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J J Regan

Publications and source records attributed to J J Regan.

At least 19 recordsLinked to original sources
PubMed1991

Personality and family history of depression in patients with affective illness.

The presence of a family history of depression may distinguish clinically important subgroups of depressed patients. Depressed patients with and without a family history of depression may differ on several clinical features. There are limited data, however, on potential differences in personality variables between patients with and without familial depression. We examined personality measures in 41 depressed subjects with and without a familial history of depression in both the depressed and remitted state. Patients with no family history of depression had significantly higher mean personality trait scores on the dependent and compulsive personality scales. The clinical and theoretical implications of these findings are discussed.

Adult↗
PubMed1991

The effect of sensory deprivation in the reduction of pain in patients with chronic low-back pain.

Patients who suffer from persistent pain for prolonged periods of time (6 months or more) are often influenced to an increasing extent by psychological factors. Patients begin to focus on their pain as the problem rather than its physical origin. This study evaluated the effectiveness of sensory deprivation in reducing pain in patients with chronic low-back pain. Sixty patients were divided into two groups of 30 patients each: One group underwent 1 hour of sensory deprivation; the other received a lecture on relaxation skills. In the group receiving sensory deprivation, statistically significant decreases in pain and stiffness were noted. Sensory deprivation is an effective treatment to reduce pain and thus interrupt the pain cycle in patients with chronic low-back pain.

Adult↗
PubMed1989

Personality and response to tricyclic antidepressants in depressed patients.

Several studies have shown that disturbances of personality are poor predictors of response to antidepressants. None of these studies, however, has used personality measures similar to the DSM-III. We evaluated the relationship between antidepressant response and personality scores obtained on the Millon Clinical Multiaxial Inventory, which provides personality measures congruent with DSM-III. Personality features such as assertiveness, independence, and competitiveness distinguished responders from nonresponders. However, the frequency of personality disorder diagnoses did not differ between responders and nonresponders.

Adult↗
PubMed1988

Personality and depression.

Several studies suggest that measures of personality traits and disorders are affected by depressed state. However, none of the studies to date have evaluated the effect of depressed mood on personality using current diagnostic criteria. The effect of depressed mood on personality scale scores and personality disorder diagnoses using the Millon Clinical Multiaxial Inventory was assessed in 42 depressed patients. There was a significant alteration in mean personality trait scores and reduction in personality disorder diagnosis between the depressed and remitted states. The clinical and theoretical implications of these findings are discussed.

Adult↗
PubMed1988

Discitis after discography.

A series of nine patients with post-discography discitis were evaluated to help delineate the clinical course. The most consistent sign was the marked exacerbation of neck or back pain. This then was followed by an elevated sedimentation rate at an average of 20 days, followed by a positive bone scan at an average of 33 days. Of note is that seven patients initially had negative bone scans at an average of 18 days. Five out of nine patients had changes on plain roentgenograms between 14 and 51 days after discography. Magnetic resonance imaging was performed in six patients; two of these patients were scanned twice. Three scans were negative and five were positive (2 patients initially had negative scans that later became positive). The course of lumbar discitis ranged from 8 to 11 weeks, and cervical discitis from 6 to 7 weeks, with the latter usually resulting in spontaneous fusion.

Adult↗
PubMed1988

Personality features of obsessive-compulsive disorder.

The authors evaluated personality dysfunction in 23 patients with primary obsessive-compulsive disorder and an age- and sex-matched group of patients with major depressive disorder. There were no significant differences between the two patient groups with respect to mean personality trait scores or the frequency or type of personality disorder diagnosis. A mixed personality disorder with avoidant, dependent, and passive-aggressive features was most commonly observed in the obsessive-compulsive group. There was a very low frequency of schizoid or compulsive personality disorder.

Adult↗
PubMed1988

The biomechanical and histomorphometric properties of anterior lumbar fusions: a canine model.

An in vivo model was developed to compare the biomechanical stability, incidence of radiographic union, bone formation rate, and bone graft remodeling parameters of anterior interbody fusions. Eighteen 1-year-old beagles underwent anterior and posterior spinal destabilization procedures at L5-L6 to produce a reproducible amount of spinal instability--resection of the anterior longitudinal ligament, L5-L6 intervertebral disk, L5 and L6 lamina, spinous processes, zygoopophyseal joints, and ligamentum flavum. Group I (N = 6) were surgically destabilized controls; Group II (N = 6) underwent anterior L5-L6 interbody fusion with iliac crest bone graft; and Group III (N = 6) underwent anterior stabilization with a longitudinal fibular strut graft in addition to the same operative procedure as Group II. Six months postoperatively the group with the highest incidence of successful radiographic L5-L6 arthrodesis was Group III, anterior interbody fusion and fibular stabilization (p less than .10). The rank order of biomechanical stability was the same for the three groups for both torsional and axial compressive stiffness, with Group I (destabilized controls) being the least rigid, then Group II (anterior fusion with iliac crest grafting only), and the most rigid to both torsion and axial compressive loading was Group III (anterior fusion with fibular stabilization and iliac crest bone graft). The bone formation rate [mm3/(mm3 x year) x 10(3)], which was derived from the distance between fluorochrome markers, revealed that the more stable the individual spinal construct, the lower the bone formation rate. In summary, the beagle provided a successful model for studying in vivo the response of anterior bone grafts over a 6-month interval and provided comparative biomechanical and histomorphometric data on spinal interbody fusion techniques.

Animals↗
PubMed1987

Cervical cord compression from ossification of the posterior longitudinal ligament in non-orientals.

We report 14 cases of symptomatic ossification of the posterior longitudinal ligament (OPLL) diagnosed in non-oriental men between 1978 and 1985. All 14 patients had incomplete spinal cord syndromes due to OPLL in the cervical spine and had been referred undiagnosed from other institutions. Twelve had severe myelopathy and seven were wheelchair-bound before OPLL was diagnosed, while six patients had had operations elsewhere for their neurological dysfunction. There was a close association between OPLL and diffuse idiopathic skeletal hyperostosis (Forestier's disease) on plain radiographs, seven patients having both disorders. Enhanced CT scans proved to be the best diagnostic method for the localisation of cord compression, and magnetic resonance imaging, used on four recent cases, provided the best visualisation of the extent of involvement in the sagittal plane. We aim to heighten awareness of OPLL in non-orientals, in whom the clinical features, histological characteristics, and radiographic patterns are very similar to those of oriental patients.

Adult↗
PubMed1980

Influence of fructose on the glycogen synthase and phosphorylase systems in rat liver.

Fructose and glucose, when administered as a single, large intravenous dose (500 mg/kg) produced opposite effects on key regulatory enzymes of glycogen metabolism in intact normal fed animals. Glucose rapidly stimulated glycogen synthase phosphatase activity and increased the proportion of glycogen synthase in the active (I) form as expected; fructose reduced synthase phosphatase activity and the proportion of synthase in the I form. Glucose also stimulated a reduction in the proportion of phosphorylase in the active (a) form, whereas fructose stimulated an increase in the proportion of phosphorylase in thea form. The effect of fructose was not mediated by an increase in cyclic adenylate (cAMP) concentration nor by a conversion of phosphorylase kinase b to phosphorylase kinase a. As expected, the concentration of ATP decreased significantly. The increase in proportion of phosphorylase in the a form may be due to stimulation of phosphorylase kinase b activity by a decrease in the intracellular ATP:Mg++ ratio or by increase in intracellular Ca++ concentration. The mechanism of the fructose-induced change in synthase phosphatase activity and in synthase I activity is unknown.

Animals↗
PubMed1974

Valediction.

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Minnesota↗