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Biomedical subjects

J Jagielski

Publications and source records attributed to J Jagielski.

At least 19 recordsLinked to original sources
PubMed1991

[Cytogenetic studies in patients with non-Hodgkin's lymphoma (nHL)].

Cytogenetic examinations were carried out in 24 untreated patients with non-Hodgkin, non-Burkitt lymphoma. 10-20 G-banded metaphases, obtained from short-term cultures of unstimulated lymph++ node, bone marrow and blood cells were analyzed in each case. In 18 patients only, the obtained metaphases were suitable for cytogenetic analysis. In 11 patients (group A) karyotype was normal or only single, +non-clonal aberrations were observed. In 7 patients (group B) clonal aberrations were found, among them, in 3-structural changes of chromosome 1, but with different breakpoints: 1p31, 1p31, 1p36. The group of patients with chromosomal aberrations showed statistically significantly shorter survival time than the group without aberrations (p = 0.04). In the former group more patients had low grade malignancy lymphoma. Our observations confirm those data from the literature which indicate that the presence of chromosomal aberrations is a factor of poor prognosis, independent of other clinical and histopathological prognostic factors in non-Hodgkin Lymphoma.

Adolescent↗
PubMed1990

Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia.

Cytogenetic analyses were carried out on peripheral blood and bone marrow cells of 31 chronic myeloid leukemia (CML) patients who presented with blastic, accelerated, or chronic phases. The percentage of cytoplasmic nonspecific cross-reacting antigen (cNCA, a marker of myelocytic differentiation)-containing cells was determined in the same blood or bone marrow samples. The patients were divided in two groups according to cytogenetic results: those with aberrations in addition to the Philadelphia chromosome (Ph1) and those with Ph1 only. Among the additional aberrations such changes, not typical of CML, were found: del(2)(p21), t(6;11)(q25;q23), and t(12;?)(p13;?). The survival time and the percentage of cNCA-positive cells of patients in blastic and accelerated phases were compared between the above-mentioned two groups of patients using the Student t test and the Kaplan-Meier estimator. The percentage of cNCA-positive cells was significantly lower and the survival time significantly shorter in the group of patients with additional aberrations. The probability of survival according to the Kaplan-Meier estimator was also lower for this group. These data suggest that the immunologically determined lower degree of maturity, that characterized cells bearing additional aberrations, coincides with and/or results in more rapid progression of the disease.

Adult↗
PubMed1990

Genotoxic effects observed in workers occupationally exposed to organic solvents.

The aim of this work is to analyse chromosome aberrations and cell cycle kinetics in workers occupationally exposed to organic solvents, which contain benzene among other agents. In the exposed group structural chromosome aberrations were found in 2%, while in the control group in 0.9% of analysed metaphases. Detailed band localization of breakpoints in chromosomes of patients in both groups is presented. No significant differences in cell cycle kinetics in individual members of exposed and control groups were found.

Adult↗
PubMed1977

[ECG examinations on a PMM model].

The analysis of cardiac electric field interference on rabbits with additional heart implanted to abdominal cavity resulted in explanation of ecg variations during the first hours of newborn's life. The investigation of multipole and multidipole fields in spherical chamber proved that the disturbation of axial symmetry of added up elementary dipoles evokes significant multipole components in the heart.

Animals↗
PubMedDate not supplied

[Localization of infarction of the anterior and inferior myocardial wall by body surface mapping].

11 patients after anterior myocardial infarction and 7 patients inferior myocardial infarction were subjected to potentials mapping from 87 body surface electrode system. The reference group was made up by 15 healthy individuals. The analysis referred to isopotential and isointegral maps during the 20 ms and 40 ms of the QRS onset and for the entire QRS. It was stated that the occurrence of abnormal potential minimum might be the essential diagnostic criterion. In the case of anterior infarction, the abnormal negative potentials is located in the vicinity of the sternum, whereas in inferior infarction in right and lower part of the chest. The diagnostics of inferior infarction requires additional criteria, ventricular activation time maps especially.

Action Potentials↗
PubMedDate not supplied

[Hydrocephalus as a sequel of hemorrhage from ruptured cerebral aneurysm in light of CT investigations].

In the years 1985-1987 CT studies were carried out in 182 patients after haemorrhage from ruptured intracranial aneurysm. The study was carried out before surgery or the patients were not operated on for various reasons. Hydrocephalus was found in 33 cases, that is 18.2%. The patients were divided into subgroups depending on the time of CT after haemorrhage and on the state according the Hunt-Hess classification. Since only a small per cent of cases fell into the I and II categories of the classification, one may state that posthaemorrhagic hydrocephalus is connected usually with worse condition of the patient. Early hydrocephalus was relatively rare. In only a part of the cases CT was done on the first day after haemorrhage and it was difficult to say whether the presence and amount of blood in the basal cisterns and over the convexity contributed significantly to the development of hydrocephalus. However, in half the cases with intraventricular bleeding hydrocephalus was present.

Adult↗
PubMedDate not supplied

[Subarachnoid hemorrhage of unknown etiology].

A group of 73 patients is described in whom diagnostic procedures failed to demonstrate the source of haemorrhage. In this group 92% of patients were in good clinical condition after the episode (I and II clinical group). In only one patient with angiographically demonstrated diffuse vasospasm in one cerebral hemisphere signs of focal brain damage developed leading to death. The remaining 95.9% of patients left the hospital in good condition, without focal signs. During follow-up in two (3.2%) out of 62 patients with known condition a recurrence of subarachnoid haemorrhage developed. Most patients were in good condition, fully fit up to 3 years after the haemorrhage. In summary, the authors stress a mild course of subarachnoid haemorrhage of unknown aetiology, good prognosis as to return of full fitness, and relatively low risk of development of focal brain damage or death from haemorrhage.

Adult↗