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Biomedical subjects

J K Chambers

Publications and source records attributed to J K Chambers.

At least 37 records · Page 2Linked to original sources

Case study of the anemic patient: epoetin alfa--focus on blood pressure.

Patients with anemia caused by end-stage renal disease experience significant fatigue and decreased tolerance for activity. Epoetin alfa corrects anemia in virtually all of these patients, thereby providing several cardiovascular benefits, but some patients may develop increased blood pressure. Nephrology nurses should maximize the benefits of correcting anemia, while ensuring that blood pressure is optimally controlled, thus preserving cardiovascular function.

Aged↗

Development of an instrument to measure knowledge about kidney function, kidney failure, and treatment options.

The purpose of this article is to report the development of a valid and reliable instrument to measure knowledge in adults with decreased kidney function. The Chambers Kidney Knowledge Test (CKKT) will assist nurses and other nephrology health care providers to identify learning needs and individualize their instructional efforts with predialysis and dialysis patients.

Health Knowledge, Attitudes, Practice↗

Renal insufficiency: implications for care of the medical-surgical patient.

Renal insufficiency is a common co-existing diagnosis in many hospitalized patients. Nurses are in a key position to identify these patients, many of whom have diabetes mellitus, hypertension, or are elderly. Careful monitoring of renal function and risk factors may prevent the development of acute renal failure and/or the premature progression to end stage renal disease.

Adult↗

Water pressure and flow regulation for water-cooled lasers.

We experienced laser water valve failure resulting from poor water quality, frequent laser shutdowns from low water flow rates, and unnecessary service calls shortly after installing a new laser. The water valve failure resulted from deposits and corrosion. A dirt/rust water filter was installed, and no further water valve failure has occurred. A flow meter was added to the water system to adjust flow rates. It clearly shows when laser shutdowns are caused by low flow rates and indicates the need for water filter changes. Water pressure was monitored and is most affected by use of the laser. A convenient electric water control, activated by the laser key switch, has proved to be reliable. The water control is kept open by a timer ten minutes after the laser is shut off. We determined that our laser shutdowns were related to transient drops in water flow rates and possibly to draw off of water in other parts of the hospital.

Cold Temperature↗

Fluid and electrolyte problems in renal and urologic disorders.

Because the kidneys are primarily responsible for the regulation of fluid and electrolyte balance, acute or chronic changes in renal function can result in multiple imbalances. Acutely, the rapidity of onset of renal deterioration makes nursing assessment and intervention critical to the prevention of complications and potentially fatal outcomes. For patients with chronic renal failure, nursing assessment and intervention are equally significant, since there is an absence of renal regulatory mechanisms. In renal failure, acute or chronic, one most commonly sees patients who have a tendency to develop hypervolemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and bicarbonate deficiency (metabolic acidosis). Sodium is generally retained, but may appear normal, or hyponatremic, because of dilution from fluid retention. Following the relief of a urinary tract obstruction, hypovolemia, hyponatremia (true loss of sodium), hypokalemia, hypocalcemia, hypomagnesemia, and bicarbonate loss are most apt to occur. Electrolyte imbalances after urinary diversion vary depending on the site of urine diversion.

Acute Kidney Injury↗

Metabolic bone disorders. Imbalances of calcium and phosphorus.

This article describes the physiology of normal calcium and phosphorus metabolism and the influences of various hormonal agents. Clinical variables affecting the interpretation of calcium are explained. In addition, the effects of calcium and phosphorus excess and deficiency are described according to the nursing model. Two metabolic bone disorders, osteoporosis and renal osteodystrophy, are discussed in order to demonstrate the altered metabolic effects of calcium and phosphorus.

Bone Diseases, Metabolic↗

Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients.

Patients with diabetes mellitus manifest increased in vitro platelet aggregation and increased synthesis of the proaggregant and vasoconstrictor, thromboxane A2 (TXA2). We studied the effects of continuous insulin infusion treatment on platelet aggregation and arachidonic acid (AA)-stimulated platelet TXA2 synthesis (15 and 30 s post-AA, 1 mM) in 16 type I diabetic patients. Strict glycemic control was induced with the Biostator for 2 days and maintained for 12-14 days with continuous subcutaneous insulin infusion (CSII). The average premeal plasma glucose level (4/day) fell from 184 +/- 15, before treatment, to 107 +/- 6 mg/dl on the final day (P less than 0.001). After control, platelet synthesis of TXA2, measured by radioimmunoassay of its stable metabolite, immunoreactive TXB2 (iTXB2), decreased in all patients (30 s: 276 +/- 31 versus 199 +/- 28 ng iTXB2/ml/5 X 10(5) platelets; P less than 0.05). The reduction in platelet iTXB2 synthesis (15 and 30 s) was greater in poorly controlled patients (HbA1c greater than 12%; N = 8), and for all patients the decrease in iTXB2 (15 and 30 s) was correlated with the prestudy HbA1c level (15 s: r = 0.6; P less than 0.01). In contrast, platelet aggregation responses did not improve during intensive insulin treatment. The ED50 for AA (dose producing 50% maximum aggregation at 1 min) was unchanged after 2 wk of treatment and the ED50 for aggregation induced by ADP fell significantly in patients with HbA1c greater than 12% (2.8 +/- 1.3 versus 1.2 +/- 0.6 microM; P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Adenosine Diphosphate↗

Absence of abnormal erythrocyte superoxide dismutase, copper, or zinc levels in patients with retinitis pigmentosa.

Blood samples obtained from 22 patients with retinitis pigmentosa, 6 unaffected family members, and 8 unrelated controls showed serum copper and zinc to be in the normal range, contrary to the results in earlier reports. Likewise no significant variation of erythrocyte superoxide dismutase (SOD) and catalase levels was found between the 3 groups or when the patients were grouped by sex, age, or genetic distribution. The SOD proteins from controls and retinitis pigmentosa patients had identical mobilities on gel electrophoresis, isoelectric points, and heat stabilities. Our studies do not support the use of copper, zinc, or SOD in the diagnosis or treatment of retinitis pigmentosa.

Adolescent↗