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Biomedical subjects

J K McAlpine

Publications and source records attributed to J K McAlpine.

4 recordsLinked to original sources

Cardiac arrhythmias associated with upper gastrointestinal endoscopy in elderly subjects.

Continuous Holter monitoring was performed before, during and after upper gastrointestinal endoscopy in 50 unselected, consecutive elderly patients (median age 80 years: range 68-89). In contrast to other studies the patients received no atropine or opiate premedication and were monitored for a prolonged period usually 24 hours after endoscopy. Comparison of a control period when the patient was lying at rest before endoscopy with the period of endoscopy itself revealed an increased frequency of arrhythmias during endoscopy. Forty-eight per cent of patients developed a new arrhythmia or an increased frequency of existing arrhythmia during endoscopy. All arrhythmias were short and self-terminating. Evidence of cardiac disease conferred a significantly increased risk of developing an arrhythmia during endoscopy.

Aged↗

Myasthenia gravis and Schmidt syndrome.

We describe a 47 year old woman with a 30-year history of generalized myasthenia gravis whose condition had been stable and well controlled on a combination of pyridostigmine and ephedrine until she presented. At this time she gave a 2 month history of weakness, nausea, vomiting and more recently intermittent confusion. Investigations confirmed both primary hypothyroidism and primary adrenal failure (Schmidt syndrome). The autoimmune aetiology of these three conditions was confirmed by positive acetylcholine receptor, adrenal and thyroid microsomal antibodies.

Addison Disease↗

Hypomagnesaemia in elderly digitalised patients.

Hypomagnesaemia and hypokalaemia are known to predispose to digoxin toxicity. Elderly patients receiving diuretics may be at special risk. A 12-month survey of all patients receiving digoxin at the time of admission to our Geriatric Assessment Unit revealed 16% were hypomagnesaemic, whereas no patient was hypokalaemic. There is a need for greater awareness of the risk of magnesium depletion in elderly patients receiving concurrent diuretic and digoxin therapy.

Aged↗