Biomedical subjects
Publications and source records attributed to J J Stagnone.
Superficial peeling involves the topical use of mild exfoliating chemicals to rejuvenate actinically damaged facial skin and to treat acne, pigmentary disturbances, fine wrinkling, and superficial scarring. Some of the chemicals that can be used and the various techniques employed are discussed.
Phenol and trichloracetic acid (TCA) are used for cosmetic face peeling. Deaths associated with phenol have been ascribed to the cardiotoxicity. Our purpose has been to study and compare the cardiovascular responses to these two agents in a rat model. Fifteen rats underwent abdominal epilation. Two to six days later a surface area comparable to the human face (16 cm2) was delineated on the abdomen. Baker's phenol or 50% TCA was applied to this area. Cardiac rate and rhythm and arterial pressure were monitored. Once stable, the same agent was applied to the entire abdomen for further study. TCA has been shown to be a safer agent than phenol in this rat model. Assuming that this model simulates the human response, monitoring would appear to be indicated during full-face Baker's phenol peeling.
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Two patients are described, each of whom developed multiple eruptive lesions on sun-exposed areas within days after starting benoxaprofen therapy. The lesions were 2- to 5-mm papules suggestive of syringomas, and microscopically showed squamous metaplasia of eccrine ducts and focal necrosis of eccrine keratinocytes as well as prominent eccrine hyperplasia. In both cases, the lesions resolved completely after benoxaprofen therapy was discontinued. A theoretical basis for these findings is discussed.
Chemabrasion is reviewed as a single procedure in which a deep, full-face chemical peel is followed immediately by dermabrasion. In the past few years new information has encouraged some individualization of the chemical aspects of this procedure. A discussion of some factors to consider in selecting chemical agents and our recommendations based on over 5 years of experience are included. In addition, we present some useful refinements of the chemabrasion procedure.
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Chemabrasion was coined to designate a simple, single procedure in which a deep, full-face chemical peeling is followed immediately by dermabrasion. The procedure detailed differs from other techniques in which chemical peeling and dermabrasion are practised together. Certain advantages over chemical peeling and dermabrasion used singly or together in different areas of the face are pointed out. In an early observation of results after a one-year follow-up, it is the author's opinion that the combined procedure yields the benefits of chemical peeling and dermabrasion without increasing the complications of either.