PubMed Health⌕ Search

Biomedical subjects

J Kesselring

Publications and source records attributed to J Kesselring.

At least 19 recordsLinked to original sources
PubMed2004

Escalating immunotherapy of multiple sclerosis--new aspects and practical application.

Recent clinical studies in multiple sclerosis (MS) provide new data on the treatment of clinically isolated syndromes, on secondary progression, on direct comparison of immunomodulatory treatments and on dosing issues. All these studies have important implications for the optimized care of MS patients. The multiple sclerosis therapy consensus group (MSTCG) critically evaluated the available data and provides recommendations for the application of immunoprophylactic therapies. Initiation of treatment after the first relapse may be indicated if there is clear evidence on MRI for subclinical dissemination of disease. Recent trials show that the efficacy of interferon beta treatment is more likely if patients in the secondary progressive phase of the disease still have superimposed bouts or other indicators of inflammatory disease activity than without having them. There are now data available, which suggest a possible dose-effect relation for recombinant beta-interferons. These studies have to be interpreted with caution, as some potentially important issues in the design of these studies (e. g. maintenance of blinding in the clinical part of the study) were not adequately addressed. A meta-analysis of selected interferon trials has been published challenging the value of recombinant IFN beta in MS. The pitfalls of that report are discussed in the present review as are other issues relevant to treatment including the new definition of MS, the problem of treatment failure and the impact of cost-effectiveness analyses. The MSTCG panel recommends that the new diagnostic criteria proposed by McDonald et al. should be applied if immunoprophylactic treatment is being considered. The use of standardized clinical documentation is now generally proposed to facilitate the systematic evaluation of individual patients over time and to allow retrospective evaluations in different patient cohorts. This in turn may help in formulating recommendations for the application of innovative products to patients and to health care providers. Moreover, in long-term treated patients, secondary treatment failure should be identified by pre-planned follow-up examinations, and other treatment options should then be considered.

Clinical Trials as Topic↗
PubMed2004

Quantification of Uhthoff's phenomenon in multiple sclerosis: a magnetic stimulation study.

OBJECTIVE: To quantify temperature induced changes (=Uhthoff phenomenon) in central motor conduction and their relation to clinical motor deficits in 20 multiple sclerosis (MS) patients. METHODS: Self-assessment of vulnerability to temperature and clinical examination were performed. We used motor evoked potentials to measure central motor conduction time (CMCT) and applied the triple stimulation technique (TST) to assess conduction failure. The TST allows an accurate quantification of the proportion of conducting central motor neurons, expressed by the TST amplitude ratio (TST-AR). RESULTS: Temperature induced changes of TST-AR were significantly more marked in patients with prolonged CMCT (P=0.037). There was a significant linear correlation between changes of TST-AR and walking velocity (P=0.0002). Relationships were found between pronounced subjective vulnerability to temperature and (i) abnormal CMCT (P=0.02), (ii) temperature induced changes in TST-AR (P=0.04) and (iii) temperature induced changes in walking velocity (P=0.04). CMCT remained virtually unchanged by temperature modification. CONCLUSIONS: Uhthoff phenomena in the motor system are due to varying degrees of conduction block and associated with prolonged CMCT. In contrast to conduction block, CMCT is not importantly affected by temperature. SIGNIFICANCE: This is the first study quantifying the Uhthoff phenomenon in the pyramidal tract of MS patients. The results suggest that patients with central conduction slowing are particularly vulnerable to develop temperature-dependent central motor conduction blocks.

Adult↗
PubMed2003

Fatigue in MS is related to sympathetic vasomotor dysfunction.

The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.

Adult↗
PubMed2003

Fitness to drive with neurological disabilities.

To restore the ability to drive is one aim of the rehabilitation of patients with neurological disabilities. In some instances, an evaluation is required to judge a patient's fitness to drive in today's traffic. Forty-three patients of the neurorehabilitation unit of the Valens Clinic were assessed by a standard traffic psychological test protocol and a control drive. In 88%, there was agreement between the judgments based on each procedure. Four patients had failed either the psychological tests or the control drive but not both. Six patients had failed the psychological test and the control drive. Two drove nevertheless, and three patients stopped driving. Nineteen of 32 patients cleared to drive were followed up. Eleven drove without accidents or traffic fines. The traffic psychological tests and control drive yield complementary information on the fitness to drive. However, the assessments need to be improved. New generations of interactive driving simulators may refine the fitness to drive evaluation and become useful tools in driving rehabilitation.

Accidents, Traffic↗
PubMed2002

Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis.

