Biomedical subjects

J Jürgens

Publications and source records attributed to J Jürgens.

At least 19 recordsLinked to original sources

PubMed2004

[Perineal sonography: using time modulated 2D-ultrasound in a freehand 3D technique].

AIM: The employment of a new transperineal ultrasound technique, which demonstrates the dynamics of the temporal change in the positions of the urethra and bladder under standardized Valsalva pressure, was evaluated with regards to the possibility of diagnosing and classifying the various types of descension. METHOD: Transperineal ultrasound using a 3 - 5 MHz Curved array transducer was performed on 21 female patients with urinary incontinence. The results were compared with the clinical examinations and the urodynamic measurements. RESULTS: 17 of 21 profiles could be clearly classified as either rotatory or vertical descension types. 2 of the profiles could not be classified due to lack of patient cooperation, and 2 could not be classified due to technical problems. CONCLUSION: This new method allows a safe diagnosis of the descension types in most cases. All dynamics of the examination can be documented.

Diagnosis, Differential↗

PubMed2003

[Do questionnaires for patients improve the diagnosis of craniomandibular dysfunction with chronic facial pain? A patients' questionnaire study from outpatient practice].

PURPOSE: The differential diagnosis of craniomandibular dysfunction (CMD) is of central importance for the therapy and diagnosis of chronic facial pain. Nevertheless, opinions on causes and treatment differ extremely and are sometimes even contradictory. The necessity of obtaining a precise and thorough patient history is indisputable. This raises the question of whether a questionnaire can offer additional information in order to improve the quality of the history, diagnosis and therapy. MATERIAL AND METHODS: From May 1998 until February 1999, 230 patients who received a monoblock were requested to fill out a questionnaire referring to the previous 4-6 weeks, as an addition to the initial diagnostic tests. In 175 cases we were able to repeatedly examine the patient and compare the effects of therapy with the questionnaires. The questionnaire contains 14 visual, 11-step analogue scales, which are to be marked spontaneously and subjectively. The test-retest reliance at 1 week before treatment was r=0.82 ( n=86). The questionnaire requests information on diverse kinds of pain, sensations and findings in the dental, oral, maxillary and facial areas. For evaluation, a summation-score is built. RESULTS: To our surprise, from a total of 175 patients 41.7% ( n=73) indicated their pain exclusively on the questionnaire. The number and frequency of answers indicated CMD. The average score of the patients whose pain was only mentioned on the questionnaire (31.16+/-19.16) was just slightly below the score of patients with additional, verbal pain descriptions (36.49+/-20.79). CONCLUSION: The picture provided by the answers is impressive for the patient, improves compliance and makes diagnosis easier. In the same way, one can document the success of therapy and explore individual outcomes which show a resistance to therapy.

Adolescent↗

PubMed2003

Three-dimensional multiplanar time-motion ultrasound or anatomical M-mode of the fetal heart: a new technique in fetal echocardiography.

OBJECTIVE: To assess the application of a three-dimensional multiplanar rendering technique for examination of the fetal heart. MATERIAL AND METHODS: Free-hand acquisition of a three-dimensional volume was performed without moving or tilting the transducer. While the anatomical plane shows the four cardiac chambers, the two other orthogonal planes show vertical and horizontal time-axis planes as M-mode traces. Because off-line plane positioning is possible on three-dimensional multiplanar reconstruction, M-mode traces can be obtained from different stored cardiac structures independently of the fetal position. Fifty-two women with normal singleton pregnancies at 22-40 weeks underwent transabdominal ultrasound examination and five women with singleton fetuses between 13 and 15 weeks were assessed transvaginally. Clinical application of the echocardiographic technique was tested in a further two fetuses with arrhythmia. RESULTS: Off-line M-mode traces from atrioventricular valve excursions and myocardial contractions were possible in 45/52 (86.5%) cases examined at 22-40 weeks. Among the 32 fetuses in which visualization of the outflow tracts was attempted, M-mode traces of the aortic and pulmonary valves were possible in 22 (68.7%) and 20 (62.5%) cases, respectively. In three of five cases examined transvaginally, M-mode traces could be registered. Both cases with supraventricular extrasystoles (26 and 31 weeks) were easily diagnosed using this technique. CONCLUSION: The new technique presented here enables the easy acquisition of optimal M-mode traces from different fetal heart structures. Based on our promising findings we would recommend that, in the future, three-dimensional multiplanar imaging should not be limited to automatic volume acquisition but should include the free-hand technique.

Echocardiography↗

PubMed2001

[3D-sonography as "2D-M-mode sonography in fetal echocardiography].

AIM: Establishing a technique employing 3D-ultrasound for the echocardiographic examination of foetuses. METHOD: M-mode sonography has reached considerable importance in the detection of arrhythmia as well as pathological changes of the heart valves and contraction disorders of the foetal heart. The variability of the position of the foetus leads to problems typically arising with this method. The ventro-anterior position along the long axis of the foetal heart, being the optimal position for prenatal echocardiography, allows no examination in M-mode because the plane of the valve lies vertically in relation to the direction of the ultrasound. A special appliance of 3D-sonography solves the problem by providing a 2-dimensional examination technique of the heart in M-mode independent of the position of the foetal heart. The method allows simultaneous measurement of the movement of different parts of the myocardium in several different planes. By fixing the position of the applicator (in B-mode) and choosing the 3D-sequence in the "free-hand-mode" one gets a 2-dimensional time-tissue-block which contains all movements in the chosen axis. These "time planes" can be deliberately selected for the examination of different planes in the fixed B-mode image which shows their variations along the time axis. RESULTS: Our study describes the application and evaluation of this examination during pregnancy between the 28th and 40th week. Reliable images of the AV-valves or the aortic valve could be produced in 73% of examinations.

