Biomedical subjects

J Karádi

Publications and source records attributed to J Karádi.

4 recordsLinked to original sources

PubMed1996

Effectiveness of multivisceral resection in surgery for gastrointestinal cancers.

A retrospective analysis was conducted on 196 patients who underwent surgery involving multivisceral resection for adenocarcinoma of the abdominal digestive tract, 101 of whom were over 70 years old. Resection or removal of a neighboring organ was justified by either tumorous involvement of the organ, oncological principles, or the surgical technique required. Thus, in addition to the primary tumorous organ, two other organs were resected or removed in 134 patients, and three or more other organs were resected or removed in 62 patients. The mortality rate was 5% in the former group, and 16% in the latter group, showing an overall mortality rate of 7.5% for the 196 multivisceral operations. Moreover, the 5-year survival rate of patients with microscopic evidence of tumorous involvement of the resected neighbouring organs was significantly lower than that of those without any evidence of involvement.

Adenocarcinoma↗

PubMed1992

[Preparation for elective colon surgery using the mannitol-ceftriaxone method].

The study includes 450 patients undergoing elective colorectal surgery. Patients were divided in three groups. 140 patients were prepared with conventional enema and purgatives and a Neomycin-metronidazole prophylaxis. 160 patients of the second group were prepared with mannitol (10%) oral 12 hours before the operation and a single dose of ceftriaxone (Rocephin) 2 g intravenously 2 hours before surgery. 150 patients of the third group were prepared with mannitol by the same way described above, and a combination of ceftriaxone 2 g i. v. and metronidazole 500 mg. i. v. two hours before the operation. The study proved that the mannitol combined with ceftriaxone provides a sufficient preparation for colorectal surgery within 12 hours prior the operation. The rate of septic complications and septic deaths was higher in the first group then in the two others. The combination of metronidazole used in the third group showed no advantage versus single dose ceftriaxone alone.

Cathartics↗

PubMed1982

Metronidazole in the chemoprophylaxis of colon and rectum operations.

In the preparation of colorectal operations, beside the mechanical cleaning of the bowels, orally administered metronidazole, acting on anaerobic bacteria, was found to be highly effective. Compared to the controls, the drug considerably reduced the number and severity of postoperative infections, and, consequently, also the mortality. With metronidazole prophylaxis no wound suppuration indicating anaerobic infection was noted. The combined application of metronidazole with some antibiotic acting on the aerobic bacteria of the intestinal flora resulted in a significant reduction of postoperative infections.

Adult↗

PubMedDate not supplied

The "Mannit-Ceftriaxon" preparation for elective colorectal surgery.

Authors report their experiences with evaluating the clinical course of 45 patients undergoing elective colorectal surgery. Patients were divided into three groups, depending on the type and method of preparation to operation. The 140 patients in the first group received according to the "traditional" preparation purgatives, enemas, and mycerine + metronidazole prophylaxis. The preparation of the 160 patients involved in the second group was performed by giving mannit solution (10%) orally 12 hours prior to surgery, and a single dose of 2 g ceftriaxon (Rocephin, Hoffman-La Roche) intravenously 2 hours preoperatively. The preparation for the 150 patients enrolled into the third group was done also by giving mannit solution orally, and for antibiotic prophylaxis 2 g ceftriaxon was given intravenously as in the second group, but an additional 500 mg metronidazole was also given at the same time as the ceftriaxon intravenously. The evaluation of the cases proves, that the mannit + ceftriaxon method warrants satisfactory protection for colorectal surgery, and the necessary time interval is only 12 hours. The rate of septic complications and septic death was higher in the first, traditionally pretreated group, than in the other two. The CTX + metronidazole combination used in the third group was not superior to the administration of ceftriaxon alone.

Aged↗