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Biomedical subjects

J Jaffe

Publications and source records attributed to J Jaffe.

At least 55 records · Page 3Linked to original sources

Timing analysis of coding and articulation processes in dyslexia.

Several investigators have found that the time required to perform serial naming tasks is a good predictor of dyslexia in children. Protracted overall time scores, such as are reported for the Rapid Automatized Naming (RAN) test of Denckla and Rudel, are, by themselves, insufficient to determine the extent to which the performance deficit is cognitive in nature, or is the articulatory consequence of an inability master the quickly changing acoustic formant patterns associated with consonants, as proposed by Tallal. We administered the RAN test to matched groups of dyslexic and normal control children, aged 8 to 11 years. Measurement of speech signal durations was performed by computer. We applied the Gould and Boies algorithm for extracting cognitive preparation time to these data, resulting in a partition of overall RAN test score into coding time and articulation time components. Differential performances between the groups on RAN subtests were examined for effects of postvocalic consonants and semantic load. It was found that both vocalization time and pause time means were significantly longer for the dyslexics on each of the four RAN subtests: objects, colors, numbers, letters. The Gould and Boies analysis showed very little preparation time during speech in both groups, attributing virtually all coding time to pauses, although reanalysis suggested somewhat less. Increased vowel length among the dyslexics occurred on all subtests, but was not maximized on subtests with more numerous postvocalic consonants. Vowel time differences between groups accounted for nearly all of the differences in vocalization time. Profiles were constructed on speech measures which, for each subtest, correctly identified each subject with his group. On the letters subtest it was found that vowel duration alone achieved a perfect discrimination between the dyslexic and control subjects.

Child↗

Neuroendocrine reactivity to nicotine in smokers.

The present study explored neuropeptide responses to nicotine from smoking. Habitual smokers smoked research cigarettes of known strength under controlled laboratory conditions while blood samples were withdrawn unobtrusively for subsequent biochemical analysis. To provide a metric that reflected total nicotine intake and total neurohormonal output, data were integrated over time. Subjects were relatively unresponsive in the low-nicotine (0.48 mg) condition. In the high-nicotine (2.87 mg) condition, there were significant positive correlations between integrated plasma nicotine and plasma arginine vasopressin (r = +0.985), its carrier protein neurophysin I (r = +0.944), and beta-endorphin-beta-lipotropin (r = +0.977), but not adrenocorticotropic hormone. Data from an experiment that used an extraction step to remove beta-lipotropin corroborated the functional relationship between plasma nicotine and beta-endorphin implied by the original findings. Taking into account recent research on the role of neuropeptides in the modulation of affective states and cognitive function as well as of other CNS activity, the present findings were interpreted as strengthening the hypothesis that nicotine-stimulated neuropeptide release provides positive reinforcement for smoking.

Adrenocorticotropic Hormone↗

The effects of LSD-25 and dextroamphetamine on the use of defensive language.

Verified that psychotomimetics attenuate verbal defense mechanisms. This was accomplished by reanalyzing the 5-minute monologues of 7 neurotic depressives who participated in a project (Mechaneck, Feldstein, Dahlberg, & Jaffe, 1968) that examined the effects of LSD and dextroamphetamine on timing aspects of speech. Dosages were subhallucinatory: 15-25 mg dextroamphetamine, 50-100 mg LSD, and a matching placebo. Volunteers received each drug (double-blind) seven or eight times on a random schedule over a 1 1/2-year period; there was a 3-week intertrial interval. The patient provided 5-minute monologues both before and after drug effects. The monologues were transcribed and scored for formal measures of defensive language. Results indicated that LSD caused individuals to make more personal statements and to use explanation and evaluations less often. Dextroamphetamine was found to decrease the use of nonpersonal references.

Adult↗

The effect of psychotomimetics on therapist--patient matching of speech "rhythms".

