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J J Phair

Publications and source records attributed to J J Phair.

4 recordsLinked to original sources
PubMed1985

Chronic cutaneous granulomatous dermopathy: morphologic and serologic evaluation, differential diagnosis and pharmacologic control.

We report on a syndrome of disfiguring lower extremity cutaneous lesions of 6 years duration. Previous medical evaluations included 5 skin biopsies and several therapeutic regimens which did not alter the course of illness. The histologic interpretations of skin biopsies included panniculitis, papulonecrosis, and granuloma. One biopsy was interpreted as a localized cutaneous vasculitis with a wedge-shaped infarct. Infectious, collagen vascular, and factitious etiologies could not be demonstrated to explain the patient's lesions. The Chicago Dermatological Society included in their differential diagnosis bacterial allergy, including the tuberculoid reaction. Mycobacterium tuberculosis as the etiology was dismissed by negative cultures, histologic staining and failure of response to antituberculous therapy. Our report includes a series of immunologic tests that might be consistent with but do not definitively establish a bacterial hypersensitivity reaction to explain this patient's skin lesions. Despite a lack of proven etiology dramatic improvement occurred with corticosteroid therapy.

Adrenal Cortex Hormones↗
PubMed1982

Bronchopulmonary torulopsosis.

A patient had clinical and radiographic findings suggestive of allergic bronchopulmonary aspergillosis. Further studies excluded this diagnosis but indicated that the patient's respiratory disease was due to the yeast Torulopsis glabrata, usually nonpathogenic in normal human hosts. The patient had no evidence of invasive disease. Total serum IgE was elevated but IgE antibody against T. glabrata could not be demonstrated by skin test or radioimmunoassay. Demonstration of elevated IgG antibody against T. glabrata antigen by radioimmunoassay was of value in suggesting the diagnosis. The patient responded to prednisone therapy with clinical and radiographic improvement and with a sharp decline in total serum IgE, and a lesser degree of decline in total serum IgG and IgA. Bronchopulmonary torulopsosis may be rare but should be considered in cases where the diagnosis of allergic bronchopulmonary aspergillosis cannot be established. Because IgE antibody could not be incriminated in this disease the term allergic bronchopulmonary torulopsosis was not used in this case.

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