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J J Heys

Publications and source records attributed to J J Heys.

3 recordsLinked to original sources

First-order system least-squares (FOSLS) for modeling blood flow.

The modeling of blood flow through a compliant vessel requires solving a system of coupled nonlinear partial differential equations (PDEs). Traditional methods for solving the system of PDEs do not scale optimally, i.e., doubling the discrete problem size results in a computational time increase of more than a factor of 2. However, the development of multigrid algorithms and, more recently, the first-order system least-squares (FOSLS) finite-element formulation has enabled optimal computational scalability for an ever increasing set of problems. Previous work has demonstrated, and in some cases proved, optimal computational scalability in solving Stokes, Navier-Stokes, elasticity, and elliptic grid generation problems separately. Additionally, coupled fluid-elastic systems have been solved in an optimal manner in 2D for some geometries. This paper presents a FOSLS approach for solving a 3D model of blood flow in a compliant vessel. Blood is modeled as a Newtonian fluid, and the vessel wall is modeled as a linear elastic material of finite thickness. The approach is demonstrated on three different geometries, and optimal scalability is shown to occur over a range of problem sizes. The FOSLS formulation has other benefits, including that the functional is a sharp, a posteriori error measure.

Algorithms↗

Modeling passive mechanical interaction between aqueous humor and iris.

Certain forms of glaucoma are associated with displacement of the iris from its normal contour. We present here a mathematical model of the coupled aqueous humor-iris system that accountsfor the contribution of aqueous humor flow and passive iris deformability to the iris contour. The aqueous humor is modeled as a Newtonian fluid, and the iris is modeled as a linear elastic solid. The resulting coupled equation set is solved by the finite element method with mesh motion in response to iris displacement accomplished by tracking a pseudo-solid overlying the aqueous humor. The model is used to predict the iris contour in healthy and diseased eyes. The results compare favorably with clinical observations, supporting the hypothesis that passive iris deformation can produce the iris contours observed using ultrasound biomicroscopy.

Aqueous Humor↗

Permeability and diffusion in vitreous humor: implications for drug delivery.

PURPOSE: Previous experimental work suggests that convection may be important in determining the biodistribution of drugs implanted or injected in the vitreous humor. To develop accurate biodistribution models, the relative importance of diffusion and convection in intravitreal transport must be assessed. This requires knowledge of both the diffusivity of candidate drugs and the hydraulic conductivity of the vitreous humor. METHODS: Hydraulic conductivity of cadaveric bovine vitreous humor was measured by confined compression tests at constant loads of 0.15 and 0.2 N and analyzed numerically using a two-phase model. Diffusion coefficient of acid orange 8, a model compound, in the same medium was measured in a custom-built diffusion cell. RESULTS: Acid orange 8 diffusivity within vitreous humor is about half that in free solution. When viscous effects are properly accounted for, the hydraulic conductivity of bovine vitreous humor is 8.4+/-4.5 x 10(-7) cm2/Pa x s. CONCLUSIONS: We predict that convection does not contribute significantly to transport in the mouse eye, particularly for low-molecular-weight compounds. For delivery to larger animals, such as humans we conclude that convection accounts for roughly 30% of the total intravitreal drug transport. This effect should be magnified for higher-molecular-weight compounds, which diffuse more slowly, and in glaucoma, which involves higher intraocular pressure and thus potentially faster convective flow. Thus, caution should be exercised in the extrapolation of small-animal-model biodistribution data to human scale.

Animals↗