Biomedical subjects
Publications and source records attributed to J J Meyer.
A 6-month-old infant arrived at the emergency room with severe respiratory distress after being spoon-fed chicken soup. Air entry was normal, chest X-rays were normal, and bronchoscopy revealed a hollow chicken bone lining the whole left main bronchus.
The authors compared the renal toxicity of the low osmolality radiocontrast agents, iohexol and ioxaglate, and the ionic agent, iothalamate, at equivalent iodine dose, using experimental models in vitro and in vivo. In isolated perfused rat kidneys, all agents induced comparable biphasic hemodynamic changes, associated with similar declines in glomerular filtration rate (GFR) and tubular necrosis. In two different in vivo models (using multiple insults combined with the administration of radiocontrast), iothalamate appeared to induce more severe morphologic injury. Despite similar nephrotoxic potential in vitro, the newer radiocontrast agents, iohexol and ioxaglate, cause in vivo less renal injury than iothalamate in the experimental models.
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A pseudomonad was isolated from the fluoroacetate-producing plant Dichapetalum cymosum (Hook) Engl. and identified as Pseudomonas cepacia. We established that this isolate was capable of growing in fluoroacetate-enriched solutions without any reduction in growth rate. Our isolate of P. cepacia was capable of defluorinating 2.69 mg of fluoroacetate per 10(9) cells per h. Fluoroacetate was degraded to CO2 at a rate of 23.53 ng/10(9) cells per h.
Although numerous clinical thermographic studies are available, few basic science studies using thermography have been performed. As such, evidence suggesting the diagnostic use of thermography is often mired in the complexity of human ailments. This study thermographically evaluated the hind paws of rats. Rats acted as their own controls using the contralateral side as reference. Rats were separated into two groups: sham operated rats and rats with complete sciatic nerve transection. Rats that received sciatic transection were noted to have a 5.1 degrees C rise of the affected plantar hind paw immediately following transection. There was a statistical difference in right vs. left up to 42 days, and a return to symmetry at 63 days. The sham operated group did not experience a rise in temperature of the affected hind paw. Controlled animal studies of this type may be an aid in understanding clinical thermography.
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The comparison between complaints, functional defects and vitamin deficiencies is reported for several professional groups characterized by different work conditions. Results suggest that complaints are an useful indicator of visual load and that retinal sensitivity to the light is especially tried. Longitudinal studies are required to verify whether some functional alterations on the aging process of the eye can be aggravated by a visual overload. Visual complaints, functional defects and vitamin deficiencies as indicators of visual load.
Lesions of the seminal vesicle can be evaluated by the transrectal needle approach. Biopsy, aspiration of contents for culture and cytology, injection of contrast medium for x-ray and drainage of cysts or abscesses can be done with this approach.
A rare case of malignant paraganglioma of the urinary bladder with metastasis to a lymph node in a 12-year-old girl is reported, and eight other previously recorded cases are reviewed. Headache, fainting, and hypertension initiated by voiding were the most prominent clinical symptoms. Hematuria was present in three cases and aided in prompt diagnosis. Cystography, pelvic angiography, and cystoscopy were most diagnostic. Segmental cystectomy when feasible, was the preferred surgical treatment. The prognosis was slightly better than for other forms of extraadrenal pheochromocytomas.
Studies have been conducted of the respective effects a dose of 300 mg tetrabamate administered daily for one week, of 45 mg phenobarbital also given daily for one week (tetrabamate contains 15% phenobarbital) and of a small amount of alcohol alone or associated with one or the other of these drugs. Several perceptual-motor components involved in the driving function have been measured by testing signal detection of threshold contrast under mesopic vision following glare and without glare, critical fusion frequency, perceptual-motor reaction pattern for simple reaction time or choice reaction time during which the different signals do not appear with the same probability, and perceptual style by means of the rod-and-frame test.
It appears that visual complaints, as they are expressed by numerous TV screen operators, are associated with common eye defects. Our results based on a survey with questionnaires and visual testing sustain such an hypothesis. As a consequence, solving eye problems at TV screens requires both the improvement of visual displays and the visual adaptation of users. If impossible working-time should be reduced.
Psychophysical flicker thresholds and ERG flicker responses were compared with Farnsworth's 100-hue colour test data in cases of congenital and acquired vision deficiences. The results, evaluated in term of sensitivity and specificity lead to some practical and theoretical suggestions. In most cases, flicker responses and colour tests results were better than other classical tests for evaluating the first signs or gravity importance of a macular disturbance. Relatively minor differences between the 3 tests may be related to the observed or supposed extension of lesion in the macular area, but in some cases the observed functional changes can be understood only by admitting some lateral effect from one area to another. Generally acquired colour differences are associated with flicker response changes. In congenital red-green blindness of different gravity, moderate abnormal white light flicker responses could be observed. But they do not seem to be associated clearly with a type and gravity of the deficiency. With coloured stimuli, the difference between normal and red-green colour-blindness is more clear-cut, and red-blind can be discriminated from green-blind. Subclinical retinal pathology as well as specific stimulus conditions in normal and red-green colour-blind subjects reveal some non-linear processes in the low-frequency range of the temporal attenuation characteristics.
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There have been 14 cases of anterior urethral valves reported in the literature. The main diagnostic test in these cases has been voiding cystourethrography since retrograde urethrography is believed to be useless. Two additional cases of anterior urethral valves are presented to demonstrate the usefulness of the retrograde urethrogram as a valuable adjunctive diagnostic study.
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This study compares and verifies the efficiency of two functional tests based on intermittent light stimulation. One is the De Lange curve, the other flicker E.R.G. recorded in defined photopic conditions and analysed with different methods. The studied cases belong to a reference group and other groups including foveolar lesions, parifoveolar and diffuse retinopathy, ethambutol and quinoline derivative retinal intoxication. The results show that both objective and subjective methods are sensitive and show some parallelism : both methods aid in distinguishing between foveolar and perifoveolar involvements; a possible comparison between the two tests is also possible.
Averaged ERGs of rats treated with phenylmercury borate and methylmercury chloride were recorded. Amplitude differences were seen only with the latter treatment. A high Hg tot. level was found in eyes of animals treated with methylmercury.