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Biomedical subjects

J J Korten

Publications and source records attributed to J J Korten.

At least 19 recordsLinked to original sources
PubMed1999

Transcortical sensory aphasia in a right-handed patient following watershed infarcts in the right cerebral hemisphere: a 15-month evaluation of another case of crossed aphasia.

Well-documented cases of crossed (transcortical sensory) aphasia, especially those with longitudinal evaluation, are rare. We report a case of crossed transcortical sensory aphasia following watershed infarcts in the right hemisphere, from the moment of the accident until 15 months afterward. The aphasia type, and the course of recovery, is a "mirror" representation of that seen in cases of uncrossed aphasia. Unfortunately, the data do not permit strong conclusions regarding the lateralization of language in association with praxis and visuospatial abilities. This underlines the need for more well-documented (case) studies to come to a better understanding of the mechanisms through which lateralization occurs.

Aged↗
PubMed1996

[Epileptic insults, cerebral infarction and rhabdomyolysis as complications of amphetamine use].

In a 16-year-old boy with acute generalised epileptic convulsions, cerebral infarction and rhabdomyolysis were diagnosed. The urine was positive for amphetamine. Until that moment the patient had denied using drugs. He recovered and was discharged after nine days. Recreational use of ecstasy (methylenedioxymethamphetamine) and other amphetamine derivatives is gaining popularity worldwide. This drug abuse is rarely reported spontaneously.

3,4-Methylenedioxyamphetamine↗
PubMed1995

Absorption of clonazepam after intranasal and buccal administration.

Serum concentrations of clonazepam after intranasal, buccal and intravenous administration were compared in a cross-over study in seven healthy male volunteers. Each subject received a 1.0 mg dose of clonazepam intranasally and buccally and 0.5 mg intravenously. A Cmax of 6.3 +/- 1.0 ng ml-1 (mean; +/- s.d.) was measured 17.5 min (median) (range 15-20 min) after intranasal administration. A second peak (4.6 +/- 1.3 ng ml-1) caused by oral absorption was seen after 1.7 h (range 0.7-3.0 h). After buccal administration a Cmax of 6.0 +/- 3.0 ng ml-1 was measured after 50 min (range 30-90 min) with a second peak of 6.5 +/- 2.5 ng ml-1 after 3.0 h (range 2.0-4.0 h). Two minutes after i.v. injection of 0.5 mg clonazepam the serum concentration was 27 +/- 18 ng ml-1. It is concluded that intranasal clonazepam is an alternative to buccal administration. However, the Cmax of clonazepam after intranasal administration is not high enough to recommend the intranasal route as an alternative to intravenous injection.

Absorption↗
PubMed1994

Occult cerebrovascular malformations: 2 cases.

Since the introduction of high accuracy CT scanning and MR imaging, angiographically occult cerebrovascular malformations are a relatively common finding. The clinical presentation is usually related to hemorrhage. Asymptomatic intralesional bleeding frequently occurs. Currently, MR imaging is the most sensitive method for the detection of occult cerebrovascular malformations. The dynamic nature of these malformations seems to be a key factor in their therapeutic management. We present 2 cases of occult cerebrovascular malformations and discuss the clinical presentation, neuroradiologic appearance and current management of these lesions.

Adult↗
PubMed1993

Acinetobacter, an infrequent cause of community acquired bacterial meningitis.

A 19-year-old previously healthy woman developed meningitis due to Acinetobacter calcoaceticus. This is a Gram-negative coccobacillus belonging to the family Neisseriaceae. Most reported cases of Acinetobacter meningitis were hospital-acquired and due to strains highly resistant to amoxycillin. Our patient was treated with amoxycillin and recovered without sequelae.

Acinetobacter Infections↗
PubMed1990

Which risk factors predict the levodopa response in fluctuating Parkinson's disease?

Three putative risk factors to the pathogenesis of end-of-dose-related fluctuations--severity of Parkinson's disease (PD), duration of PD, and duration of levodopa therapy--were evaluated in 39 patients with PD by measuring response duration and response magnitude to a single levodopa dose. After discontinuing levodopa therapy for 12 hours, the motor status of each patient was assessed before a single dose of 100 mg of levodopa plus 25 mg of decarboxylase inhibitor was given and at five 45-minute intervals thereafter. Multiple regression analysis showed that the response duration was best predicted by the severity of PD. The response magnitude was significantly correlated both to the duration of PD and to the duration of levodopa therapy. It is argued, however, that the response magnitude was predicted by the duration of levodopa therapy. Our results are in accordance with those of other recent studies and indicate that variances in levodopa response duration and in levodopa response magnitude are caused by their own differential risk factor.

Adult↗
PubMed1988

Unilateral involuntary movements of acute onset in the adult, nine case reports and an alternative pathophysiological hypothesis.

During the last decade nine adult patients were seen with an unilateral choreoathetosis or choreoballism of acute onset. In seven a hemodynamically significant lesion in a carotid artery has been detected; in four the artery was completely occluded. In one there was a subclavian steal syndrome, and in another the etiology remained unclear. Three patients had their dyskinesia at the same side as the carotid artery lesion, and four at the controlateral side.

