Biomedical subjects

J Joossens

Publications and source records attributed to J Joossens.

5 recordsLinked to original sources

PubMed2004

Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator.

In this letter we report the synthesis and biochemical evaluation of selective, irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator (uPA). A diphenyl phosphonate group was introduced on the substratelike peptide Z-d-Ser-Ala-Arg, and modification of the guanidine side chain was investigated. A guanylated benzyl group appeared the most promising side chain modification. A k(app) value in the 10(3) M(-1) s(-1) range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.

Benzene Derivatives↗

PubMed1989

The INTERSALT study: main results, conclusions and some implications.

INTERSALT is an epidemiological study of electrolyte excretion and blood pressure in 10,079 men and women from 52 centres and 32 countries. The data were collected according to strict protocol with extensive quality control, and were analysed both in individuals and across centres. In the individual analysis, with adjustment for confounding variables, significant positive associations were observed between blood pressure and twenty-four hour sodium excretion, body mass index and alcohol intake, and significant negative associations between blood pressure and potassium excretion. For a number of reasons, it is likely that the size of these relationships was underestimated. Across centres, linear slope of blood pressure with age was positively related to median sodium excretion. These observations imply that a policy combining changes in sodium and potassium intake with reductions in obesity and alcohol consumption could bring important public health benefits.

Adult↗

PubMed1985

Urological aspects of the Shy-Drager syndrome: a urodynamic and telemetric investigation. Incontinence treatment by electrical pacemaker and prenalterol.

A patient with proven Shy-Drager syndrome underwent a complete urodynamic investigation with telemetry. Unstable bladder and rectum were observed. Therapy with an anal pacemaker and the beta 1 agonist, prenalterol, cured both bladder and fecal incontinence.

Adrenergic beta-Agonists↗

PubMed1979

[Control of incontinence using external electronic stimulators].

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Anal Canal↗

PubMed1977

Frequency analysis of the electromyographic activity in striated pelvic floor muscles: a preliminary report.

A power spectrum of the electromyographic signals in urethral and anal sphincters has been analyzed in 25 patients. Different spectra are observed in each muscle, with higher frequencies in the urethral sphincter. The high frequencies are manifest at short brisk contractions (e.g. cough) and disappear quicly during a sustained voluntary contraction. High frequencies are less pronounced in stress incontinence, but increase in spastic syndromes. The hypothesis is advanced that the proportion of active tonic and phasic motor units determines the efficiency of sphincter reactions.

Action Potentials↗