Biomedical subjects

J Könneke

Publications and source records attributed to J Könneke.

2 recordsLinked to original sources

PubMed1989

[EEG findings during the course of HIV infection].

Clinical neurological complications in HIV-infection (Human Immunodeficiency Virus) are seen in later stages of the disease. EEGs of 186 patients in different stages of HIV-infection and of 44 HIV-seronegative volunteers (total of 566 recordings) were evaluated visually; this revealed an increasing appearance of CNS-dysfunction (slowing of background activity, focal and diffuse CNS-dysfunction) associated with a progression of the disease. Slowing of background activity was already found in early stages of HIV-infection. Additional focal and diffuse changes in the electrical activity of the brain are also seen with progression of the infection (LAS/ARC-AIDS). The correlation between these electroencephalographic changes and HIV related clinical symptoms are non specific however, EEG recordings can be a valuable aid in following CNS-dysfunction during the course of HIV-infection.

AIDS-Related Complex↗

PubMed1989

[Polygraphic sleep data in AIDS patients].

Somnopolygraphic recordings were registered from 29 patients with AIDS, their age ranged from 20 to 55 years (mean: 40.9; median: 44). The patients represent the full range of cerebral disintegration representing the picture of a progressing destruction of physiological sleep organization. Some disturbances begin quite early and progress successively, such as the reduction of REM- and delta-sleep as well as the reduction of sleep spindle- and K-complex-densities. Other changes are not manifest until intellectual capabilities break down; they occur massively such as the shortening of real sleep time and the reduction of sleep stage 2 with a simultaneous increase in waking time. It is remarkable that despite the enormous REM reduction there is no suppression of REM periods corresponding to "REM sine REM". REM periods become very short at an early stage; this is not only because the patients awake more frequently and earlier from their dream periods.

Acquired Immunodeficiency Syndrome↗