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Biomedical subjects

J J Keuning

Publications and source records attributed to J J Keuning.

18 recordsLinked to original sources
PubMed1992

Lymph node histology simulating T-cell lymphoma in adult-onset Still's disease.

A patient with adult-onset Still's disease (AOSD) underwent lymph node biopsy as part of initial evaluation for fever of unknown origin. The lymph node histology showed a massive, diffuse immunoblastic hyperplasia, simulating T-cell lymphoma. This nodal histology differs from rheumatoid arthritis, where mostly a follicular B-cell reaction predominates. Evaluating fever of unknown origin when one is unacquainted with this massive immunoblastic hyperplasia can lead to the wrong diagnosis of T-cell lymphoma in patients with AOSD.

Adult↗
PubMed1986

Primary malignant lymphoma of the uterine cervix associated with cold-reacting autoantibody-mediated hemolytic anemia.

A 66-year-old woman presented with autoimmune hemolytic anemia of the cold antibody type as one of the first symptoms of a non-Hodgkin lymphoma (NHL) localized primarily in the uterine cervix. Cold-reacting autoantibody-mediated hemolytic anemia is a rare complication of NHL. Its occurrence as one of the presenting symptoms of NHL is even more unusual. The incidence of a primary malignant lymphoma in the genital tract is low. The combination of these phenomena in one patient make this case unique in the English literature.

Aged↗
PubMed1977

Evidence for two series of B-cell antigens in man and their comparison with HLA-D.

Population and family studies of five sera with antibodies against B-cell determinants show an excellent fit of some of them with the HLA-D determinants, suggesting that the HLA-D determinants themselves or closely linked structures can be recognized by serology. One serum, Ag, might be coded for by a locus different from HLA-D, which could be located between HLA-A and -B. A two-color fluorescence test to detect B-cell antigens was used and found to save time and reagents and to give very good results.

B-Lymphocytes↗
PubMed1976

HLA-DW3 associated with coeliac disease.

28 patients with coeliac disease (C.D.) were typed for the HLA-A, -B, and -D loci by several techniques. It was found that C.D. is primarily associated with the DW3 determinant and only secondarily with HLA-B8. The previously described association with HLA-B8 is explained by linkage disequilibrium between HLA-B8 and DW3.

Adult↗
PubMed1976

B-cell antibodies, Ia-like determinants, and their relation to MLC determinants in man.

The HLA supergene is located in the 6th chromosome. Its position to the centromere and the position of a number of polymorphic isoenzymes has been elucidated. The HLA supergene codes not only for determinants present on all nucleated cells, but also for determinants present on B cells and absent from T cells and platelets. These determinants can be recognized by serology, and evidence is presented that some of them are coded for by a hither to unrecognized locus Ag, which is very closely linked to the MLC determinants of the D locus can be recognized with the help of the MLC test using unprimed cells, homozygous for the MLC determinants, so-called typing cells primed against one MLC determinant in the PLT test. So far, 8 MLC determinants have been recognized. Significant disease-association studies in different racial groups appear to be especially informative. They already indicate that the association found so far must rest on different mechanisms. Whether some of them could be caused by partial deficiency for one or more of the complement factors remains to be proven.

Animals↗
PubMed1975

The serological recognition of the human MLC determinants using a modified cytotoxicity technique.

A new approach which presumably recognizes MLC determinants (or at least structures closely linked to MLC and different from the FOUR, AJ and LA series determinants) by serology is described. As the test can be performed within 10 h it could be used to match cadaveric kidney donors for these MLC determinants. Perhaps even more important is the fact that the antibodies detected by this technique could be used to study the immunochemistry of a class of determinants differing from the well known SD determinants.

Antibodies, Anti-Idiotypic↗