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Biomedical subjects

J J Sienra Monge

Publications and source records attributed to J J Sienra Monge.

At least 19 recordsLinked to original sources
PubMed1995

[Asthma and pregnancy].

Asthma is among the diseases that may complicate pregnancy. Asthma affects up to 4% of the pregnant women. Uncontrolled asthma may impair the proper oxygenation of both mother and child. According to asthma severity clinical manifestations may be unapparent or apparent requiring hospital treatment. It is necessary that pregnant asthmatic woman check daily the peak-flow by portable peak-flow meters. The asthma pharmacological treatment should consider the changes in the physiology of the pregnancy, such as low albumin and carrier proteins for the drugs inducing high levels of free active drugs. This point is important for theophylline, besides the low drug clearance. Bronchodilator should be used as they are required, using the inhaled forms, as well as short term corticoid courses. The goal of the treatment is to control the symptoms, avoid relapse and keep the ventilatory function close to the normal, in order to achieve a satisfactory state of the mother and the children.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Air flow measurement in children with mite allergies before and after skin prick test].

OBJECTIVE: To determine the obstruction of the air flow by flujimetry subsequent to the application of tests cutaneous specific (Dermatophagoides pteronisinnus) in sensitive children. MATERIAL AND METHODS: They were studied 44 patient of one and other sex with diagnostic of asthma and antecedent of sensibility to the mite Dermatophagoides pteronisinnus through tests cutaneous for prick, with an average age of 6 to 16 years, captured of the external consult of the allergy service of the Hospital Infantil de Mexico Federico Gómez. It is a longitudinal study, prospective, blind, cross, in the one which previously was made a challenge test with antigen standardized of Dermatophagoides pteronisinnus or glycerine, previous reading of flujimetry. RESULTS: Of the patients challenged with antigen in 23 there was decrease of the respiratory maximum flow, with a p < 0.05, but without clinical meaning. When they were challenged with placebo only it reduced in patient seven the respiratory maximum flow, also significative statistically, but without clinic relevancy. CONCLUSION: The cutaneous tests are a useful tool in allergy and sure, since almost they do not produce serious systemic reactions.

Adolescent↗
PubMedDate not supplied

[Wheezing in infants].

The wheeze are a common symptom in nursing, especially when suffer infections of the respiratory tract. They are common in 75 to 85% of the children, who have wheezes during some stage of their development between 2 to 5 years old. They can be related to smoking motherly during the pregnancy, exposition to the smoke of the tobacco to the subsequent stage to the birth, exposition to environmental and certain factor infections veers them. The wheezes in patient with atopy maybe they are related to a IgE two standard deviations up above of what is normal and persist as asthma in late stages. The wheeze is an affection syndromatic therefore it is obligatory to seek the factor unfetter you to arrive to a definitive diagnosis.

Humans↗
PubMedDate not supplied

[Determination of immediate hypersensitivity to pollen in allergic patients in the Federal District].

AIMS: The immediate hypersensibility immediate mediated by IgE represents the damage mechanism type 1 according to the original classification of Gell & Coombs. MATERIAL AND METHOD: Observational study, descriptive, transverse in the one which were checked the files of 1250 patient of the Allergy Service of the Hospital Infantil de Mexico Federico Gomez with diagnostic of rhinitis allergic; asthma; asthma and rhinitis allergic. RESULTS: 1250 patient studied 468 were of the feminine sex (37.44%) and 782 (62.58%) of the masculine with a mean age in either case of 7.9 +/- 3.5 SD. With respect to result of cutaneous test 154 (12.32%) were negative and 1096 (87.68%) were positive to one or more antigens. CONCLUSIONS: The obtained results indicate the importance of accomplishing greater number of studies that relate not only the percentages of positive in the determination of immediate hypersensitive, but also to the frequency of pollens in the means to the one which is unfolded the patient, together with the stages of pollination throughout the Mexican Republic, in pediatric population as well as in adult, to effect cutaneous tests selects according to the zone and to stablish a specific treatment and adapted for each patient.

