Biomedical subjects

J J Qin

Publications and source records attributed to J J Qin.

2 recordsLinked to original sources

PubMed2000

New digital measurement methods for left ventricular volume using real-time three-dimensional echocardiography: comparison with electromagnetic flow method and magnetic resonance imaging.

AIM: The aim of this study was to investigate the feasibility and accuracy of using symmetrically rotated apical long axis planes for the determination of left ventricular (LV) volumes with real-time three-dimensional echocardiography (3DE). METHODS AND RESULTS: Real-time 3DE was performed in six sheep during 24 haemodynamic conditions with electromagnetic flow measurements (EM), and in 29 patients with magnetic resonance imaging measurements (MRI). LV volumes were calculated by Simpson's rule with five 3DE methods (i.e. apical biplane, four-plane, six-plane, nine-plane (in which the angle between each long axis plane was 90 degrees, 45 degrees, 30 degrees or 20 degrees, respectively) and standard short axis views (SAX)). Real-time 3DE correlated well with EM for LV stroke volumes in animals (r=0.68-0.95) and with MRI for absolute volumes in patients (r-values=0.93-0.98). However, agreement between MRI and apical nine-plane, six-plane, and SAX methods in patients was better than those with apical four-plane and bi-plane methods (mean difference = -15, -18, -13, vs. -31 and -48 ml for end-diastolic volume, respectively, P<0.05). CONCLUSION: Apically rotated measurement methods of real-time 3DE correlated well with reference standards for calculating LV volumes. Balancing accuracy and required time for these LV volume measurements, the apical six-plane method is recommended for clinical use.

Adult↗

PubMed1993

Relation between coronary artery geometry and the distribution of early sudanophilic lesions.

The relationship between the angle formed by the left circumflex (LCX) and left anterior descending (LAD) coronary arteries at the bifurcation of the left main coronary artery (LM) and the location of sudanophilia in the proximal portions of the LCX and LAD, was investigated, using a normalized index of disease severity (relative proximal involvement, RPI) to isolate the local effect of geometry on the predisposition to disease from that of other risk factors. Multiplane angiograms of the left coronary artery system of 15 hearts were digitized and processed to form a three-dimensional representation of the centerline of the lumen (termed the 'axis') of each coronary segment; the LM branch angle was objectively computed from the reconstruction. The coronary vessels were fixed in situ, removed from the hearts, opened longitudinally and stained with Sudan IV. The RPIs of the LAD and LCX were obtained by dividing the percentage sudanophilia seen en face in the first 1 cm of each vessel by the percentage sudanophilia in the first 5 cm. RPI was correlated negatively with LM branch angle, suggesting that a small LM branch angle may be a 'geometric risk factor' for proximal atherosclerotic disease in the daughter vessels. The correlation was stronger for the LCX than the LAD. These results would appear to be consistent with the notion that atherosclerosis is favored where a larger extent of the vessel experiences fluid dynamic wall shears near zero for an appreciable part of the pulsatile cycle.

Adolescent↗