Multiple sclerosis (MS) patients of an inpatient rehabilitation program have been randomly assigned to an exercise training (MS-ET) or nontraining group (MS-NI). Before and after 4 weeks of aerobic exercise training, a graded maximal exercise test with measurement of gas exchange and a lung function test was administered to all 26 patients fulfilling the inclusion criteria. Activity level, fatigue and health perception were measured by means of questionnaires. Twenty-six healthy persons served as control group and were matched in respect of age, gender and activity level. Training intervention consisted of 5x30 min sessions per week of bicycle exercise with individualised intensity. Compared with baseline, the MS training group demonstrated a significant rightward placement of the aerobic threshold (AT) (VO2+13%; work rate [WR])+11%), an improvement of health perception (vitality+46%; social interaction+36%), an increase of activity level (+17%) and a tendency to less fatigue. No changes were observed for the MS-NI group and the control groups. Maximal aerobic capacity and lung function were not changed by either training or nontraining in all four groups. Overall compliance to the training program was quite low (65%), whereas incidence of symptom exacerbation by physical activity has been lower than expected (6%).

Adult↗
PubMed2001

Cognitive and affective disturbances in multiple sclerosis.

The emotional and relationship problems associated with MS have not always been fully appreciated by the medical profession, which has tended to concentrate on the physical aspects of this disease. Yet the psychological problems of MS often cause more suffering than physical effects.

Cognition Disorders↗
PubMed2001

Neuroscience and clinical practice: a personal postscript.

For such complex endeavours as understanding functions of the nervous system and treating patients with impairments of such functions, a continuous exchange of ideas in mutually understandable language is needed between researchers and clinicians. Neither of them is capable in the long run of doing justice to the scientific aspects of neuroscience and neurology and to the expectation of the patients on his or her own. It should become possible to bridge the gap between caring for patients and a scientific understanding of the mechanisms by which certain therapies work and the measurement of performance and outcome which is important for the credibility of interventions. The scientific approach to neurology has led to remarkable improvements in understanding some of the disease processes and to some valuable new therapies. There is no fundamental contradiction, however, between this approach and the pastoral aspects of medical care.

Burnout, Professional↗
PubMed2001

Neurorehabilitation: a bridge between basic science and clinical practice.

A true paradigm shift or revolution of thinking is taking place in the field of neurology. Earlier, it was regarded as the science of exact diagnosis of incurable illnesses, according to the resigned dogma that damage to the central nervous system could not be repaired: "Once development is complete, the sources of growth and regeneration of axons and dendrites are irretrievably lost. In the adult brain the nerve paths are fixed and immutable: everything can die, nothing can be regenerated" (Cajal, 1928). Even then one could have countered this with what holds today: "Rehabilitation does not take place in the test tube!", and one would have been supported only a short time later by a most authoritative source, if one had read and quoted what the professor of neurology and neurosurgery in Breslau, Otfried Foerster, wrote in a 100-page article about therapeutic exercises that appeared in the Handbuch der Neurologie. From his introduction, only three sentences are quoted, which illustrate his opinion of the importance of therapeutic exercises and are closer to our views of brain functions today (Foerster, 1936): There is no doubt that most motor disturbances caused by lesions of the nervous system are more or less completely compensated as a result of a tendency inherent to the organism to carry out as expediently as possible the tasks of which it is capable under normal circumstances, using all the forces still available to it with the remaining undamaged parts of the nervous system, even following injury to its substance. This happens spontaneously, when neither a reversal of the noxa nor a regeneration of the destroyed tissue is possible, simply by means of a reorganization of the remaining parts of the nervous system, which is not a machine composed of individual parts that stands still when one part fails; rather, it possesses an admirable plasticity and exhibits an astonishingly extensive adaptability, not only to changed external conditions but also to disruptions of its own substance. Therapeutic exercises influence the course of spontaneous restoration; they support it, strengthen it. Not infrequently, in fact, they actually set it in motion when the forces essential to restoration lie fallow and are not deployed by the organism.

Clinical Protocols↗
PubMed2001

Increased endothelin-1 plasma levels in patients with multiple sclerosis.

OBJECTIVE: We tested the hypothesis that the plasma level of endothelin-1 (ET-1) is increased in patients with multiple sclerosis (MS). The peptide ET-1 is one of the most potent known vasoconstrictors. An increased level of endothelin could explain some of the vascular symptoms of these patients. MATERIALS AND METHODS: A specific radioimmunoassay was used to determine ET-1 plasma levels. Twenty patients with MS were compared to 20 age- and sex-pair-matched healthy subjects. RESULTS: The plasma ET-1 levels were, on average, 224% higher in the patients with MS than in the controls (p < 0.005). The mean ET-1 levels (mean +/- standard deviation [SD]) were 3.5 +/- 0.83 pg/mL (min 2.13, max 5.37 pg/mL) in patients with MS and 1.56 +/- 0.3 pg/mL (min 0.9, max 2.13 pg/mL) in healthy volunteers. Neither the different forms nor stages of MS had an influence on the results. The ET-1 level was also not correlated with the duration of the disease. CONCLUSIONS: The plasma ET-1 level is markedly and significantly increased in patients with MS. Neither the cause of such an increase nor the pathogenetic role is known.

Adult↗
PubMed2001

Impact of neurorehabilitation on disability in patients with acutely and chronically disabling diseases of the nervous system measured by the Extended Barthel Index.

