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Biomedical subjects

J J Morcos

Publications and source records attributed to J J Morcos.

8 recordsLinked to original sources

Tumor-associated hemorrhage in patients with acoustic neuroma.

OBJECTIVE: To describe the clinical significance of tumor-associated hemorrhage in patients with acoustic neuromas. STUDY DESIGN: Retrospective chart review. SETTING: University-based, tertiary care teaching hospital. PATIENTS: Three patients with acoustic neuromas who experienced symptomatic tumoral bleeding. INTERVENTIONS: Radiographic imaging, surgical removal of tumors, and pathologic analysis. MAIN OUTCOME MEASURES: Patient histories, radiologic characteristics, surgical results, and pathologic findings. RESULTS: Tumoral hemorrhage can occur in patients with acoustic neuromas. These three cases and a review of the world literature suggest that tumor size may be the most important risk factor for tumor-related hemorrhage. CONCLUSION: These findings have implications for those patients with acoustic neuromas who choose not to have surgical removal.

Aged↗

Microsurgical treatment of infratentorial malformations.

The brain stem has long lost the designation of "no-man's land." Armed with a detailed knowledge of skull base and parenchymal neuroanatomy, coupled with the advances in intraoperative mapping and monitoring, most intrinsic brain stem cavernous malformations can be resected microsurgically. Success continues to depend on proper patient selection, optimal timing, thorough planning, meticulous technique, and completeness of the resection.

Brain Stem↗

Successful living related liver transplantation in an adult with fulminant hepatic failure.

We report a case of an adult female who developed fulminant hepatic failure (FHF) during the second trimester of pregnancy and underwent a successful living related liver transplantation because no cadaveric donor was available during the development of life-threatening symptoms. A left lateral segment hepatic graft was procured from her brother, whose body weight was similar to hers. Her postoperative course was complicated by bleeding at the biliary anastomosis and subsequently by a biliary leak. Nevertheless, the complications were corrected surgically and the patient recovered well with a good quality of life 5 months after the transplant. This case suggests that living related liver transplantation should be considered more frequently for adult FHF patients. As the window of therapeutic opportunity is narrow for the dramatic condition of FHF, wide acceptance of this procedure will be of great benefit for the patients suffering from FHF.

Adult↗

Revascularization and aneurysm surgery: current techniques, indications, and outcome.

Revascularization is an important component of treatment for complex aneurysms that cannot be directly clipped and instead require parent vessel occlusion. A consecutive series of 61 patients with 63 aneurysms requiring cerebral revascularization is presented. Aneurysms were located along the petrous internal carotid artery (ICA) (n = 5), the cavernous ICA (n = 16), the supraclinoid ICA (n = 12), the middle cerebral artery (n = 17), the anterior cerebral artery (n = 4), the vertebral artery/posterior inferior cerebellar artery (n = 5), and the midbasilar artery (n = 4). Aneurysms were treated by direct clipping (n = 8), trapping (n = 28), proximal vessel occlusion (n = 9), distal vessel occlusion (n = 1), excision (n = 15), and thrombotic occlusion (n = 2). Revascularization was performed with petrous to supraclinoid ICA bypass (n = 12), superficial temporal artery to middle cerebral artery bypass (n = 15), superficial temporal artery to middle cerebral artery bypass with saphenous graft (n = 5), superficial temporal artery to superior cerebellar artery bypass (n = 4) long saphenous bypass (n = 11), in situ bypass (n = 3), and primary reanastomosis (n = 13). Fifty-seven patients (93%) had good outcomes, and one patient died (surgical mortality, 2%). This experience demonstrates that revascularization can be performed with low morbidity and mortality. We think that the cumulative risks of not performing revascularization in patients who tolerate ICA balloon occlusion exceed the surgical risk of revascularization. We therefore favor revascularization in patients with complex aneurysms treated by surgical arterial occlusion.

Adolescent↗

Multiple trauma in the achondroplastic dwarf: an emergency medicine physician perspective case report and literature review.

Although uncommon, the achondroplastic dwarf (AD) may become the victim of multiple trauma, presenting special challenges for the emergency department (ED) physician. Traditional management of airway, breathing, circulation, and neurological disability is altered by the unique anatomic features of achondroplasia. Despite facial abnormalities observed in the AD, orotracheal and nasotracheal intubation are usually accomplished without particular difficulty; however, abnormalities of the base of the skull and cervical spine make hyperextension of the neck especially hazardous in these patients. The lungs are functionally normal, although vital capacity is decreased and thoracic case abnormalities and abdominal obesity impair lung expansion. Vascular access in the AD is difficult. Peripheral access is difficult because of excessive subcutaneous fat, whereas central venous access is complicated by neck, chest wall, and spinal abnormalities that obscure commonly used anatomic landmarks. Major neurological syndromes observed in ADs are hydrocephalus, cervical medullary compression, and thoracolumbar stenosis. The ED physician should recognize these syndromes, their potential to produce neurological disability, and their unique implications for trauma.

Achondroplasia↗

History of brain stem surgery.

The earliest surgical procedures on the brain stem parenchyma were directed at sectioning specific fiber pathways to alleviate pain. Subsequently, some tumors, abscesses, and vascular lesions that displace rather than invade the parenchyma have been successfully removed. Future advances depend on the ability to preserve and restore neural function in operated tissue.

Brain Stem↗