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Biomedical subjects

J K McEnerney

Publications and source records attributed to J K McEnerney.

7 recordsLinked to original sources

Unfavorable neonatal outcome after intraamniotic injection of methylene blue.

A case is presented in which methylene blue dye was injected intraamniotically to confirm rupture of the membranes. Significant neonatal morbidity occurred as a direct result of the methylene blue dye injection. A syndrome of toxic side effects is described including hemolytic anemia, hyperbilirubinemia, and methemoglobinemia. The metabolic process is discussed. The authors suggest discontinuing the intraamniotic injection of methylene blue dye as a diagnostic aid.

Amnion↗

A new irrigating solution for intraocular surgery: TC Earle Solution.

Electrolyte solutions--Plasma-lyte, TC Medium 199, TC Medium 199 plus additional bicarbonate, TC Earle Solution, and glutathione bicarbonate Ringer Solution--were evaluated for effectiveness in maintaining corneal thickness and endothelial viability. The TC Earle Solution was shown to be the most effective commercially available solution; little difference was demonstrated between TC Earle Solution and the experimental GBR Solution. Glucose and bicarbonate were found to be essential ingredients in the efficacy of the TC Earle Solution.

Animals↗

Evaluation of the teratogenicity of fluorescein sodium.

Pregnant rabbits in their first and second "trimesters" of gestation were used in a controlled study to evaluate the teratogenicity of fluorescein sodium. Injections of the drug were given in doses comparable to those planned for human administration. No abortions or defects apparent at birth or as delayed manifestations were evident as a result of the drug therapy.

Abnormalities, Drug-Induced↗

In vitro evaluation of intraocular infusion fluids: effects on the lens and cornea.

Glutatione-bicarbonate-Ringer solution (GBR), GBR deficient in adenosine and glutathione, and a newly proposed glucose-phosphate-Ringer solution (GPR) have been found to maintain lens function and corneal endothelial viability with approximately equal efficacy during prolonged periods of incubation. Currently used intraocular irrigating solutions do not perform as well in maintaining the function of borderline decompensated lenses and in sustaining endothelial viability.

Animals↗