Biomedical subjects

J J Lucey

Publications and source records attributed to J J Lucey.

3 recordsLinked to original sources

PubMed1976

Fatal graft-versus-host disease following transfusion of granulocytes from normal donors.

A case of fatal graft-versus-host disease was seen in an adult with acute leukaemia, after transfusion of leucocytes from normal donors. This is the first reported case of graft-versus-host disease following transfusion of normal blood-products to a patient with a disease not usually associated with severe immunoincompetence. The number of lymphocytes transfused was no higher than that given when platelet concentrates are prepared from a single donor.

Graft vs Host Disease↗

PubMed1975

Raised intracranial pressure due to spinal tumours: 3 rare cases with a probable common mechanism.

Three cases are reported of raised intracranial pressure associated with spinal tumours. The theories which have been advanced to explain this complication are discussed and it is suggested that in many of the reported cases the underlying mechanism may have been intracranial spread of the tumour and not a blockage of the cerebrospinal fluid pathways with proteinaceous deposits, as has been widely maintained. Autopsy revealed the former process to have operated in 2 of the 3 cases and it may have done so in the third. Two cases had unusual features in common: they were malignant schwannomas (a very rare spinal tumour) and they had both developed within the field of irradiation given for benign conditions many years previously.

Adult↗

PubMed1975

Spontaneous infarction of the breast.

Five cases of infarction of physiological hyperplastic breast tissue associated with pregnancy or lactation are reported. These presented clinically as lumps in the breast, two of which were painful. Similar cases in the literature are briefly reviewed. The demonstration of an underlying lobular pattern in the present cases and the distribution of the infarcts support the view that the so-called 'adenoma' of pregnancy or lactation is a myth. Organizing vascular thrombi, previously unrecorded in this context, were seen in three of the five cases, and it is postulated that these lesions are the primary cause of the infarction rather than relative vascular insufficiency, as proposed by previous authors.

Adolescent↗