Arrhythmias, Cardiac↗

PubMed2000

[Recommendations for the standardized evaluation and classification of patients with painful temporomandibular disorders].

INTRODUCTION: Due to the considerable degree of variation that exists among care providers with respect to the assessment of patients suffering from painful temporomandibular disorders (TMDs), an interdisciplinary working group for the study of orofacial pain aimed at developing recommendations for the evaluation and diagnostic classification of such patients. METHODS: Following an extensive literature search (computer-based search and handsearch), several working sessions were needed to develop a standardized diagnostic protocol. It was a prerequisite that recommended measures and instruments should have acceptable reliability and validity. Three independent reviewers - well-known experts in the pain field - critically reviewed the contents of our recommendations. RESULTS: A two-axis approach is recommended to assess the somatic and psychosocial parameters of the pain experience. Our concept closely follows the Research Diagnostic Criteria for Temporomandibular Disorders. In addition, we distinguish a minimal, a standard, and an extended evaluation. CONCLUSIONS: The recommendations appear to be useful to enhance the diagnostic quality in the evaluation of patients with painful TMDs.

English Abstract↗

PubMed1998

[Dental trigeminal neuralgia].

INTRODUCTION: Although the majority of patients with recurrent hyperalgesia of the nervus trigeminus may benefit from drug treatment or invasive (thermocoagulation) and other surgical interventions, a minority of patients does not respond to these strategies. Hence, unusual etiologies must be taken into consideration. CASE REPORT: Mrs F., a 74-year-old women suffered from acute left-side trigeminalgia ten days after receiving a new dental prosthesis (upper jaw). Intensive pain attacks occurred spontaneously when she was speaking and could also be evoked by gentle exogenous pressure at the upper lip. INTERVENTION: The painful area has been identified by careful clinical evaluation. Local administration of antibiotics combined with laser coagulation successfully cured the trigeminalgia after 4 weeks which did not recur in the follow-up period over 2 months. CONCLUSION: Since patients longer history revealed pain attacks of minor severity we suggest that local inflammation at the gingiva might have stimulated quiescent nociceptors over time. The local pressure to this area evoked by the new prosthesis seems to be definitive trigger factor to intensify the nociceptor response resulting in higher number of trigeminalgia attacks of marked severity. We therefore conclude that differential diagnosis of symptomatic trigeminalgia should include dental gingival mechanisms at least in a case exhibiting resistances to other treatment.

English Abstract↗

PubMed1996

Syntheses and biological activities of new N1-aryl substituted quinolone antibacterials.

A series of quinolones with a systematically varied substitution at the phenyl ring at N1 has been synthesized. Three lipophilicity descriptors (log K, log P, Rm) and the pKa values have been determined as well as the microbiological activity: The MIC values for eight different strains of three Gram-positive and three Gram-negative species and the inhibitory concentrations of DNA supercoiling (IC90 and IC100) were determined. From a principal component and a QSAR analysis relationships between antibacterial activity concerning the whole-cell system and electronic properties as well as the length of the substituents at the phenyl rings could be derived. The activity in a cell-free system was governed by the lipophilicity and the width of the substituents. It is speculated that the quinolones take a defined place in the DNA gyrase-DNA complex which is characterized by polar amino acids. This is in agreement with findings from studies of mutant gyrases.

4-Quinolones↗

PubMed1994

[Multiple work stations for an ultrasound device].

A possible technical innovation of ultrasound technique could take into consideration the multiple use of the ultrasound system and thereby facilitate the utilisation for the examining physician and the equipment. This innovation is described and discussed in detail in the following essay.

Equipment Design↗

PubMed1994

[Detection of EWS-/FLI-1 gene fusion transcripts by RT-PCR as a tool in the diagnosis of tumors of the Ewing sarcoma group].

Recent cloning of the chromosome breakpoint regions of the reciprocal chromosomal t(11;22) (q24;q12) has revealed that the breakpoints were localized within the EWS gene (Ewings sarcoma gene) on chromosome 22 and the FLI-1 gene on chromosome 11. Thus, molecular genetic techniques were applicable for the detection of this genetic aberration, which occurs as a consistent feature of the Ewings tumor family. By reverse transcription and polymerase chain reaction technique (RT-PCR) in 78% of Ewings sarcoma derived cell lines, and in 91% of primary Ewings tumor tissue t(11;22) specific EWS/FLI-1 fusion transcripts were detected. Furthermore, in bone marrow samples from an Ewings sarcoma patient contaminating tumor cells could be shown by RT-PCR. Our results indicate that molecular genetic detection of the t(11;22) translocation opens a new modality for the differential diagnosis and the staging of Ewings tumor patients.

Base Sequence↗

PubMed1988