Biomedical subjects

J K Sahu

Publications and source records attributed to J K Sahu.

14 recordsLinked to original sources

PubMed2006

110 W double-ended ytterbium-doped fiber superfluorescent source with M2 = 1.6.

High-power operation of a broadband superfluorescent fiber source has been achieved via the process of amplified spontaneous emission (ASE) in a double-clad Yb-doped multimode-offset-core fiber by using a novel fiber-end termination geometry to suppress lasing. The fiber was cladding pumped by a high-power diode source at 976 nm and yielded a maximum ASE output of 63 and 47 W from the two ends of the fiber, respectively. The maximum combined ASE output was 110 W with slope efficiency with respect to launched pump power of up to 68%. The wavelength spectrum of the ASE source spanned the range from approximately 1032 to 1120 nm, and the bandwidth (FWHM) of the emission spectrum was 40 nm. The output beam was slightly multimode with a beam-quality factor (M2) of 1.6. The prospects for further improvement in performance are considered.

Journal Article↗

PubMed2006

Core area scaling of Nd:Al-doped silica depressed clad hollow optical fiber and Q-switched laser operation at 0.9 microm.

We demonstrate a Q-switched, cladding-pumped, Nd:Al-doped silica depressed clad hollow optical fiber (DCHOF) laser, which generated up to 133 microJ of pulse energy at a repetition rate of 5 kHz and 0.9 W of average output power at a high repetition rate (>20 kHz) in a diffraction-limited beam (M(2)=1.08) at 927 nm. The laser was tunable from 919 to 935 nm. This result shows the potential of the DCHOF structure for the suppression of unwanted long-wavelength radiation in large-area cores suitable for high-power Q-switched laser operation.

Journal Article↗

PubMed2006

High-power continuous-wave cladding-pumped Raman fiber laser.

We demonstrate a high-power single-mode cladding-pumped Raman fiber laser. The Raman fiber laser consists of a 1.2 km long germanium-doped double-clad fiber in a linear cavity, which is spliced to a single-mode fiber. The laser is end pumped by a multimode erbium-ytterbium-doped fiber, which is coupled to the inner cladding of the Raman fiber. The embedded core was designed to be single mode at the Raman Stokes wavelength, and up to 10 W of power was obtained at 1660 nm from the single-mode fiber end. The laser has a slope efficiency of 67% and a threshold of 6.5 W.

Journal Article↗

PubMed2006

Highly efficient in-band pumped Er:YAG laser with 60 W of output at 1645 nm.

A high-power Er:YAG laser that is in-band pumped by a high-power cladding-pumped erbium-ytterbium codoped fiber laser operating at 1532 nm is reported. The Er:YAG laser produced 60.3 W of continuous-wave output at 1645.3 nm in a beam with M2 approximately equal to 3 for 82 W of incident pump power and 20 W of TEM00 output with M2 < 1.2 for 32.4 W of incident pump power. The slope efficiency with respect to incident pump power at pump powers of >20 W was approximately 81%. In the Q-switched mode of operation, a slightly modified resonator configuration incorporating an electro-optic Q switch produced pulses of approximately 4 mJ energy and approximately 100 ns (FWHM) duration, corresponding to a peak power of approximately 42 kW at a repetition rate of 1 kHz for an incident pump power of 16.8 W. The prospects for further improvement in continuous-wave and Q-switched performance are discussed.

Journal Article↗

PubMed2006

Efficient single-mode operation of a cladding-pumped ytterbium-doped helical-core fiber laser.

A novel approach to achieving robust single-spatial-mode operation of cladding-pumped fiber lasers with multimode cores is reported. The approach is based on the use of a fiber geometry in which the core has a helical trajectory within the inner cladding to suppress laser oscillation on higher-order modes. In a preliminary proof-of-principle study, efficient single-mode operation of a cladding-pumped ytterbium-doped helical-core fiber laser with a 30 microm diameter core and a numerical aperture of 0.087 has been demonstrated. The laser yielded 60.4 W of output at 1043 nm in a beam with M2 < 1.4 for 92.6 W launched pump power from a diode stack at 976 nm. The slope efficiency at pump powers well above threshold was approximately 84%, which compares favorably with the slope efficiencies achievable with conventional straight-core Yb-doped double-clad fiber lasers.

Journal Article↗

PubMed2005

High-power tunable single-frequency single-mode erbium:ytterbium codoped large-core fiber master-oscillator power amplifier source.

We present a cladding-pumped single-frequency, single-mode erbium:ytterbium codoped fiber master-oscillator power amplifier source generating up to 151 W of continuous-wave output power at 1563 nm with 33% slope efficiency and 20 dB gain. This source was also tunable and had a stable operation range of 1546 to 1566 nm at an output power level in excess of 125 W. The doped fiber exploited a large-core design for improved power handling and mitigation of stimulated Brillouin scattering. There was no sign of having stimulated Brillouin scattering even at the highest power. Despite a large core (V = 12), the output beam was nearly diffraction limited (M2 = 1.1). The source showed slight rollover at over 100 W of output power because of the onset of emission from ytterbium, centered at 1060 nm.

Journal Article↗

PubMed2005

High-power Yb-doped multicore ribbon fiber laser.

