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J J Sicilia

Publications and source records attributed to J J Sicilia.

18 recordsLinked to original sources
PubMed2001

Giant cell arteritis and renal amyloidosis: report of a case.

Polymyalgia rheumatica and giant cell arteritis are rarely associated with renal diseases such as amyloidosis. Here is a case of a 72-year-old man, who developed some renal failure and a nephrotic syndrome while presenting clinical symptoms of giant cell arteritis. Percutaneous renal biopsy showed secondary amyloidosis, and temporal artery biopsy revealed some lesions which suggested temporal arteritis. In spite of aggressive steroid treatment, chlorambucil, and colchicine, the patient's renal function continued to deteriorate and the patient is now being given hemodyalisis.

Aged↗
PubMed1980

Red-cell 2,3-diphosphoglycerate in patients with hyperthryoidism.

In 21 hyperthyroid female patients studied on 29 occasions, high levels of red-cell 2,3-diphosphoglycerate (2,3-DPG) have been found (5.75 +/- 0.7 mM) which, compared to a euthyroid control group (4.88 +/- 0.4 mM), could not be accounted for by differences in haematocrit, haemoglobin or phosphataemia. A significant correlation was found (P less than 0.05) between serum thyroid hormones and the 2,3-DPG concentration in the hyperthyroid patients. Eight of these patients were reexamined after treatment and normalization of thyroid function, showed a regression to normal 2,3-DPG values (4.81 +/- 0.6 mM) which could not be attributed to variations in haematocrit, haemoglobin or phosphataemia either. We therefore deduce that the shift to the right in the haemoglobin oxygen dissociation curve observed in patients of this type may be due to an increase in the red-cell 2,3-DPG content.

Adolescent↗