Biomedical subjects
Publications and source records attributed to J J Gallo.
Care of the elderly patient with dementing illness involves not only the patient but also the family and other caregivers, and the community. An evaluation and treatment plan must go beyond the patient's immediate medical problems to examine the caregiver's needs and the community services available.
Caregivers play a critical role in providing the social support that allows impaired elders to remain at home. The demands of caregiving, however, may stretch the physical and psychological resources of the caregiver, thus jeopardizing the elder. The social support available to the caregiver may help buffer or mitigate the ill effects of caregiving. The purpose of this review is to examine the effect of social support on the development of depression in the caregiver, with a consideration of the components and measurement of social support. The practical as well as the research implications are discussed. Although the anticipated difficulty of caregiving depends on assessment of the elder's mental and functional disability as well, the clinician must not neglect to consider the caregiver's appraisal of the social support available. This assessment need not be elaborate and might include inquiring (1) whether the caregiver has someone in whom to confide; (2) who visits the caregiver, how often, and whether the caregiver is happy with these relationships; (3) what aspects of caregiving are most disturbing; and (4) whether there are symptoms of depression.
Many theories have been proposed to explain aging. Currently, the most important theories include genetic control, deterioration of the immune system, somatic mutation, accumulated damage by free radicals, cross-linkage of macromolecules, and metabolic causes. While no single theory accounts for all of the observations about aging, recent research suggests that the primary process is under genetic control, with contributions from environmental factors.
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Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.
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