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Biomedical subjects

J Kaczmarczyk

Publications and source records attributed to J Kaczmarczyk.

At least 19 recordsLinked to original sources
PubMed2004

Human response to personalized ventilation and mixing ventilation.

UNLABELLED: The response of 60 human subjects to a personalized ventilation system (PVS), providing control of positioning of the air terminal device and the airflow rate, was compared with the response to mixing ventilation (MV). Perceived air quality, thermal comfort, intensity of Sick Building Syndrome symptoms and performance of subjects were studied during 3 h 45 min exposures. In case of MV alone the room air temperature was 23 degrees C and 26 degrees C. The PVS supplied outdoor air at 23 degrees C or 20 degrees C or recirculated room air at 23 degrees C when the room temperature was 23 degrees C, and outdoor air at 20 degrees C when the room temperature was 26 degrees C. The PVS providing outdoor air improved perceived air quality and decreased SBS symptoms compared to MV alone and when the room air was re-circulated through the PVS. The percentage dissatisfied with air quality, 3 min after initial occupancy, decreased from 22% with MV to 7% with PVS; and from 49% to 20%, at room temperatures 23 degrees C and 26 degrees C, respectively. Over time, these differences in percentage dissatisfied decreased markedly. Headache and decreased ability to think clearly were reported as least intense when the PVS supplied outdoor air at 20 degrees C, while the most intense symptoms occurred with MV. PVS increased self-estimated performance. PRACTICAL IMPLICATIONS: Personalized ventilation can improve occupants' thermal comfort, perceived air quality and decrease the intensity of SBS symptoms compared to mixing ventilation. Occupants will use the provided individual control of airflow rate and positioning of the air terminal device to obtain preferred microenvironment in rooms where the air temperature is within the range recommended by indoor climate standards. Development of more efficient air terminal devices is recommended.

Adult↗
PubMed2001

Oxazolidinones mechanism of action: inhibition of the first peptide bond formation.

Oxazolidinones are potent inhibitors of bacterial protein biosynthesis. Previous studies have demonstrated that this new class of antimicrobial agent blocks translation by inhibiting initiation complex formation, while post-initiation translation by polysomes and poly(U)-dependent translation is not a target for these compounds. We found that oxazolidinones inhibit translation of natural mRNA templates but have no significant effect on poly(A)-dependent translation. Here we show that various oxazolidinones inhibit ribosomal peptidyltransferase activity in the simple reaction of 70 S ribosomes using initiator-tRNA or N-protected CCA-Phe as a P-site substrate and puromycin as an A-site substrate. Steady-state kinetic analysis shows that oxazolidinones display a competitive inhibition pattern with respect to both the P-site and A-site substrates. This is consistent with a rapid equilibrium, ordered mechanism of the peptidyltransferase reaction, wherein binding of the A-site substrate can occur only after complex formation between peptidyltransferase and the P-site substrate. We propose that oxazolidinones inhibit bacterial protein biosynthesis by interfering with the binding of initiator fMet-tRNA(i)(Met) to the ribosomal peptidyltransferase P-site, which is vacant only prior to the formation of the first peptide bond.

Drug Interactions↗
PubMed1999

Complementary and alternative medicine: herbal therapies for diabetes.

Interest in and use of complementary and alternative medicine have increased in recent years, with as much as 40% of the general population having used some form of complementary and alternative medicine in the past year. Although recent national surveys have not adequately assessed the use of complementary and alternative medicine in minority populations, its use in many minority populations is at least equal to and possibly greater than that in the general population. One condition for which minority populations are likely to use complementary and alternative medicine therapies is diabetes, which is particularly prevalent in Mexican-American and Native-American communities. Many minority cultures have a long history of using herbal preparations to treat diabetes, and recent research suggests that some herbal therapies may have a role in the treatment of this complex disease. However, many questions remain regarding the proper use of herbal therapies for diabetes, particularly in regard to dosage and contaminants. Therefore, physicians who work with minority populations should ask patients about their use of these therapies and must become knowledgeable about their safety and efficacy.

Diabetes Mellitus, Type 2↗
PubMed1995

[Terminology of scoliosis].

The most important entries concerning scoliosis have been presented in an alphabetical order. Some definitions, better describing three-planar scoliosis deformity, suggested by Scoliosis Research Society have been included.

Humans↗
PubMed1994

[Early results of surgical treatment for congenital hip dislocation in children using Degi's method in children under 18 months of age].

Early results of surgical treatment of congential hip dislocation by the Dega method in 18 children (20 hips) aged from 6 to 17 months are presented. Following the excision of the soft tissue obstructions and Dega transiliac osteotomy stable reduction of the hip has been achieved in all cases. Proximal femoral osteotomy has been performed in 6 cases only. Clinical results were markedly superior over radiological ones. Fair radiological outcomes resulted from surgical errors or avascular necrosis of the femoral head due to the previous conservative treatment. Avascular necrosis after operative treatment has not been noted.

Hip Dislocation, Congenital↗
PubMed1993

Microscopic picture of the vesicular glands in young boars with respect to feeding level.

On 27 German Landrace boars studies were conducted to describe the effect of feeding level during the growth period on the microscopic picture of vesicular glands in boars at 5, 6 and 7 months of age. Investigations have shown that differentiation of feeding level during the growth period affected the development of internal structures of the parenchyma in the boars' vesicular glands. The size of the tubules, their number within the field of vision and height of glandular epithelium lining the tubules were the highest in the group of animals fed at increased level.

Animal Feed↗