Asthma↗
PubMedDate not supplied

[Degree and duration of bronchodilatation with an agonist beta 2 administered alone versus an agonist beta 2 administered with ipratropium bromide in children with acute asthma].

BACKGROUND: The asthma is the chronic illness of the most frequent respiratory tract of the pediatric age. MATERIAL AND METHOD: Prospective study, longitudinal, double blind, at random with 40 patient (split into two groups) with asthmatic crisis with ages of 8 to 15 years. To all was them accomplished tests of effected pulmonary function of basal way and subsequent to the inhalation of the medication. The medication were administered in two inhalations by three steps and with intervals of 10 minutes between each dose. It was considered that the treatment was effective if the improvement of the pulmonary function tests (VEF1) were presenting an increase of the 15% of their initial value. RESULTS: For each one of the tests accomplished in the different times were found meaningful increases in VEF1 (p < 0.05) in both groups compared with the basal and stayed meaningful until eight hours after the administration of both therapeutic plans. CONCLUSION: The bronchodilator effect of the salbutamol alone and in combination with bromide of ipratropio is similar in intensity and in action time demonstrated by the VEF1.

Acute Disease↗
PubMedDate not supplied

[Procedure for bronchodynamic tests with inhaled allergens].

The asthma is one of the most frequent chronic illnesses in the children. It is characterized by hyperreactivity from the air roads to inspecific stimuli (metacholin and histamin) and specific (allergens). The broncodynamics tests determines the broncolability asthmatic boy's and they help to settle down the I diagnose functional. They should be carried out with antigenic extracts of high quality, lyophilized watery and standardized; you can use an open or closed circuit and a dosimeter, the initial dose of the allergen it is lower than with the one that the positive cutaneous reactivity was obtained, carrying out successive increments until the VEF-1 descend 15% or more. The patient's security is fundamental, they should be carried out for specialized personnel.

Administration, Inhalation↗
PubMedDate not supplied

[Effect of heating on FEV-1 in children with asthma challenged with exercise].

AIMS: The exercise-induced bronchoespasm, also called asthma for exercise, it corresponds to a frequent clinical entity that commonly accompanies the asthmatic patient. Their frequency is of around the 80 to 90% for the patients with asthma; it is presented among 40 to 50% of the children with allergic rhinitis, in the athletes 14% and in the population's 12% in general. OBJECTIVE: To determine the effectiveness of a heating routine like preventive agent of the exercise-induced bronchoespasm. METHOD: 30 patients were included of between 10 and 16 years of age, asthmatic and with exercise-induced bronchoespasm by diagnosed by means of challenge test to the exercise. All the patients carried out an exercise routine with duration of 20 minutes during which movements of elasticity, calisthenics and light activity were made directed to the exercise to develop, taking as objective parameter 60% of the frequency heart submax. Did all the patients carry out challenge at once, again to the exercise, in which a band numberless was used, with speeds that were increased progressively from 1 to 8 km/h and with inclination of 0? 10 0. The spirometrics registrations was made before the challenge and at the 2, 5, 10, 15, 20, 25, 30 and 60 minutes after the same one. RESULTS: The average of the patient's age was of 12.8 +/- 2 years with size of 157 +/- 10 cm. CONCLUSION: The heating in children with broncoespasmo induced by exercise acts as a protective agent against the decrement of the VEF-1. Although the heating can be a good control method in the asthmatic patient, it is necessary to keep in mind that not all the patients have a benefit of this protection. This can only be used in patient with programmed physical activity, since in the preschoolers it is not possible to implant a heating routine for the characteristics characteristic of their activity.

Adolescent↗
PubMedDate not supplied

[Immediate reaction to latex: comparison between skin test and IgE determination with ELISA].

