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Biomedical subjects

J Kelner

Publications and source records attributed to J Kelner.

5 recordsLinked to original sources

[Laryngeal neuroendocrine carcinoma (carcinoid)].

Neuroendocrine carcinoma (carcinoid), is a rare laryngeal malignancy with aggressive behavior. The 5-year survival rate is only about 10%, mainly because of distant metastases. We describe a patient with neuroendocrine carcinoma of the larynx, large cell type, without evidence of regional or distant metastases. Treatment included total laryngectomy and adjuvant radiotherapy to the neck. There was no evidence of disease at 6-month follow-up.

Aged

Tonsillar leiomyoma.

Tumors of smooth muscle origin are rare in the oral cavity. To date, only eighty-three cases of oral leiomyomas have been reported. A first case of tonsillar leiomyoma in a 73-year-old male is presented. The theories of origin and the various histologic types of oral leiomyomas are discussed. Leiomyoma can easily be confused with other spindle-cell tumours. Special stains are necessary to reach a correct diagnosis. It is sometimes difficult to differentiate benign leiomyoma from malignant leiomyosarcoma. The use of mitotic figure count to indicate malignant behaviour is not always reliable. The need for wide surgical excision of the tumour, complete sectioning and examination of the specimen and meticulous follow-up of the patient for evidence of recurrence are emphasized.

Aged

Congenital middle ear encephalocele initially seen with facial paresis.

Congenital middle ear encephalocele (CMEE) is a rare entity, previously reported in only 29 patients. It might originate from dehiscence of the tegmen tympani or antri or the bony plate of the posterior fossa. The common presenting symptoms are spontaneous cerebrospinal fluid (CSF) otorrhea and/or rhinorrhea, persistent "serious otitis media," conductive hearing loss, and, occasionally, recurrent meningitis. We report a case of CMEE initially seen with progressive facial paresis, review the previously reported cases of CMEE, and discuss the pathogenesis and surgical management.

Cerebrospinal Fluid Otorrhea