Aged↗
PubMed1988

Neurological manifestations of the hypereosinophilic syndrome (HES).

The hypereosinophilic syndrome (HES) is a rare disease, characterized by a long lasting hypereosinophilia of the blood and the marrow and by the presence of varying internal symptoms and frequent neurological signs. These latter can be as well central: encephalomalacy, organic psycho-syndrome, as peripheral: polyneuropathy or mononeuropathia multiplex, autonomic neuropathy and in rare cases a polymyositis. The disease clinically resembles very to periarteriitis nodosa (PAN). However, the prognosis of HES is far better, especially when early recognized and adequately treated.

Adrenal Cortex Hormones↗
PubMed1987

Electrooculographic findings in progressive supranuclear palsy.

Progressive supranuclear palsy is a heterogeneous system degeneration. We studied three patients by means of electrooculography. There were severe disturbances in saccadic and smooth pursuit eye movements, and optokinetic nystagmus in both vertical and horizontal planes. Caloric reactions were absent in all patients. The absence of vestibular reflex responses in contrast to the normal results in doll's head manoeuvre seems contradictory and is discussed. From the results in our patients it is concluded that E.O.G. is an essential contribution in proving a multiple system pathology.

Aged↗
PubMed1985

Ossification of the posterior longitudinal ligament.

Two non-Japanese patients with ossification of the cervical posterior longitudinal ligament were described. This abnormality is very common in Japan, but rare in non-Japanese people. The reason is unknown. Although the disease appears to be generally asymptomatic, it can cause a myelopathy. The clinical picture, the diagnostic important X-ray examinations and the histopathological findings are revealed. The similarity to the vascular pattern in the lumbar spine in cases of intermittent neurogenic claudication is noted.

Aged↗
PubMed1980

Olfactory disturbances in Parkinsonism.

Disturbance of smell should be regarded as a common symptom of Parkinson's disease. It often presents as a precursor of the motor disability. The common underlying cause might be the deficiency of catecholamines in the brain of Parkinson patients, especially in the mesolimbic projection areas.

Discrimination Learning↗
PubMed1977

Chronic progressive external ophthalmoplegia in a heredo-ataxia: neurogenic or myogenic? A clinical, neuropathological and submicroscopic study.

A patient with Friedreich's disease and chronic progressive external ophthalmoplegia is descirbed. An investigation was performed into the nature of the ocular motor disorders, which appeared clinically to be supranuclear. The EMG of the ocular muscles suggested myopathy. A specimen of ocular muscle was obtained by biopsy and examined with the light microscope and-for the first time-under the electron microscope. Signs of mitochondrial myopathy were found alongside neurogenic features. Postmortem examination of the central nervous system confirmed the diagnosis of Friedreich's disease with lesions of the motor cells in the anterior horn of the spinal cord. No evidence was found for a supranuclear or inernuclear origin of the ocular palsies, but 20-30 per cent of the neutrons in the nuclei III and IV were atrophic. Lesions of the non-medullated motor nerve fibres were also visible under the electron microscope. That the origin of the c. p. e. o. in this heredo-ataxia is neurogenic-nuclear is postulated on the grounds of the neuropathological and electronmicroscopic findings. Resemblances to the microscopic and submicroscopic and submicroscopic appearance of many types of "ocular myopathy" and "ophthalmoplegia-plus" throw doubt upon the myogenic character of these conditions. Possibly chronic, slowly progressive atrophy in the nuclear areas of the ocular motor nerves must in these cases also be held responsible for the c. p. e. o. Perhaps Moebius's Kern-Schwund theory may be revived after 85 years.

Adult↗
PubMed1976

Myoclonic disorders of spinal origin.

Data in the literature on spinal myoclonic disorders are still scanty; little has been done to ensure an adequate classification; little is known about the pathophysiology of these disorders. Three patients with spinal myoclonic jerks are described, with detailed reference to electromyographic findings. On the basis of the case reports so far available, a classification into five subgroups is suggested of spinal myoclonic jerks: 1) after cord injuries; 2) associated with intramedullary cord tumours; 3) associated with intramedullary or extramedullary cysts; 4) associated with radiculomyelitis or myelopathy; 5) associated with affections of the alpha motoneurons. A number of hypotheses on the pathogenesis of this disorder are briefly discussed: peripheral or intraspinal sprouting, degeneration of alpha motoneurons or interneurons, reduction of the dendritic tree size, and involvement of the gamma system.

Adult↗
PubMed1975

Madopar versus sinemet. A clinical study on their effectiveness.

Fifteen well-documented Parkinson patients treated with Madopar were switched to Sinemet for 3 months. The results were measured with an objective test procedure and compared. The effects of Madopar and Sinemet were equal provided th amount of levodopa was the same. There was one drop-out, because of ventricular extrasystoles. Attention is paid to the occurrence of involuntary hyperkinesias and the on-off-effect.

Adult↗
PubMed1975

Trisomy 4p in a family with A t(4;15).

This report concerns a trisomy 4p in a mentally retarded girl with multiple congenital anomalies. A translocation between chromsomes Nos. 4 and 15 was discovered in three generations of the patient's pedigree.

Abnormalities, Multiple↗