A highly elongated double-clad ribbon fiber that comprises a pure-silica inner cladding with transverse dimensions of approximately 1.4 mm by 0.23 mm with a linear array of ten ytterbium-doped cores has been fabricated and operated in a simple laser configuration pumped by two diode stacks. The fiber laser yielded 320 W of output power at a center wavelength of 1045 nm in a combined beam with beam propagation factors of approximately 2 (perpendicular to the array) and approximately 150 (parallel to the array) for 576 W of launched pump power. The slope efficiency with respect to absorbed pump power was 62%. The prospects for further power scaling and improved beam quality and efficiency are discussed.

Journal Article↗

PubMed2005

Single-mode plane-polarized ytterbium-doped large-core fiber laser with 633-W continuous-wave output power.

We demonstrate a cladding-pumped single-mode plane-polarized ytterbium-doped fiber laser generating 633 W of continuous-wave output power at 1.1 microm with 67% slope efficiency and a polarization extinction ratio better than 16 dB. The laser is end pumped through both fiber ends and shows no evidence of roll-over, even at the highest output power, which is limited only by the available pump power.

Journal Article↗

PubMed2005

Single-frequency, single-mode, plane-polarized ytterbium-doped fiber master oscillator power amplifier source with 264 W of output power.

We present a single-frequency, single-mode, plane-polarized ytterbium-doped all-fiber master oscillator power amplifier source at 1060 nm generating 264 W of continuous-wave output power. The final-stage amplifier operated with a high gain of 19 dB and a high conversion efficiency of 68%. There was no evidence of rollover from stimulated Brillouin scattering even at the highest output power, and the maximum output was limited only by the available pump power.

Journal Article↗

PubMed2003

High-power, low-noise, Yb-doped, cladding-pumped, three-level fiber sources at 980 nm.

We present results on a high-power, cladding-pumped, Yb-doped fiber emitting at 977 nm in laser and ampllified-spontaneous-emission source configurations. We obtained up to 1.4 W of fiber-coupled, single-mode output power and slope efficiency as high as 68%. To our knowledge these are the highest powers efficiencies achieved from a single-mode fiber laser at approximately 980 nm and the first demonstrated results on a high-power amplified-spontaneous-emission source in this wavelength range. High power and high slope efficiency are achieved by using a high numerical aperture (> 0.7), a jacketed air-clad fiber, and a high-brightness pump source. Both types of sources exhibit relative intensity noise below -130 dB/Hz and are thus suitable for a wide range of applications.

Journal Article↗

PubMed1990

Changes in lipid profiles of brain of albino rats following envenomation.

Effect of high doses of cobra venom (150 micrograms/120 +/- 20 g body weight) and viper venom (300 micrograms/120 +/- 20 g body weight) on total lipid, triglyceride, phospholipid, cholesterol, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of brain of albino rats was studied. Total lipid (TL) triglyceride (TG) and phospholipid (PL) are decreased in both viper and cobra venom treated groups while cholesterol (C), and LDL-C are increased in both the groups in relation to controlled ones. HDL-C content was almost unaltered. Decrease in triglyceride and phospholipid may be due to effect of lipases and phospholipases whereas increased cholesterol and LDL-C may be attributed to lysis of cell membrane.

Animals↗

PubMed1990

Biochemical studies of liver & liver microsomes in envenomated rats.

Some biochemical parameters of liver and liver microsomes were studied in albino rats following administration of cobra and viper venoms at dose of 2 mg/kg body weight. The total protein content in cobra venom treated (CVT) animals and DNA and RNA contents of liver and liver microsomes were almost unaltered in both the venom treated animals while total protein content was significantly reduced in viper venom treated (VVT) animals. Alkaline and acid phosphatases activities of whole liver showed significant increase in both the venom treated animals whereas the rise in cholinesterase activity in CVT animals was not significant. Lactic acid content was significantly higher in CVT animals compared to either VVT animals or controls. The glycolytic enzymes viz., aldolase, phosphohexose isomerase and lactate dehydrogenase measured in hepatic microsomal fraction were significantly reduced while alanine and aspartate aminotransferases and gamma-glutamyl transpeptidase activities of liver microsomes were significantly elevated in both the venom treated animals compared to controls.

Animals↗

PubMed1989

Effect of envenomation on enzymes of brain of albino rats.

Effects of high doses of cobra venom, (150 micrograms/120 +/- 20 g body wt) and viper venom (300 micrograms/120 +/- 20 g body wt) on aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), acetylcholinesterase (ACh) and alkaline phosphatase (ALP) of brain of albino rats were studied. While AST, LDH, ACh and ALP activities increased in both viper and cobra venom treated rats, ALT decreased in both groups compared to control.

Animals↗

PubMed1988

Utilization of organic substrates by two filamentous cyanobacteria under various growth conditions.

Two filamentous cyanobacteria Calothrix marchica Lemm. var. intermedia Rao and Scytonema schmidlei De Toni grew heterotrophically in light with or without DCMU and in the dark when supplemented with glucose, fructose or sucrose. Galactose, mannitol and sorbitol were utilized less efficiently. Mannose, xylose and organic acids did not support the heterotrophic growth of both the cyanobacteria. By continuous incubation and sub-cultivation in sucrose supplemented medium in the dark, heterotrophic adapted strains of the organisms were produced. These strains, in contrast to the light pre-treated ones, readily utilized the exogenous substrate as evidenced by increase in growth and the total nitrogen content of the cultures.

Carbohydrate Metabolism↗