BACKGROUND: Development of latex hypersensitivity type 1 response mediated by IgE depends on exposition intensitivity and genetic predisposition. Clinical manifestations are urticaria, rhinoconjunctivitis, asthma and anaphylaxis. OBJECTIVE: The aim of the study was to determine the frequency of latex immediate skin reactivity on allergy patients from 1-15 yr old from Hospital Infantil de México. METHODS: A clinical, prospective trial was performed between november 1998 and april 1999. During the study we documented 629 patients with allergy. Of them 30 had positive skin prick test (SPT) to latex according to Aas classification and 30 with negative SPT were randomly chosen as control group. Both groups were similar with respect to diagnosis, age, and sex characteristics. RESULTS: 629 children's with SPT, 30 had positive skin princk test (4.76%), 15 men and 15 women, with an average age of 8.9 years. For groups 1-5 years of age. The group age 6-10 years 6.21% and that of age 11-15 8.9%. Atopia antecedent 73.3%. For rhinitis and asthma diagnostic 63%, rhinitis 13%, asthma 20%, conjunctivitis 20%, atopic dermatitis and anaphylaxis 3.3%, urticaria 6.6%. Surgery antecedent 30%. 100% used a sucking, 93% used a latex toy the relationship of symptoms with the use of latex was 6.6%. Statistica1 ana1ysis was performed using: Nonparametric correlations the Kendall's tau-b: 0.329 and Spearman's rho 0.348 correlation is significant. CONCLUSION: It does exist a correlation between SPT and test for latex-especific IgE antibodies, the older the patient, the higher frequency of latex reaction, history of atopy is the mayor risk factor.

Adolescent↗
PubMedDate not supplied

[Desensitization to human recombinant DNA insulin in an adolescent with insulin-dependent diabetes mellitus].

BACKGROUND: Adverse reactions to drugs have increased in the last years, about 15% of all side effects are thought to be immune mediated according to the Coombs and Gell classification they can be type I (immediate) hypersensitivity, type II (cytotoxic) type III (immune complex mediated) or type IV (delay). Allergy to insulin is defined as an immunological response type I, and type II or III to exogenous insulin solutions occurring the 0.1% and 0.2% of the patients. PATIENTS: A 13 year old female with a 4-year history of insulin-dependent diabetes mellitus who presented hypersensitivity against recombinant DNA (rDNA) insulin manifested with urticaria and itching. We used a premedication therapy without good response and impossibility to use alternative therapy for her metabolic control, so she needed desensitization with insulin. METHODS: Skin prick testing with rapid insulin preparations 1:10 W/V dilution were positive. IgE antibodies to insulin weren't presented. IgE serum values were normal. We began the desensitization with a rapid 1:1000 UI insulin solution by intradermal route, than by subcutaneous route until reaching the accumulated doses necessary per day. During the process it appeared a papular rash and itching which were treated with an intravenous antihistaminic without troubles. RESULTS: The patient tolerated the desensitization procedure very well. For the past 14 months she has been treated uneventfully by subcutaneous administration of rDNA insulin. DISCUSSION: The desensitization against drugs is not a frequently process it only has to be used when it is impossible to substitute the treatment. Our patient showed probably hypersensitivity type 1 to insulin. However, we have to take into account the cytotoxic reaction caused by IgG or IgM antibodies or by immune complex. The desensitization finally was tolerated, 14 months after our patient accepts correctly her daily dose of human recombinant insulin.

Adolescent↗
PubMedDate not supplied

[Skin reactivity in allergic conjunctivitis].

Allergic conjunctivitis is a very common disease in our country. We intend to determine the most frequent ocular involvement and the specific sensitivity to common aeroallergens. A longitudinal prospective study was performed on 20 patients from the allergy/immunology and ophthalmology outpatient service, Hospital Infantil de Mexico Federico Gomez, from May to July 1990. All of them had allergic conjunctivitis and were evaluated for ocular involvement and reactivity to common aeroallergens by skin prick test.