This study examined the effects of lysergic acid (LSD) and dextroamphetamine (DA) on therapist--patient matching of speech rhythms (mean phrase period) in psychotherapy. LSD, DA, and placebo (PL) were administered repeatedly over a 1 1/2-year period to seven patients in a randomized double-blind design. The second, fourth, and sixth encounters with LSD, DA, and PL were analyzed. These therapy dialogues were processed by an on--off detector of speech which computed probabilities of vocalizing when already talking (T), when listening (L), and when pausing (P) for therapist and patient, respectively. The mean phrase period for the therapist and the patient was calculated from the vocalization probabilities (T, P). The results show that both LSD and DA significantly enhance therapist-patient matching of mean phrase period in the earliest (second) session, an effect that disappears for both drugs, but later for DA (sixth session) than for LSD (fourth session). At no time was this effect observed in PL sessions, nor was the matching a simple function of a therapist--patient convergence of the components (T, P) of the mean phrase period.

Adult↗

Vocal interruptions in dyadic communication as a function of speech and social anxiety.

Interruptions have been defined as a breach of the "turn-taking" contract in interpersonal communication. The relation between a speaker's personality and his or her propensity to interrupt was examined in 30-min unstructured conversations for 36 dyads (12 male, 12 female, and 12 mixed sex). The following predictions were made: (a) Interruptive behavior is inversely related to speech anxiety and positively related to confidence as a speaker; (b) interruptive behavior is inversely related to social anxiety (avoidance-distress; fear of negative evaluation). A stepwise multiple regression analysis was performed, controlling for the systematic effects of sex, the conversational partner's personality and amount of speech, and the speaker's use of back-channel responses. These hypotheses were confirmed for rate of total interruptions and rate of successful interruptions, for percentage of successful interruptions, and for mean duration of interruptions; the results withstood cross-validation analysis.

Adolescent↗

Therapeutic community dropouts: criminal behavior five years after treatment.

Two hundred and two male dropouts, mainly heroin abusers averaging 3 to 6 years out of treatment, were sampled from the 1970-1971 Phoenix House admissions by race and time in program (less than 1 month to more than 2 years). Criminal justice arrest records were compared between three pre- and all posttreatment years. Percent and rate of arrest declined significantly in followup. Magnitude of reductions was uniform across race and legal status, varied by age, but increased systematically by time in program. Results replicated and extended earlier findings, confirming long-term positive change in criminal behavior associated with length of stay in the therapeutic community.

Adult↗

Delta 9-tetrahydrocannibinol: acute efects on defensive and primary-process language.

This study examined the effects of delta 9-tetrahydrocannibinol (THC) on defensive, primary-process, and secondary-process language. Four male volunteers provided 5-minute monologues in three conditions: Round 1,placebo; Round 2, 15 mg THC; Round 3, recovery. THC was found to attenuate defensive language behavior (retractors, qualifiers, direct references) and to increase the use of secondary-process (intellectualizing) vocabulary.

Adult↗

The relationship of defensive language behavior in patient monologues to the course of psychoanalysis.

Examined the relationship of the time-course of psychoanalysis to progressive alteration of defensive language behavior in 7 patients. Spontaneous 5-minute monologues were recorded over 1 1/2 years of three-times-a-week individual psychotherapy. Weintraub and Aronson's (1962) formal measures of defensive language were used: nonpersonal references, negators, qualifiers, retractors, explaining expressions of feeling, and evaluators. The magnitude of defensive speech displayed by a patient was able to predict significantly the duration of psychoanalysis undergone by that patient in 4 of 7 cases.

Affect↗

Malignant papillary mesothelioma of tunica vaginalis testis.

A malignant papillary mesothelioma of the tunica vaginalis testis with retroperitoneal lymph node and pulmonary metastases is reported in a seventy-seven-year-old man. Electron microscopy of a local recurrence documented its mesothelial origin. The clinical and pathologic features of these rare neoplasms are discussed.

Aged↗

Synergistic growth promoting action of L-cysteine and nitrogen upon Hymenolepis diminuta cysticercoids in vitro.

Development in vitro of cysticercoids of the cestode Hymenolepis diminuta in the presence of L-cysteine proceeded twice as rapidly under 100% nitrogen as it did with air as the gas phase. No growth was obtained with the following: D-cysteine, L-cysteine methyl ester, S-aminoethyl cysteine, L-cystine, glutathione (reduced), L-methionine, D-pantothenic acid, taurine, or thioglycolic acid; limited growth only was obtained with ascorbic acid and dithiothreitol. Homocysteine or coenzyme A was as effective as L-cysteine in stimulating the complete development of oncospheres to cysticercoids. Experiments with 14C-L-cysteine indicated that L-cysteine was perhaps incorporated into the organisms.

Animals↗