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Biomedical subjects

J Jacques

Publications and source records attributed to J Jacques.

9 recordsLinked to original sources
PubMed1979

Localized primary tumors of the pleura: an analysis of 40 cases.

A study of 40 localized primary tumors of the pleura in the files of the Canadian Tumour Reference Centre revealed a considerable diversity in their histologic structure. Collagenized, hemangiopericytoma-like and cellular areas were the main forms of growth pattern, with half of the tumors showing a mixture of two or more of these elements. Inclusions of non-neoplastic bronchioloalveolar epithelium were frequently seen in areas of tumor adjacent to lung substance but in only one tumor was there a neoplastic component of epithelial form. Eight tumors (20%) showed evidence of malignant behavior. All of these were large and cellular at the time of initial surgery and four had mitotic counts of 10 or more/10 H.P.F. in areas. The evidence suggests that the great majority of localized pleural tumors arise from submesothelial mesenchymal elements and it is believed that the term mesothelioma should not be used in reference to these growths.

Adult↗
PubMed1979

Benign clear cell tumor of the lung.

Light microscopy of a benign clear cell tumor of the lung showed considerable central necrosis, making the differential diagnosis from metastatic clear cell tumor of the kidney difficult. Nevertheless, distinguishing features were seen on both light and electron microscopy that helped make this important distinction.

Adenocarcinoma↗
PubMed1978

Antiinflammatory and analgesic diastereoisomeric derivatives of indan-5-acetic acid.

Various 2-alkyl-alpha-methyl- and 2-alkylindan-5-acetic acids have been prepared. The acids, which can exist in two diastereoisomeric forms that cannot be separated by crystallization or chromatography, can be analyzed in their mixture by NMR in the presence of Eu(dpm)3. It has been possible to reconstitute the two pure racemic 2-isopropyl-alpha-methylindan-5-acetic acids from their enantiomers obtained after resolution of the mixtures through salts with various active bases. The relative configuration of the two asymmetric centers of one of the diastereoisomers salts with various active bases. The relative configuration of the two asymmetric centers of one of the diastereoisomers has been determined by X-ray crystallography. The absolute configurations of the resolved acids have been established by a comparative study of their CD curves. The antiinflammatory and analgesic properties of these compounds as functions of their structure and stereochemistry are discussed.

Animals↗
PubMed1977

Bronchiolo-alveolar carcinoma: a Clara cell tumor?

The cell of origin, and indeed the very existence, of bronchiolo-alveolar carcinoma have long been the subject of debate. Published cases have demonstrated the presence of type II pneumocytes in some tumors, while others have been composed of mucus-secreting bronchiolar cells. A case of bronchiolo-alveolar carcinoma is presented in which the ultrastructure indicates an origin from Clara cells, but in which some cells contain polymorphous and lamellar bodies, It is concluded that bronchiolo-alveolar carcinoma is a primary lung tumor derived from the terminal airways and in the majority of cases from the bronchiole. The value of electron microscopy in assessing such tumors is emphasized.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1976

Xerophthalmia and measles in Kenya.

In many African countries measles is considered to be an important cause of blindness. On the basis of his observations in Kenya and Tanzania in 1972 Franken presumed, however, that in the majority of these cases xerophthalmia was the real cause of blindness, precipitated by the "catalyst" measles. In order to gain a better understanding of this important complicated problem, we performed in the first half of 1974 an investigation in Kenya into the prevalence of xerophthalmia. In December 1974 we had the opportunity to evaluate our Kenyan findings on Java, in the company of Dr. J. ten Doesschate and Professor H.A.P.C. Oomen. The results of this investigation in Kenya and Indonesia are presented in this thesis. (see article) 1. Xerophthalmia occurred nearly everywhere in Kenya in 1974. This demonstrates the prevalence of xerophthalmia in communities which - do not have rice but - have maize for their staplefood. 2. Xerophthalmia appears to be the main cause of blindness in Kenyan children. 3. Measles often plays - by means of local and general "catalysing" effects - an important role in the development of blindness caused by xerophthalmia. 4. In well-nourished children measles is of no consequence as a cause of blindness. 5. Vital staining by 1% rose bengal or 1% lissamine green appears to be a real asset for the early diagnosis of xerophthalmia in Health Centres and in field surveys. This method is therefore of great importance for the prevention of severe, blindness inducing vitamin A deficiency.

Adolescent↗
PubMed1976

Double prosthetic aortic valve. Late aortic erosion by Hufnagel valve.

This is a case report of a patient who had one of the first Hufnagel ball-valve prostheses inserted in 1954 for severe aortic incompetence. He obtained relief of symptoms for 14 years before recurrence necessitated the insertion of a Starr-Edwards valve. The patients was symptom-free for another seven years before the original valve, which had been left in place, caused his death by eroding through the aorta.

Adult↗
PubMed1975

Solitary liver nodules.

There has been confusion in the literature over the nomenclature of solitary liver nodules. Several such lesions have recently been reported in patients taking oral contraceptives. Similarities exist between these cases that suggest they may be examples of focal nodular hyperplasia. Here three further cases are presented. The criteria for making the diagnosis and its importance are discussed.

Adult↗