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J J Molnar

Publications and source records attributed to J J Molnar.

17 recordsLinked to original sources
PubMed1987

Gonadal endodermal sinus (yolk sac) tumor with pure intestinal differentiation: a new histologic type.

We studied 3 cases of a variant of endodermal sinus tumor (EST) or yolk sac tumor (YST). Two tumors originated in the ovary and one in the testis. The patients had very high levels of serum alpha-fetoprotein (AFP). All three tumors had a characteristic histologic appearance and were composed of acinar structures lined by columnar epithelium with large, immature nuclei. Immunohistochemistry and electron microscopy, including freeze-fracture studies, confirmed that this unusual tumor is one with exclusive intestinal differentiation. We feel that this unique tumor is a pure EST (YST) with exclusive intestinal differentiation.

Adult↗
PubMed1986

Ovarian endodermal sinus tumor with intestinal differentiation.

A 12-year-old girl was admitted to the hospital for evaluation of an abdominal mass. A preoperative computed tomography scan showed a large tumor in the pelvis. The serum alpha-fetoprotein level was 2,170,000 ng/ml. A 3000-g left ovarian neoplasm was resected. It was encapsulated and showed focal microcystic degeneration, necrosis, and hemorrhage. Microscopically, it was composed of gland-like spaces containing mucin-positive material and surrounded by scant fibrovascular tissue. The epithelial cells were low columnar with immature oval, basophilic nuclei. Immunoperoxidase staining for alpha-fetoprotein and alpha1-antitrypsin were positive. Enzyme histochemistry was negative for alkaline phosphatase and positive for alpha-naphthyl acetate esterase. Electron microscopy, including freeze-fracture analysis, showed desmosomes and tight junctions. No gap junctions were identified. Actin filaments, glycogen, and microvilli were abundant. This is the first case of an ovarian endodermal sinus tumor with exclusive enteric differentiation.

Adolescent↗
PubMed1983

Recurrent endometrial malakoplakia.

The microscopic diagnosis of endometrial malakoplakia was made in a 69-year-old diabetic woman with metrorrhagia. Eight months later, her clinical symptoms returned. Repeat curettage confirmed the original diagnosis and established the case as the first example of recurrent endometrial malakoplakia.

Aged↗
PubMed1983

An unusual pedunculated polyp of the colon: association with schistosomiasis.

A patient with long-standing, nonspecific abdominal symptoms had a barium enema showing a single pedunculated polyp. This was removed by colonoscopic polypectomy and found to be an inflammatory polyp associated with Schistosoma mansoni infection. We review the relationship and significance of schistosomiasis to colonic polyps.

Barium Sulfate↗
PubMed1983

Copper storage in the liver of the wild mute swan (Cygnus olor). Its possible relation to pollution of harbor waters by antifouling paints.

Postmortem examination of three wild mute swans (Cygnus olor) from a harbor area disclosed an unusual black discoloration of the liver. Chemical, histochemical, and microscopic studies, along with electron-probe microanalysis, showed that cytoplasmic pigment granules in the liver cells contained a copper-protein complex. Similar findings have been reported in Danish and English studies on large numbers of wild mute swans. Two control mute swans from The Bronx Zoo had negligible amounts of hepatic copper. The striking difference between the wild and the captive swans in hepatic copper content suggests that the copper in the wild swans was of environmental origin, most likely from copper-rich antifouling paint used extensively in the marine industry. Flakes of this paint may be ingested by swans searching for food in the sediment of harbor waters.

Animal Population Groups↗
PubMed1982

Cervical cysts: cancer until proven otherwise?

A cystic neck mass can be either malignant or benign; 22% of patients (4/18) admitted with the tentative diagnosis of branchial cyst in a recent 2-year period (1977-1979) had metastatic carcinoma: epidermoid, thyroid or salivary gland. Preoperative fine needle aspiration was diagnostic in 1 instance and unhelpful in 2. Frozen section analysis of the gross specimen invariably provided the correct diagnosis. All patients with malignancies had subclinical primary disease and in 1 instance random biopsies identified its origin. The prudent surgeon will avoid untoward results if he approaches a neck cyst in an adult as if it were malignant. Guidelines he can follow to prevent the inadvertent removal of a metastasis under the misapprehension that it is a benign neck cyst include: 1. Prior to operation, perform a thorough head and neck examination to identify a primary carcinoma; 2. Do a fine needle aspiration of the mass for cytology. A negative report must be considered inconclusive; 3. Make a gross examination in the operating room of the opened cyst and frozen section processing of suspicious areas; 4. Follow with a panendoscopy and random biopsies of appropriate areas and complete the neck dissection on the involved side, after a metastatic deposit has been recognized. The preoperative procurement of contingency consent for these procedures is understood.

Adult↗
PubMed1980

Renal oncocytoma. Report of five cases and review of literature.

Cases of renal cell carcinomas seen between 1963 and 1977 were reviewed. Five of these cases (4.66%) were reclassified as renal oncocytomas. The distinctive appearance of this lesion is a well circumscribed, uniform tan-brown tumor with a prominent central scar and lack of necrosis or hemorrhage. Light and electron microscopy confirmed the oncocytic features of the tumor cells. A possible association with smoking is suggested. Angiographic studies may assist in preoperative diagnosis. The clinical course of patients with renal oncocytoma is definitely benign.

Adenoma↗