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Biomedical subjects

J J Grimshaw

Publications and source records attributed to J J Grimshaw.

At least 19 recordsLinked to original sources
PubMed1989

Benzoyl peroxide in the treatment of acne vulgaris: a double-blind, multi-centre comparative study of 'Quinoderm' cream and 'Quinoderm' cream with hydrocortisone versus their base vehicle alone and a benzoyl peroxide only gel preparation.

A double-blind, multi-centre general practice study was carried out to compare the effectiveness of benzoyl peroxide/potassium hydroxyquinoline sulphate cream, with or without hydrocortisone, its aqueous astringent cream base alone, and a benzoyl peroxide alcoholic gel in the treatment of 107 patients with acne vulgaris. Patients on entry were allocated at random to one of four treatment groups and instructed to apply the medication twice daily to all affected areas for 12 weeks. Assessments of the severity of acne on the face, chest and back, and response to treatment were made at 2, 4, 8 and 12 weeks. Acceptability of the treatment, i.e. 'greasiness', was also assessed by patients. The results showed that the combination cream preparation produced a greater reduction in acne scores than did the base or benzoyl peroxide alone. The addition of 1% hydrocortisone eliminated the flare reaction to benzoyl peroxide seen in patients in the other two active treatment groups. The majority of patients found the preparations cosmetically acceptable.

Acne Vulgaris↗
PubMed1986

A clinical trial of hydrocortisone/potassium hydroxyquinoline sulphate ('Quinocort') in the treatment of infected eczema and impetigo in general practice.

A double-blind, multi-centre study was carried out in general practice in 76 patients with infected eczema and 43 with impetigo to assess the effectiveness and acceptability of treatment with 1% hydrocortisone plus 0.5% potassium hydroxyquinoline sulphate cream compared with that of 1% hydrocortisone plus 2% miconazole nitrate cream. Patients were allocated at random to receive treatment with one or other preparation, applied twice daily, over a period of 2 weeks. Assessments were made of total symptom severity scores on entry and at the end of each week, as also were bacteriological investigations. The results showed that both combinations produced marked clinical and bacteriological improvement or cure in approximately 90% of patients with infected eczema and the success rate was similar with each preparation. In the case of patients with impetigo, hydrocortisone/potassium hydroxyquinoline sulphate proved significantly more effective than the other combination, the success rates being 92% and 74%, respectively. Patient assessment of the two topical preparations in terms of greasiness, odour and staining showed that, whilst both were considered acceptable by most, there was a trend in favour of the hydrocortisone/potassium hydroxyquinoline sulphate cream. No systemic or local side-effects were reported.

Adolescent↗
PubMed1985

An open trial of clotrimazole plus hydrocortisone cream in the treatment of napkin dermatitis in general practice.

An open, non-comparative, multi-centre study was carried out in general practice to assess the effectiveness, acceptability and tolerability of a 1% clotrimazole plus 1% hydrocortisone cream in the treatment of 112 infants with napkin dermatitis. The cream was applied twice daily to the affected area for 7 days and treatment was extended to 14 days for those who failed to respond adequately. Assessments made of the severity of symptoms showed that there was significant improvement in erythema, irritation and pustulation in all but a few patients and an overall impression of clinical response made at the last patient visit indicated that 92% of the patients were considered to have been cured or markedly improved. Acceptability and tolerability were good. In 2 cases, parents reported adverse reactions of discomfort during application of the cream and in 1 of these cases treatment was withdrawn after 4 days.

Clinical Trials as Topic↗
PubMed1983

Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough.

Two hundred and seventeen patients between 6 and 12 years of age suffering from acute cough took part in a randomized, single-blind study comparing 'Pholcolix' and 'Actifed' Compound. No significant difference in efficacy was demonstrated but analysis of palatability components (taste, smell, aftertaste and feeling in the mouth) showed numerical superiority for 'Pholcolix' for all parameters, with a high degree of significance for overall taste. 'Pholcolix' caused significantly fewer side-effects, with 'Actifed' Compound causing markedly more drowsiness after daytime dosage.

