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Biomedical subjects

J K Beverley

Publications and source records attributed to J K Beverley.

At least 19 recordsLinked to original sources
PubMed1978

Experimental toxoplasmosis in young piglets.

Piglets eight to 10 days old and one day old were infected with a cyst-forming strain of Toxoplasma gondii of low virulence. The older piglets developed an immunological response to the infection and survived, although inflammatory lesions were demonstrable in a variety of tissues. Some of the one-day-old piglets died; they exhibited more severe inflammatory lesions and lymphoid depletion in the lymph nodes, spleen and thymus. The tissue reaction resembled infection with a high-virulence strain of the organism. Control animals showed a delay in maturation of the lymphoid system during the first week of life. The virulence of the organism in therefore modified to a certain extent by the competence of the animal to develop an immunological response to the infection.

Animals↗
PubMed1977

Toxoplasmosis in coypu.

Serological studies indicate that toxoplasmosis is a common infection in coypus now established in Norfolk. A strain of Toxoplasma gondii was isolated from an animal which had shown a high titre to the dye test for toxoplasma antibodies. This was similar to the many tissue cyst producing strains which are of low virulence for most of the small laboratory animals. Congenital toxoplasmosis was proved in a litter born to one of the coypus during captivity. Superinfection occurred when animals, previously infected with a strain of low virulence, were given a challenge of the highly virulent RH strain, but coypus are so resistant that the latter strain caused no apparent illness even in previously uninfected seronegative animals. Antibodies developed to titres of 1:100,000 or more and, at lower levels, persisted for at least a year.

Animals↗
PubMed1977

Experimental toxoplasmosis in calves.

Nine calves were inoculated with tissue cysts of a low virulence strain of Toxoplasma gondii and killed at intervals up to 10 weeks. An immunological response took the form of circulating antibodies and reactive changes in the lymph nodes. The organism could only be recovered from the lymph nodes and this only during the first four weeks after infection. No tissue cysts were demonstrated and only a few inflammatory lesions occurred. Thus, although calves can be infected, the immunological response is prompt with rapid elimination of the organism.

Animals↗
PubMed1977

Nocardia species as a possible cause of ovine abortion.

An instance of ovine abortion is described in which focal placental lesions were caused by a Gram-positive branching filamentous organism. The organism was present in well oxygenated tissues and so is thought more likely to have been a Nocardia sp than an Actinomyces sp.

Abortion, Veterinary↗
PubMed1976

The response of the mouse R-E system to infection with Toxoplasma gondii.

Groups of mice were inoculated with strains of Toxoplasma gondii of either high or low virulence strains. The response of the lymph nodes, speen and thymus was studied histologically and antibodies were assessed by the dye-test technique. The low-virulence strain induced changes in all three organs indicative of an immunological response, both in respect of cellular and humoral immunity. The high-virulence strain produced rapid lymphoid depletion in lymph nodes, spleen and thymus with areas of necrosis. It is suggested that the high-virulence strain has a toxic effect on the Reticulo-Endothelial system allowing urestricted proliferation of the organism with eventual death.

Animals↗
PubMed1976

Age-sex distribution of various diseases with particular reference to toxoplasmic lymphadenopathy.

An account is given of some human diseases which affect one sex more than the other. An age-sex realtionship has been noted among British patients with acquired toxoplasmic lymphadenopathy. This is compared with the findings of other European workers. A possible explanation is offered taking all these diseases into consideration together with some of the experimental work done in animals and some of the variations in immunological responses by man.

Adolescent↗
PubMed1973

Toxoplasmosis.

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Animals↗