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Biomedical subjects

J Jakó

Publications and source records attributed to J Jakó.

At least 19 recordsLinked to original sources
PubMed2001

Identification of P-selectin glycoprotein ligand-1 as a useful marker in acute myeloid leukaemias.

Immunophenotyping is considered to be less valuable in the diagnosis of acute myeloid leukaemias (AML) compared with acute lymphoid leukaemias. Here, we present data on the use of quantitative flow cytometry (QFC) of P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and three-colour immunophenotyping including CD162 staining in the identification of myeloid precursors in AML. Analysis of normal peripheral blood (n = 20) and normal bone marrow (n = 5) samples and on 20 samples from de novo M1, M2, M4 and M5 AML patients demonstrated that PSGL-1 is differentially expressed on various mature and immature leucocyte subsets. It was found by QFC that neutrophils expressed 26500 +/- 4500 and monocytes 47200 +/- 9900 copies of PSGL-1 on their surface, whereas AML blasts from M1 and M2 AML patients expressed significantly less PSGL-1 (12 000 +/- 5300) than mature neutrophils (P < 0.001). In M4 and M5 leukaemias, however, the amount of PSGL-1 on monocytic precursors is displayed in a fairly broad range that is not significantly different from that of mature monocytes (P = 0.084). Using three-colour immunophenotyping PSGL-1-dim staining was co-expressed with CD7 and C34 positivity and PSGL-1 staining intensity on immature myeloid cells paralleled with CD45 expression. This would imply a differential expression of PSGL-1 during myeloid haematopoietic development and suggests that quantification of surface PSGL-1 may aid in differentiating myeloblasts from monoblasts by immunophenotyping in different AML subsets.

Acute Disease↗
PubMed1998

[Current data on familial occurrence of malignant hematologic diseases in the County of Szabolcs-Szatmár-Bereg in Hungary].

So far the authors have observed 27 cases of accumulation of malignant haematologic diseases within a family in their county. They published the first ten cases in Orvosi Hetilap in 1992. Most often the co-existence of the diseases with the highest incidence (non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, acute leukaemia) was observed, in terms of relationship mostly the parent--child combination was observed. Analyzing the data of parent--child combinations (17 cases) they can notice two remarkable trends: 1. The "malignity degree" of the disease appearing in the second generation is either the same or greater than that of the disease of the first generation (the opposite of this was not experienced in any of the cases!). 2. The disease of the second generation appears mostly at a much younger age than that of the parent. Consequently, they can observe a "double acceleration": the disease tends to be more malignant nearly in the half of the second generation patients, and the disease appears in the children at a much younger age.

Adolescent↗
PubMed1996

[Thrombosis in the small branches of the superior mesenteric artery in the early stages of essential thrombocythemia].

A tumour in the large bowel in a 67-year-old female patient was observed for the first time in 1991, and that is why a hemicolectomy was performed. Microscopic examination showed mucosal ulceration with chronic inflammation, but no malignancy was found. Small arteries in the bowel wall were occluded by organized and recanalized trombi. The pathologist thought it could be a rare visceral form of Buerger's disease. Two and a half years later essential thrombocythemia was diagnosed in the patient. On investigating her case-history the authors found that the myeloproliferative disease had already been in its early clinical stage in 1991. So the thrombotic events of the small arteries can be considered as the first sign of essential thrombocythemia. The authors concluded the observation of unusual and unexplained thrombotic events may suggest myeleproliferative disorders, even if their diagnostical criteria are not yet well manifested.

Aged↗
PubMed1994

[Association between malignant hematologic diseases and cancer].

Between January 1 1983 and December 31 1993, 56 cases of association between malignant haematologic diseases and cancers were registered by authors. In their 15 cases there was the first tumour the cancer, in 20 cases the haematologic malignancy, and simultaneous occurrences were found in 21 cases. With the exception of eleven patients the second malignancy was diagnosed (and as far as possible treated) in the life of patients. With the exception of three cases authors experienced the associations of one haematologic malignancy and one cancer. In their seven cases they suggest causal association between the treatment of the first disease and the development of the subsequent malignancy.

Adult↗
PubMed1993

[Obstructive cardiomyopathy, caused by amyloidosis, associated with bone marrow myeloma].

A case of a 40-year-old female is reported. Her symptoms started with abdominal complaints, loss of weight, general weakness, then gradually polyneuropathy, worsening hypotonia and systolic heart murmur developed. The bone marrow showed 20-25% infiltration by myeloma. An IgG lambda type paraproteinaemia was diagnosed using immunelectrophoresis. The ejection systolic murmur was caused by restrictive cardiomyopathy--characteristic of primary amyloidosis--with obstruction of the outflow tract of the left ventricle. Echocardiographic changes took 11 months to develop. The patient's status became dominated by severe hypotonia and she died as a result of heart failure. The post mortem examination confirmed amyloidosis with myeloma. Histopathological examination of the myocardium, coronary and other arteries revealed severe changes with AL-type amyloid deposits. The case demonstrates that amyloidosis can lead not only to restrictive cardiomyopathy but obstruction of the outflow tract of the left ventricle.

Adult↗
PubMed1992

[Cases of familial leukemia-lymphoma in Szabolcs-Szatmár-Bereg County].

Nine cases of familial malignant haematologic diseases were found by authors. Demonstrating the clinical pictures and the developments of nine pairs of cases (Hodgkin's disease--non-Hodgkin's lymphoma, Hodgkin's disease--chronic lymphocytic leukaemia, non-Hodgkin's lymphoma--acute lymphoblastic leukaemia, hairy cell leukaemia--acute lymphoblastic leukaemia, chronic lymphocytic leukaemia--acute myelogenous leukaemia, non-Hodgkin's lymphoma--chronic lymphocytic leukaemia, and three times chronic lymphocytic leukaemia--chronic lymphocytic leukaemia) authors want to give data about occurrences of familial leukaemia/lymphoma in their county.

Adult↗
PubMed1990

[Analysis of the data from the Szabolcs-Szatmár County 1983-1987 leukemia/lymphoma registry].

In Szabolcs-Szatmár county between January 1 1983 and December 31, 1987, 465 new cases of adult malignant haematologic diseases were registered by authors. The authors present the yearly distribution of cases, and analyse the main types and characteristics of the disease entity. According to their data the epidemiology of leukaemia/lymphoma in their county is equivalent to that of European and North American, therefore that may be considered as a standard for their whole country. Their work is date-collecting, it is still going on. Authors want to have more exact informations about epidemiology of leukaemia/lymphoma in their county. Their results have great importance in organizing and continuous assuring of modern treatment of haematologic malignancies. Their data would probably allow to make etiopathogenetic and therapeutic conclusions in a few years.

Humans↗