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J Karner-Hanusch

Publications and source records attributed to J Karner-Hanusch.

25 records · Page 2Linked to original sources
PubMed1993

[Determinants of pouch function after continence-preserving proctocolectomy].

A prospective study was undertaken in 17 patients undergoing restorative proctocolectomy for ulcerative colitis (13 patients) or familial adenomatous polyposis (4 patients) to determine relationship between pre- and postoperative anal sphincter function, pouch characteristics and functional results. Postoperatively all manometric parameters were significantly reduced and remained so permanently. Only squeeze pressure rose to normal values again. The most important factor for a favourable functional outcome was pouch volume. A capacious reservoir was associated with a low stool frequency, low risk of incontinence and general success of the operation, as assessed subjectively. Perianal soreness with considerable skin problems occurred frequently when resting and squeeze pressures were markedly reduced postoperatively.

Adenomatous Polyposis Coli↗
PubMed1989

[Familial colon cancer].

5 families with autosomal dominant inherited colonic cancer were analyzed with reference to the characteristics of familial colonic cancer: 45% out of 54 family members had colorectal carcinomas, with a mean of 4.5 affected members per family. The mean age on diagnosis of colonic cancer was 43.9 years. 50% of the colorectal carcinomas were located in the right colon; 11 out of 14 carcinomas were Dukes C, with a predominance of poorly differentiated adenocarcinomas and mucin-producing cancers. 22% had synchronous cancers and 13% developed metachronous cancers. Cancer at another location was found in 8.7% of cases. Prospective screening of relatives (siblings, children) revealed a colonic neoplasm in 3 out of 6 asymptomatic subjects. The typical characteristics of familial colonic cancers were demonstrable in our patients. The elucidation of an exact family history in all patients with colorectal carcinoma and a strategy of meticulous surveillance are absolutely necessary for the diagnosis and management of this inherited trait.

Adenocarcinoma↗
PubMed1989

Plasma glutamate--a prognostic marker of cancer and of other immunodeficiency syndromes?

Elevated plasma levels of glutamate (GLU) have been reported to occur in patients with malignancies and other immunodeficiency syndromes (IDS). To evaluate, whether GLU is useful as prognostic indicator, the plasma concentrations were determined in patients with colorectal carcinoma (CRC), with breast cancer (BRC), and with HIV-infection (HIV). The results were correlated with the disease-stages, and compared with data obtained from patients with benign diseases of the same organ, as well as from sex-matched healthy volunteers. GLU concentrations (volunteers: 27.4 +/- 17.6 mumol/l) were elevated in all BRC patients (range of mean values: 53.5-83.2 mumol/l), in CRC patients with T2-T4-tumours (means: 46.8-85.9), and in HIV+ patients of stage WR 5, 6 (means: 53.9-69.7 mumol/l). All CRC- and BRC-patients with metastases showed highly significant elevations of GLU concentrations (p less than 0.001), but there were no direct correlations between disease stages and GLU levels. Pre-operative patients with benign diseases (diverticulitis, adenoma = GID; and mastopathy = MTP) showed increased GLU levels, which were comparable to those of the tumour patients. The glutamine/GLU ratios (volunteers: 19.3 +/- 15.0) were decreased only in HIV-WR 6 (7.6 +/- 2.1), and BRC-stage 4 (8.0 +/- 1.7). From these results we deduce that the plasma GLU concentrations do not allow a discrimination either between patients with malignancies and without, and between persons of different disease stages.

Aged↗
PubMed1987

[Value of CT following surgery for rectal cancer (a prospective study)].

The results of computed tomography of 48 patients after operation on rectal carcinoma who underwent close-meshed computer tomographic examinations are given in a prospective study. (First examination 6 weeks after operation, further examinations at intervals of 3 months, mean observation time: 12 months). The results of follow-up by means of computer tomographic examination are compared with clinical examinations and control of CEA levels. The use of computer tomographic examination resulted in 43 confirmed negative, 3 confirmed positive and 2 false negative findings (including cases with CT-aided fine needle biopsy). These results give an accuracy of 96% and thus exceed clinical examination and controls of CEA-level. How far early diagnosis of local recurrence of rectal cancer influences survival time, can be answered after completion of this study in the next few years.

Adenocarcinoma↗
PubMed1986

Results of coloanal anastomosis. A prospective study.

Anterior resection with colo-anal anastomosis was carried out in 40 patients. The main indications were rectal neoplasia (30 cases) and irradiation proctitis (8 cases). Early complications occurred in 12 patients and three died of cardiopulmonary complications. Fistula formation and stenosis were the most frequent late complications. In 23 patients with adenocarcinoma operated for cure there was one recurrence. The functional results were good, although it often took up to 1 year until satisfactory continence, stool consistency and frequency were obtained. Manometry showed a significant decrease in anal canal length and resting tone postoperatively. The method is a practicable alternative to total rectal excision.

Aged↗