To study the impact of rehabilitation on disability in an unselected patient group with acutely and chronically disabling neurologic diseases, the Extended Barthel Index (EBI) was determined at the beginning and at the end of the rehabilitation stay in all patients admitted to our Neurorehabilitation Centre in Valens, Switzerland. Patients who reached the highest possible EBI score at entry ("ceiling effect"), with a short stay (<1 week), or with a deterioration due to other medical complications were excluded. Finally EBI data of 743 patients could be analyzed. The mean EBI at entry was 45 and 51 at discharge. The mean increase of the EBI score per week was 1.1 (SD, 1.7). The change of the EBI score was analyzed independently in patients with acute neurologic diseases admitted in the postacute phase (acute group) and patients with chronically disabling neurologic diseases (chronic group). As expected, the increase of the EBI score was higher in the acute group than in the chronic group; 80.8% of the acute group patients and 42.5% of the chronic group patients showed an increase of the EBI score at discharge. Both groups showed a significant EBI gain with a marked shift to higher EBI scores at discharge. The mean gain per week was 1.6 in the acute group and 0.5 in the chronic group, respectively. Analysis of EBI changes considering the different underlying diseases showed the highest increase in patients with stroke and traumatic brain injury.

Activities of Daily Living↗
PubMed2000

Constantin von Monakow's formative years in Pfäfers.

Constantin von Monakow was the first professor of neurology in Switzerland and founder of the Swiss Neurological Society and of the Swiss Archives of Neurology and Psychiatry. He gained worldwide reputation as a neuroscientist mainly through his monumental work on neuropathology and cortical localization. His concept of diaschisis has been verified only in recent years by modern network concepts and imaging techniques. The basis of his work was developed with ingenious animal experiments and careful clinico-pathological comparisons during his early years, which he spent as assistant physician in the psychiatric clinic at St. Pirminsberg in Pfäfers, Canton St. Gallen, Switzerland from 1878 to 1885.

Animals↗
PubMed2000

Reversible neuropsychological deficits after mild traumatic brain injury.

OBJECTIVES: To determine the influence of motivation on performance in a divided attention test of patients after mild traumatic brain injury (MBI). METHODS: Comparison of the performance of 12 patients with MBI with 10 patients with severe brain injury (SBI) and 11 healthy controls in a computer supported divided attention task before (T1) and after (T2) verbal motivation. RESULTS: At T1, the MBI group performed the same as the SBI group but significantly worse than the controls in all variables. At T2, the MBI group performed worse than the controls at T2 but the results were equal to the results of the controls at T1 and significantly better than the SBI group at T1 or T2. At T2 the MBI group performed at the level of published norms for the rest. CONCLUSION: Before verbal motivation the MBI group's results in the divided attention task were comparable with those from patients with severe brain injury. They failed to exploit their performance potential when it depended on self motivation but were able to perform at the level of the control group when external motivation was applied.

Adult↗
PubMed1999

[How is the brain tuned?].

The brain is the organ which organizes the interaction between the organism and the environment. On the afferent side perceptive channels provide information from the outer and inner worlds. On the efferent side there is only the muscle system with its governing neural organisation. The brain as a tool or instrument can be put in tune like an instrument of music, in the best way by harmonizing inner intentions and desires with external demand.

Afferent Pathways↗
PubMed1999

Detection of anterior horn lesions by MRI in central European tick-borne encephalomyelitis.

We report a case of central European tick-borne encephalitis with cervical myelitis presenting clinically as a lower motor neuron syndrome of the upper limbs with proximal asymmetrical pareses and atrophies. There were no sensory deficits nor signs of lesions of the spinal pathways or signs of encephalitis or meningitis. The affected motor fibers of the upper limbs were electrically inexcitable, but sensory findings were normal. Electromyography of the paralyzed muscles revealed pathological denervation activity without voluntary activation. The initial magnetic resonance imaging (MRI) showed a large hyperdense lesion in the anterior part of the cervical cord from C3 to T1. Despite the fact that MRI changes disappeared completely within 6 weeks the patient showed only little improvement in the paralyzed muscles after 6 months. To our knowledge, these MRI changes in patients with tick-borne encephalitis, consistent with an isolated anterior horn lesion, have never been reported previously. The course may have been aggravated by an initial antibiotic treatment with cephalosporins.

Adult↗
PubMed1998

[National Research Program NFP 38: "Diseases of the nervous system"].

The aim of Programme 38 of the Swiss National Research Foundation is to enhance collaboration between basic science and clinical application, as related to diseases of the nervous system, over a 5-year period. The 15 ongoing projects are described. They are mainly concerned with mechanisms of pathogenesis and recovery of function, and ways of modifying them therapeutically after traumatic lesions or various diseases of the nervous system such as stroke, Parkinson's disease, Alzheimer's dementia, depression, meningitis, HMSN etc.

Animals↗