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Biomedical subjects

J J Sziklas

Publications and source records attributed to J J Sziklas.

15 recordsLinked to original sources
PubMed1979

Decreased splenic perfusion without functional asplenia.

Although functional asplenia may be associated with decreased splenic perfusion, two cases are presented which illustrate that the converse is not necessarily true. That is, two patients with markedly reduced splenic perfusion still showed splenic extraction of radiocolloid. These cases clearly demonstrate the dissociation of splenic blood flow and the radiocolloid extraction processes. Factors which might have contributed to the decreased perfusion are discussed.

Adolescent↗
PubMed1979

Reversible functional asplenia in chronic aggressive hepatitis.

A 61-year-old man presented with aggressive hepatitis. Howell-Jolly bodies were present in circulating erythrocytes and the spleen failed to accumulate intravenously administered Tc-99 m sulfur colloid. The patient thus demonstrated functional asplenia. He was treated with high doses of steroids. Four years later, Howell-Jolly bodies were no longer present in circulating erythrocytes. In addition, the spleen had regained the ability to accumulate intravenously injected radiocolloid. Hence, the patient had reversed his functional asplenia. The reported cases of this disorder (reversible functional asplenia) were reviewed and a preliminary classification was proposed.

Colloids↗
PubMed1979

Diverse bone scan abnormalitites in "shin splints".

Four young patients who presented with pain over the anterior compartment of the legs, gave a recent athletic history suggesting stress fractures. Although radiographs were initially normal in all four cases, the bone scintigrams were positive. The individual findings, however, were quite different. In one there was a single focal area of increased radioactivity in each of the tibias; the second patient had uneven uptake of radiotracer and several foci of accumulation in the fibulas; the third showed diffuse linear tibial uptake suggesting periosteal lesions; and the fourth case revealed uptake in the lateral malleolus and in bones of the foot.

Athletic Injuries↗
PubMed1978

Causes and temporal sequence of onset of functional asplenia in adults.

To determine the causes and time course of onset of functional asplenia in adults, a four-part investigation was conducted. This consisted of a review of the world's literature, a survey of colleagues, a detailed study of 4,476 consecutive liver-spleen scans in three hospitals, and continued monitoring of 3,500 scans in five hospitals. Based on the findings, a classification was proposed of the causes of functional asplenia. The two major etiologies were circulatory disturbances and effects directly on splenic reticuloendothelial cells. The time course varied from the essentially instantaneous onset of functional asplenia in patients with acute splenic artery obstruction, to a prolonged and gradual onset in those with chronic damage to splenic reticuloendothelial cells. Functional asplenia was found in 0.14% of the adults who had liver-spleen scans for other indications.

Adult↗
PubMed1978

Pseudo-Budd-Chiari syndrome.

A patient with clinical, laboratory, radiographic and scintigraphic findings resembling the Budd-Chiari syndrome is described. However, at autopsy there was no thrombotic occlusion of any of the intrahepatic veins. The right hepatic vein was completely constricted by the hypertrophied left lobe of the liver, and the left hepatic vein was narrowed. We have referred to this clinical entity as the pseudo-Budd-Chiari syndrome. It represents a potentially treatable form of the Budd-Chiari syndrome.

Aged↗
PubMed1978

Computerized double-tracer subtraction scanning with gallium-67 citrate in inflammatory diseases.

A gallium-67/technetium-99m subtraction technique was used with a variable weighting factor. That is, each image was separately set to 100%. Varying amounts of the Tc-99m images were subtracted from those of Ga-67. A total of 95 patients who had radiogallium scanning for suspected inflammatory disease were studied by the subtraction technique. Thirty of these patients had abnormal Tc-99m pyrophosphate bone scans, while 20 had abnormal radiogallium abdominal foci; 45 had defects in liver, spleen, or kidney images. The subtraction technique with variable weighting was highly successful in enhancing hot-spot visibility, and in providing information as to the anatomic location of the defect.

Abscess↗
PubMed1978

Localization of Ga-67 in inflammations in the absence of circulating polymorphonuclear leukocytes.

Two cases are reported in whom there were no circulating polymorphonuclear leukocytes, on peripheral blood smears, at the time when Ga-67 citrate studies were carried out. In both of these women, Ga-67 accumulated at sites of inflammation. This shows that nonpolymorphonuclear pathways are sufficient to deliver Ga-67 and to allow its accumulation. The possible roles of lymphocytes or of noncellular pathways (such as transferrin to tissue lactoferrin) are mentioned.

Abscess↗
PubMed1975

99m-to-polyphosphate bone imaging in Legg-Perthes disease.

99m-Tc--polyphosphate bone imaging was useful in distinguishing Legg-Perthes disease from other childhood hip disorders in 40 patients. In 33 Legg-Perthes patients, imaging provided earlier and more accurate information concerning the extent of the necrotic and revascularization process involving the hip than radiographs alone. This advantage could both facilitate treatment selection and provide a more objective baseline from which to judge treatment results. Preliminary experience also suggests that the technique may offer some insight into the pathogenesis of Legg-Perthes disease.

Child↗
PubMed1975

Hepatic artery-portal vein fistula detected on hepatic flow study: case report.

A man with a history of gunshot wounds presented with jaundice and a bruit over the upper abdomen. The radionuclide flow sequence revealed simultaneous perfusion of the liver with transit of the activity down the aorta. The was considered compatible with a fistula between the hepatic artery artery and portal vein (confirmed angiographically and at autopsy). An expanding aneurysm of the hepatic artery produced an enlarging focal parenchymal defect.

Arteriovenous Fistula↗