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Biomedical subjects

J K Robinson

Publications and source records attributed to J K Robinson.

At least 127 records · Page 7Linked to original sources
PubMed1985

Injectable collagen implant: histopathologic identification and longevity of correction.

This prospective study reports the results of the longevity of the correction achieved in 312 patients receiving injectable collagen implant and the histopathologic identification of the implant in the six who experienced reactions at the treatment sites. In reporting results in cosmetic patients, certain ones can be considered objective or factual, and other must be judged subjective. This study reports both kinds of results and proposes a new theory to explain the duration of the improvement.

Adult↗
PubMed1984

Effect of retinoic acid and low calcium conditions on surface glycoconjugates defined by differential lectin labelling in mouse epidermal cell culture.

The appearance of cell surface glycoconjugates (detected by fluorescein-isothiocyanate-conjugated lectins and bullous pemphigoid antibody) was serially examined in mouse epidermal cell cultures treated with trans-retinoic acid and aromatic retinoic acid (etretinate) and in cultures maintained under low calcium conditions. The changes in lectin staining occurred in concert with the process of differentiation as assessed by cell morphology and colony growth characteristics, and they correlated with the patterns observed in whole mouse skin. The keratocyte cultures treated with retinoic acid showed delayed and reduced differentiation and stratification, and this was associated with markedly reduced binding of lectins specific for N-acetyl-glucosamine and fucose. The low calcium concentration produced similar changes. Thus, the loss of surface glycoconjugates in the epidermal cell culture system was not specific for either retinoic acid or low calcium, but correlated with the degree of cell differentiation.

Animals↗
PubMed1984

Immunofluorescent and immunoperoxidase staining of antibodies to fibrous keratin. Improved sensitivity for detecting epidermal cancer cells.

Microscopically controlled surgery (Mohs' surgery) is a widely accepted technique because it provides total extirpation of skin tumors with maximum conservation of tissue. However, in poorly differentiated tumors it is often difficult microscopically to recognize individual tumor cells in the midst of an inflammatory cell infiltrate, in fibrotic tissue, in connective tissue around blood vessels, in nerve sheaths, and in fascial planes. We have developed techniques to differentiate tumor cells, derived from the epidermis, from the normal nonkeratinizing tissue of mesodermal origin or the inflammatory cell infiltrate. In frozen sections, indirect immunofluorescence techniques with polyclonal antibodies to fibrous keratin allowed rapid identification of tumor cells of basal and squamous cell carcinoma. Immunoperoxidase staining proved to be a remarkably sensitive method for the identification of such carcinoma cells in both frozen and paraffin-embedded sections. When used in combination with the precise mapping techniques of Mohs' surgery, these reliable and specific stains permitted greater accuracy in assessing the total resection of an invasive tumor.

Animals↗
PubMed1984

Essential primary cutis verticis gyrata. Treatment with the scalp reduction procedure.

A case of cutis verticis gyrata (CVG) occurred in a patient with no known associated disorders. Under the present classification system, patients with primary CVG are all grouped together. We propose subclassifying patients with primary CVG into two groups: those with associated neurologic and ophthalmologic diseases and those without. Our patient was treated with a scalp reduction procedure.

Adult↗
PubMed1983

Skin problems of aging.

It is not practical to treat diffuse areas of sun damage with liquid nitrogen. Patients with actinic keratoses require painstaking instruction and numerous visits to guide them through a course of 5-fluorouracil (5-Fu) therapy. While basal cell carcinoma rarely metastasizes, its potential for localized destruction and its tendency to recur after therapy should not be underestimated. In certain locations, the tumor does not have a benign clinical course.

Aged↗
PubMed1981

Attempts to enhance light microscopic diagnosis of cutaneous T-cell lymphoma (mycosis fungoides).

Precise pathologic criteria for the diagnosis of mycosis fungoides (MF) remain controversial. With the use of a specific counting technique and defined criteria for cell types, we attempted to differentiate between a series of slides from patients with eczematous dermatitis, large plaque parapsoriasis, and atypical dermatitis with features that suggest MF, the plaque stage of MF, and the tumor stage of MF. This could not be done on the basis of cellular density in e defined field in the papillary dermis or on the basis of the percentage of atypical lymphocytes in the fields counted. Furthermore, individual investigator variance was shown to be highly significant despite efforts to minimize this factor.

Cell Count↗
PubMed1980

Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals.

Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy.

Adult↗
PubMed1980

Invasion of cartilage by basal cell carcinoma.

Extensive analysis of ten factors in 183 consecutive cases of basal cell carcinoma overlying cartilage of the nose and ear is performed in this prospective study. Duration of tumor and prior treatment rather than one specific modality of previous therapy are significant factors in predicting tumor invasion of cartilage, which necessitates removal of cartilage.

Aged↗
PubMed1980

Variation in operative technique: the "nip 'n tuck" principle in dermatologic surgery.

Variations in operative technique to meet special circumstances in given cases and to take advantage of the natural elasticity of the skin have to be practiced for best results. The methods of "nip 'n tuck" tailoring are practicable in artful excisions of Burow's triangles, correction of "dog ears," and in devising H- and M-plasties to fit particular needs.

Adult↗