Adolescent↗
PubMedDate not supplied

[Correlation of the degree of bronchial hyperreactivity and the intensity and onset of symptoms in asthmatic children].

We studied 51 children with stable bronchial asthma, we did a challenge with methacholine in different dilution until we found their PD20. Once we have it, we correlate this results with the age of onset of asthma and the severity of the symptoms. The results shows that if the symptoms start early in the life had more severe asthma and the PD20 is lower, this means that they have more hyperreactivity. Our results are similar to those found in the literature.

Adolescent↗
PubMedDate not supplied

[Skin response to the allergen of the roach in allergic patients].

Cockroach is an insect that is very frequent in urban areas. There are many research in the last years who shows the relationship between positive prick test to cockroach and respiratory allergy. We made a retrospective study with patient of the out patient clinic of allergy during July to December 1989, and who had a skin test to cockroach. We found a 27% positivities in the skin test, and most of the patients came from the urban area. The positivity of cockroach and dust mite were present in almost 80% of the patients.

Adolescent↗
PubMedDate not supplied

[Use of sodium cromoglycate in nebulizations for asthmatic children less than 7 years of age].

One of the new ways to treat the inter crisis of asthma, is the use of Cromolyn (SCG) in spray or in Rothaller and it's necessary that the patient help's in the cooperation to use this medication. Now with SCG in solution to nebulizer is easy to use this medication in young children. We studied 18 boys and girls in 5 different cities of the mexican Republic, all the patient were younger than 7 years old and had asthma, they received 20 mg. of SCG in nebulizer 4 time daily up to 12 weeks. At the end of the study we found that the symptoms and the use of symptomatic medication were reduce in important way with statistic significance. We conclude the use SCG in nebulizer is safety and efficacy to treat patient with chronic asthma.

Administration, Inhalation↗
PubMedDate not supplied

[Correlation of the degree of bronchial hyperreactivity and intensity and onset of symptoms in asthmatic children].

We studied 51 children with stable bronchial asthma, we did a challenge with methacholine in different dilution until we found their PD20. Once we have it, we correlate this results with the age of onset of asthma and the severity of the symptoms. The results shows that if the symptoms start early in the life had more severe asthma and the PD20 is lower this means that they have more hyperreactivity. Our results are similar to those found in the literature.

Adolescent↗
PubMedDate not supplied

[Effect of cigarette smoke on the airway of asthmatic children].

A study was carried out on 62 asthmatic children for observed the acute effects of one hour of passive cigarette smoking on pulmonary function test before and after 1-hour exposure. Three parameters were measured: Forced vital capacity (FVC), Forced expiratory volume in one second (FEV 1), and Mid-Maximum expiratory flow rate (MMEF). Of those measurement MMEF showed the most important changed in 23% of patients. Passive smoking produced changed on 32.2% on asthmatic patients in any of pulmonary function test. Finally, correlation were made between parental cigarette smoking habits and skin test sensitivity at tobacco antigen, we didn't found correlation between this parameters.

Adolescent↗
PubMedDate not supplied

[Skin tests for different species of acari in asthmatic children from Mexico City].

House dust mites, Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) are the predominant cause of allergic asthma in our population. To detect the presence of sensitivity to other mites besides Dp and Df in 100 children that live in Mexico City, skin tests were performed in their arms with Multi-test devices and glycerinated extracts. There were 34 female and 66 male, aged 4 to 14 years (x = 9.1y), with history of mild and moderate asthma, 2 months to 12 years of evolution. Dp was positive in 96, Df in 80, Euroglyphus maynei in 41, Chortoglyphus in 22, Blomia tropicalis in 17, Trophagus putrescentiae in 12, Glycphagus in 12, Acarus siro in 7, Lepidoglyphus destructor in 7 and Gophieria in 7. Hypersensitivity to all of th species was common. Even we know about the cross-reactivity between them, there are species-specific allergens that could make some of them important in diagnosis and treatment.

Adolescent↗