Biomedical subjects

J J Tai

Publications and source records attributed to J J Tai.

22 records · Page 2Linked to original sources

PubMed1989

Asymptotic distribution of the lod score for familial data.

Using a linkage model with mixed parental mating types between a trait locus and a marker locus the asymptotic null distribution of the statistic U = 2ln(10)Z(theta) was stimulated and compared to the chi square type distribution function 1/2 + 1/2 Pr [chi 2(1) less than mu]. The stimulation results show that the chi square approximation fits the asymptotic null distribution well when both loci are predominated by either one of the two alleles at their loci, respectively, or the linkage phase tends to disequilibrium.

Genetic Linkage↗

PubMed1986

Analysis of linkage with disease-marker association.

This paper proposes a method to deal with linkage analysis under the existence of association between a disease and a marker locus. We specially consider the disease as a quantitative trait. At first, we propose a so-called "a minimum sum of square errors approach" to classify individuals in a family genetically, then use the classification results to detect linkage with association by the developed method.

Genetic Diseases, Inborn↗

PubMed1983

Effect of hyperbaric oxygen on GABA transport in rat brain synaptosomes.

Initial velocities of uptake of GABA have been measured in rat brain synaptosomes from animals which had been exposed to oxygen at high pressure (OHP) and compared to similar measurements in normobaric controls. For hypothalamus, no changes in GABA uptake occurred subsequent to exposure to OHP. For cortical synaptosomes, however, exposure to OHP resulted in a decreased velocity of GABA uptake at all combinations of [Na] and [GABA] used. The OHP data were found to fit the same transport model as found previously for control data. Thus, OHP exposure did not alter the basic mechanism by which sodium and GABA interact with the carrier in the process of transport. However, the constants which quantitate the model were changed by OHP exposure. As a consequence, the several kinetic parameters which are calculated from the model change in the OHP animals. These kinetic parameters are compared to similar calculations for both normobaric control animals and normobaric aged animals. Although the effects of OHP do not precisely parallel the effects of aging, the alterations in kinetic parameters are in several ways similar in the aged and OHP animals.

Aging↗

PubMedDate not supplied

The significance of body weight change in non-Hodgkins lymphoma.

BACKGROUND: The purpose of this study was to evaluate the effect of weight changes after completion of chemotherapy on the prognosis and survival of patients with intermediate and high grade non-Hodgkin's lymphoma. MATERIALS AND METHODS: A retrospective analysis of data on patients from the TCOG T1488 protocol, a phase II study using CHOP in the treatment of intermediate and high grade lymphoma. From September, 1988 to December 1994, 138 adult patients had complete weight data for analysis. Weight gain in lymphoma patients after therapy significantly correlated with improved survival (Logrank test p = .0031). In patients with initial B symptoms, weight gain after therapy correlated with survival (Logrank test p = .0039), female patients (odds ratio = 6.2) were less likely to gain weight on treatment. CONCLUSION: Weight gain after chemotherapy for lymphoma is a significant positive prognostic factor for survival.

Adult↗