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Biomedical subjects

J J Ortega-Albás

Publications and source records attributed to J J Ortega-Albás.

9 recordsLinked to original sources

Sleep disorder in alien hand syndrome.

A 63-year-old right-handed woman developed an alien hand syndrome (AHS) after an acute infarction in the territory of the left anterior cerebral artery. The uncontrolled hand movements were present during the daytime and eventually disturbed sleep. Polysomnography revealed that these motor actions only appeared when the patient was awake. These awakenings emerged mostly from NREM sleep stage 2 during the first half of the night. There was no evidence of any epileptiform activity, dyssomnia or parasomnia. These movements were controlled making her wear an oven mitt during sleep. The temporal distribution of this motor activity seems to follow the progressive hyperpolarization of anterior horn neurons that occurs when sleep deepens. The accommodation of the grasp reflex in AHS probably helps control this unwanted motor activity.

Anterior Horn Cells↗

[Electroencephalography in Creutzfeld-Jakob disease].

INTRODUCTION: The electroencephalogram is very useful in the diagnosis of probable Creutzfeldt-Jakob disease. DEVELOPMENT: It is considered that a typical pattern is formed of periodic sharp wave complexes, widely distributed (synchronously and symmetrically) over both cerebral hemispheres. The frequency of presentation is approximately 1/second. However during the course of the disease other patterns are seen, such as frontal intermittent rhythmical delta activity, a cyclical alternating pattern and a low output electroencephalogram. CONCLUSION: Recognition of these patterns, their electroclinical correlation and serial polygraphic studies are very important to the reliability of the test.

Creutzfeldt-Jakob Syndrome↗

[Neurophysiology in Creutzfeldt-Jakob disease].

INTRODUCTION: Neurophysiological studies conducted in subjects who it is suspected are suffering from Creutzfeldt-Jakob disease (CJD) are usually aimed at searching for what is called a typical EEG. However, the EEG is a dynamic test and therefore subject to variations in time. Furthermore, there are other kinds of neurophysiological tests that may also be of interest, and the lack of typical traces in the new variant of the disease forces us to explore other diagnostic approaches. METHOD: We performed a clinical EEG correlation in the course of the evolution of the disease, in which we observed a significant variability throughout the different stages. We then review the neurophysiological studies that have been conducted on CJD, in which shortcomings and important discrepancies can be seen. CONCLUSION: EEG has proved to be a fundamental element in CJD probability diagnosis. It is also found that sleep and waking records, obtaining series of EEGs, the detection of poligraphic changes related with variations in the degree of consciousness and, lastly, studies conducted by means of other neurophysiological techniques associated with clinical data will all undoubtedly enable us to achieve higher efficiency in diagnosis

Blinking↗