics and complications.

Adolescent↗
PubMed1985

The relationships of high energy phosphates, tissue pH, and regional blood flow to diastolic distensibility in the ischemic dog myocardium.

Myocardial ischemia due to increased oxygen demand (pacing tachycardia plus critical coronary stenoses) alters diastolic distensibility and relaxation more than ischemia of comparable duration due to coronary occlusion. To investigate the relationship between myocardial diastolic function and metabolism, we compared myocardial high energy phosphate content, tissue pH, and regional blood flow for these two types of ischemia in anesthetized open-chest dogs. Myocardial biopsies were done with a high-speed air-turbine biopsy drill, permitting rapid (less than 1-second) freezing of tissue samples from both nonischemic and ischemic areas, while myocardial pH was measured with a hydrogen ion-selective polymer membrane implanted in the subendocardium. After 3 minutes of pacing tachycardia in dogs with critical coronary stenoses (demand-type ischemia, n = 14), regional systolic function (% segment shortening by ultrasonic crystals) was mildly depressed (from 19 +/- 2% control to 13 +/- 2% post-pacing, P less than 0.01), while left ventricular diastolic pressure-segment length relations shifted upward, indicating decreased distensibility of the ischemic myocardial segment. Associated with these changes in function, subendocardial adenosine triphosphate decreased (from 31.3 +/- 1.5 to 27.9 +/- 1.0 nmol/mg protein, P less than 0.01), as did creatine phosphate (53.8 +/- 2.1 to 39.6 +/- 2.5 nmol/mg protein, P less than 0.01), while myocardial pH declined slightly (delta pH = -0.14 +/- 0.02, P less than 0.01). In contrast, at 3 minutes of coronary artery occlusion (primary ischemia, n = 14), regional segment shortening was replaced by systolic bulging (% shortening decreased from 17 +/- 2% to -2 +/- 1% during occlusion, P less than 0.01), while left ventricular pressure-segment length relations were not shifted upward, and there was no decrease in diastolic distensibility of the ischemic segment. With coronary artery occlusion, subendocardial adenosine triphosphate declined slightly (33.2 +/- 0.5 to 29.2 +/- 2.0 nmol/mg, P less than 0.05), while creatine phosphate decreased substantially (51.1 +/- 2.3 to 7.8 +/- 1.4 nmol/mg protein, P less than 0.01). Myocardial pH fell strikingly (delta pH = -0.33 +/- 0.03, P less than 0.01), and the decline was 236% of that seen with demand-type ischemia. Regional myocardial blood flow (microsphere technique) showed a decreased endocardial:epicardial (endo:epi) ratio (1.04 +/- 0.04 control vs. 0.40 +/- 0.05 during pacing, P less than 0.01) and absolute subendocardial flow (1.02 +/- 0.47 to 0.47 +/- 0.05 ml/min per g, P less than 0.01) with demand-type ischemia.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1984

Stroke volume--pulse pressure relationships in borderline hypertension: a possible indicator of decreased arterial compliance.

Resting invasive haemodynamic measurements were performed on 354 volunteers, 168 normals, and 186 with borderline hypertension. To test the hypothesis that patients with borderline hypertension would have a decrease in the compliance of their arterial system, the relationship of stroke volume (SV) and stroke volume index (SVI) to pulse pressure (PP) in the two groups was examined. Theoretically, as compliance decreases, there should have been a stronger relationship between SV or SVI and PP. In the sample studied, SV and SVI were significantly related to PP in borderline hypertensive patients (P less than 0.005), but not in normotensive patients. When the samples were divided into tertiles of low, middle, and high SV, the borderline hypertensive patients had higher PP with higher SV (P less than 0.01), while the normals did not. It is concluded that there appear to be significant differences between normals and patients with borderline hypertension in the relationship of SV and SVI to PP. This can be interpreted as evidence to support the existence of an abnormality in arterial compliance in borderline hypertension.

Adult↗
PubMedDate not supplied

Abrupt vascular closure.

Explore the source record for details and available documents.

Angioplasty, Balloon, Coronary↗
PubMedDate not supplied

The relation of clinical outcome to dissection and thrombus formation during coronary angioplasty. Heparin Registry Investigators.

BACKGROUND: Although the development of thrombus or dissection during percutaneous transluminal coronary angioplasty (PTCA) increases the risk of abrupt vessel closure, the magnitude of the effect is difficult to define. OBJECTIVE: The aim of the study was to determine prospectively the effect of the development of thrombus or dissection on PTCA procedural outcome. METHODS: Data from 591 consecutive angioplasty procedures involving 756 lesions at 9 clinical centers were included in a prospective registry with a core angiographic laboratory. RESULTS: Clinical success (defined as < 50% stenosis of all target lesions assessed in a core angiographic laboratory, with no major complications of death, Q wave or non-Q wave myocardial infarction or emergency CABG) was achieved in 497 patients (84%). Major complications occurred in 45 (7.6%). Abrupt vessel closure, including both established closure (TIMI grade 0 or I flow) and impending closure (> 50% stenosis, TIMI grade 0-2 flow, plus use of additional interventions) occurred in 65 patients (11%). Angiographically visible dissections developed in 40% of lesions; more severe grades of dissection were associated with reduced success rates, and increased incidence of and abrupt vessel closure and major complication. Angiographic evidence of thrombus (filling defects) developed in 12.3% of lesions; the presence of thrombus was associated with significantly lower procedural success (61% vs. 86%) and significantly higher rates of abrupt vessel closure (28% vs 7%) and major complications (24% vs. 6%). With multivariable analysis, thrombus was identified as an independent predictor of procedural success, abrupt vessel closure, and major complications. CONCLUSIONS: The development of severe dissections or thrombus following PTCA is associated with significantly lower procedural success rates and higher rates of abrupt vessel closure and major complications. Patients who develop severe dissection or thrombus may be appropriate candidates for more aggressive forms of therapy.

Adult↗