PubMed HealthSearch

Biomedical subjects

J J Sanders

Publications and source records attributed to J J Sanders.

8 recordsLinked to original sources

Clinical evaluation of freeze-dried bone allografts in periodontal osseous defects. Part III. Composite freeze-dried bone allografts with and without autogenous bone grafts.

Freeze-dried bone allografts (FDBAs) were evaluated alone and in combination with various types of autogenous bone in the treatment of periodontal osseous defects. A total of 381 defects were evaluated by surgical reentry approximately 1 year after grafting. Reentry data were compared with similar data obtained when the grafts were placed. Osseous regeneration and pocket reduction were rated as complete, greater than 50%, less than 50%, or failed. Complete or greater than 50% regeneration was considered successful. When compared with FDBAs, composite freeze-dried bone allografts/autogenous bone grafts (FDBA/ABGs) appear to offer significantly improved results in both osseous regeneration and pocket reduction. Use of composite FDBA/ABGs resulted in significant improvement in the treatment of combination one/two-wall defects and furcation involvements. A trend of improvement was seen with two-wall defects. The surgical data indicated that complete wound closure and the use of antibiotics enhanced graft success. The results also indicated that the presence of endodontically obturated teeth may be a consideration in the success or failure of the graft.

Adolescent

Internuclear ophthalmoplegia and associated abnormalities in eye motion timing (differential delays).

Studies of the dynamic characteristics of horizontal saccadic eye motion give velocity, acceleration, and timing information. Average time differences between the motion of the eyes on left and right gaze, termed "differential delays," are statistical measures of the average differences of right-going and left-going velocity waveforms, and can be determined to within 0.5 msec. These relative time measurements give information that is not necessarily apparent from the velocity or acceleration data, and provide a sensitive measure of early oculomotor dysfunction. Patients with internuclear ophthalmoplegia have been shown to give characteristic abnormal values, and two such patients are described in detail to illustrate how these measurements may be used both to help in diagnosis and to characterize the presumed lesions.

Adult

A new method of cone electroretinography: the rapid random flash response.

A new procedure is described for cone electroretinography using a cross-correlation method of signal processing to give the response to flash stimuli which occur at randomly timed intervals. The output waveform is different than the usual repetitive flicker response, and can be presented on any desired time base. An unfamiliar aspect of this process is that most of the random time intervals between consecutive stimuli are shorter in duration than the output waveform. For the parameters described, the output waveform gives the response to approximately 1,640 stimuli in 65.5 sec., with a signal-to-noise ratio which is higher than that obtained when conventional averaging techniques are used over similar time periods. This allows more precise and statistically significant estimates to be made of the time and amplitude parameters of the cone response. Normal values are given for implicit (delay) time and amplitude, and examples are provided for comparison of the random flash response and conventional average electroretinograms (ERG's) in normal subjects and patients with retinal degeneration.

Adult