Acetaminophen↗
PubMed1983

Clenbuterol and salbutamol in the symptomatic treatment of patients with reversible airways obstruction.

In a single-blind, partially randomized, crossover study, 48 patients with reversible airways obstruction were treated with 4 mg salbutamol 3-times daily, 20 micrograms clenbuterol twice daily and 40 micrograms clenbuterol twice daily, each regimen being given for 2 weeks. With all treatments there was an improvement in lung function, as indicated by daily monitoring of PEFR and subjective assessment of breathing, and there were no significant differences between them. Side-effects were few. It is considered, therefore, that twice daily regimens of clenbuterol can be as effective as salbutamol given 3-times daily and this may help to improve patient compliance.

Adolescent↗
PubMed1982

A comparison between Gastrils and Aludrox in the treatment of gastric hyperacidity in general practice.

A single-blind multicentre crossover study was carried out in general practice of 47 patients with symptoms due to hyperacidity. Patients were allocated at random to receive treatment either with Gastrils for the first 2 weeks followed by Aludrox tablets for the second 2 weeks, or with Aludrox tablets for the first 2 weeks followed by Gastrils for the second 2 weeks. Clinical evaluation took place initially, after the first 2 weeks treatment and after the second 2 weeks treatment. The efficacy and acceptability of both preparations were compared, likewise the flavours of different Gastrils packs. Analysis of the results showed that peppermint flavoured Gastrils were significantly preferred to Aludrox tablets, and a peppermint flavour to a banana flavour. Side-effects were significantly more prevalent with Aludrox tablets. Differences in antacid response were similar, but numerically, if not statistically significantly, Gastrils had a more beneficial effect.

Adolescent↗
PubMed1982

Do all diuretics have equal hypotensive efficacy?

An open parallel study was carried out in general practice on 70 patients with uncomplicated mild to moderate hypertension to compare the hypotensive efficacy of hydrochlorothiazide/amiloride with that of cyclopenthiazide/potassium. After a 2-week baseline period on placebo, patients were allocated at random to receive treatment with one or other of the diuretics starting with 1 tablet per day and increasing up to a maximum of 4 tablets per day or until their supine diastolic blood pressure was 90 mmHg or less. They were then continued at their optimum dose for a further 4 weeks. Analysis of the results from 62 patients showed that the hydrochlorothiazide/amiloride preparation produced both a greater decrease and better control of blood pressure in a greater percentage of patients that did the comparison diuretic. In addition, the beneficial effects were attained with fewer tablets, of importance for patient compliance.

Adult↗
PubMed1980

Comparative study of cefaclor and amoxycillin in the treatment of respiratory tract infections in general practice.

A single-blind, randomized study was carried out in 101 general practice patients with respiratory infection to compare the effectiveness of 250 mg cefaclor 3-times daily with that of 250 mg amoxycillin 3-times daily. Assessment of 5 specific symptoms was carried out by the doctor before treatment and again 1 week later, and patients recorded their own opinion of any change in their condition. The results suggest that cefaclor was at least as effective as amoxycillin in producing resolution or improvement in symptoms and the median time to maximum response was somewhat shorter. Only 1 patient (on cefaclor) had a side-effect sufficiently severe to warrant cessation of therapy.

Adolescent↗
PubMed1978

A controlled study of diflunisal in sprains and strains.

A preliminary double-blind, randomized trial was carried out in general practice to compare the efficacy of treatment with diflunisal (500 mg) twice daily and a combination of dextropropoxyphene (65 mg) plus paracetemol (650 mg) 3-times daily for 3 days in relieving pain associated with strains and sprains. Analysis of the results from 51 patients showed that both treatments were equally effective in releiving spontaneous pain and pain on movement after 1 and 3 days, and there were no differences between the two groups in patients' overall evaluation of treatment or physicians' assessment of therapeutic response. Both treatments were well tolerated during the short-term period of the trial.

Acetaminophen↗