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Biomedical subjects

J Kindler

Publications and source records attributed to J Kindler.

54 records · Page 3Linked to original sources
PubMed1981

[Results of renal transplantation 1968-1979 (author's transl)].

173 renal transplantations were done over a period of 12 years. Among these were 162 first, 10 second and one third transplantation. The one year survival rate of transplanted kidneys (all cases) was around 50%, patient survival was 81.6%. Survival rates did not depend statistically on tissue compatibility, immediate function of kidney, duration of kidney conservation, donor age, commencement of graft versus host reaction, and duration of preoperative dialysis. Although the number of HLA identity has increased during the observation period, there was no increase of transplant survival rate. This may possibly be explained by the negative influence of the steady increase of conservation time during the same period.

Adolescent↗
PubMed1979

Kinetics of elimination of thiocyanate in 7 healthy subjects and in 8 subjects with renal failure.

The concentration of thiocyanate in the serum of eight test subjects with renal failure and seven healthy control subjects was measured, as it declined with time, after oral doses of thiocyanate or i.v. injections of nitroprusside had been administered. Additional measurements were taken, on the healthy subjects only, of the concentrations of thiocyanate in the urine, and also of the influence of an increased chloride intake on the rate of elimination of thiocyanate. For the healthy subjects an elimination half-life of between one and five days (mean c. 3 days) was found. Increasing the chloride elimination rate to approximately twice normal did not significantly speed up the rate of thiocyanate elimination. The amounts of thiocyanate which had been administered as doses reappeared almost exclusively in the urine. For the subjects with renal failure, the elimination half-life had a mean value of approximately nine days. The elimination constants were found to be proportional to the creatinine-clearance rates. The ke value at a creatinine-clearance of zero ml/min was approximately 15% of the ke value at a creatinine-clearance rate of 120 ml/min. The distribution volumes for thiocyanate were greater for the patients with renal failure than for the healthy subjects. The conclusions for therapies using nitroprusside are discussed.

Adult↗
PubMedDate not supplied

Electron microscopic autoradiographic localization of carbocromene in the coronary vessel walls and myocardium.

The ultrastructural distribution of 14-C- and the 3-H-carbocromene in monkeys and rats showed a characteristic pattern in the coronary artery wall and the heart muscle. The radioactivity was found to be located on the coronary vessel wall mainly in the tunica media over the smooth muscle cells and in the myocardium over the contractile elements and the mitochondria.

Administration, Oral↗
PubMedDate not supplied

[Acute renal failure in the aged].

Changes due to ageing appear increasingly during the last third of the lifespan, and the overall performance capability of the organism gradually declines. Loss of function of the kidney, a vital organ, in the form of acute renal failure represents a special hazard to older patients despite modern therapies including the use of the various forms of artificial kidney. In diagnosis, care must be taken to differentiate between functional renal insufficiency and genuine acute renal failure. To prevent the complications arising through acute renal failure, the water, electrolyte and acid/base balances must be extremely carefully monitored and promptly corrected where necessary. The elderly patient with acute renal failure must receive a high calorie intake (approx. 3000 kcal/24h) and must be continuously supplied with adequate quantities of amino acids (at least 1.2--1.5 g/kg-body weight/24h). During treatment should be adjusted to the endogenous creatinine clearance which, in older patients, is often very much lowered at normal serum creatinine. With drugs whose therapeutic range is very narrow, blood-level determinations are needed. To avoid uraemic complications as far as possible, it is advisable to apply, prophylactically, either conventional haemofiltration or continuous arterio-venous haemofiltration at a serum creatinine between 3 and 4 mg/dl and serum urea between 140 and 160 mg/dl. It is of decisive importance that malfunction of other vital functions is prevented, since the mortality for older patients (over 55 years of age) with acute renal failure and no other vital-function disturbance is around 30% but this figure rises to around 75% where acute renal failure and other vital-function disturbances are present.

Acid-Base Imbalance↗